DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atf6 and CREB3L3

DIOPT Version :10

Sequence 1:NP_995745.1 Gene:Atf6 / 35480 FlyBaseID:FBgn0033010 Length:741 Species:Drosophila melanogaster
Sequence 2:NP_115996.1 Gene:CREB3L3 / 84699 HGNCID:18855 Length:461 Species:Homo sapiens


Alignment Length:441 Identity:90/441 - (20%)
Similarity:150/441 - (34%) Gaps:161/441 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 SLDLSELIPDLQK---------EAFGLHFSS-----NPITSEFSLSSPISGLKQIPSACSGEFKR 92
            |.:|.:|:.|.|.         |.:| |...     ||.:.:| |||.:.....:||  |..:..
Human    22 SFELLDLLFDRQDGILRHVELGEGWG-HVKDQQVLPNPDSDDF-LSSILGSGDSLPS--SPLWSP 82

  Fly    93 NVNDNNFQLDLTNSRNDLPEPNSSPTRSLNRSNVNGCSNEEAVYPLLVDSDKFDPFFEPAKVRSP 157
            ..:|:....||.:...|.| |.|.|..|     ..||                    .||:    
Human    83 EGSDSGISEDLPSDPQDTP-PRSGPATS-----PAGC--------------------HPAQ---- 117

  Fly   158 NKEFNSTISNLSDIKNELPETSQDLGFNSYNTSRNNSTLTKSWPINTELNLDNQVPKTVLPLSRT 222
                              |.....|   ||:...:.||.|....|        |||:..:.:...
Human   118 ------------------PGKGPCL---SYHPGNSCSTTTPGPVI--------QVPEASVTIDLE 153

  Fly   223 IYLPS--------HDYKGLLPTVKCN------------GD---------RTLKKNVN-----VRS 253
            ::.|.        .|...|.|  :||            ||         ..|:....     |.:
Human   154 MWSPGGRICAEKPADPVDLSP--RCNLTVKDLLLSGSSGDLQQHHLGASYLLRPGAGHCQELVLT 216

  Fly   254 KISNIVIKKKNATFIQSLKESTPSHTMDDKIYKKYQRMIKNRESASLSRKKRKEYVVSLETRIN- 317
            :....::.|:..|    |....|....::::.||.:|.|:|::||..||||:|||:..||||:: 
Human   217 EDEKKLLAKEGIT----LPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMSA 277

  Fly   318 ------KLEKECDSLKAENITLRDQIFLLATSCQRESGNANGLLHNYSGSERSENKNGRFTSKAK 376
                  :|:::...|:.:|::|.:|:..|.....:.:                            
Human   278 CTAQNQELQRKVLHLEKQNLSLLEQLKKLQAIVVQST---------------------------- 314

  Fly   377 HCNKNNTTATIKKNVAILFAMAFVVSLNAGNFQKYLNIPNNLEGKSEIEPV 427
              :|:..|.|....:.:.||:..:.|::...       ||..|...:..||
Human   315 --SKSAQTGTCVAVLLLSFALIILPSISPFG-------PNKTESPGDFAPV 356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atf6NP_995745.1 bZIP_ATF6 287..338 CDD:269848 22/57 (39%)
coiled coil 287..338 CDD:269848 22/57 (39%)
CREB3L3NP_115996.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..120 23/119 (19%)
bZIP_CREB3 244..304 CDD:269837 23/59 (39%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 245..274 16/28 (57%)
coiled coil 246..297 CDD:269837 19/50 (38%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 285..306 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 370..408
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 442..461
Blue background indicates that the domain is not in the aligned region.

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