DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atf6 and creb3l4

DIOPT Version :9

Sequence 1:	NP_995745.1	Gene:	Atf6 / 35480	FlyBaseID:	FBgn0033010	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001072707.2	Gene:	creb3l4 / 780164	XenbaseID:	XB-GENE-5761389	Length:	435	Species:	Xenopus tropicalis

Alignment Length:	495	Identity:	95/495 - (19%)
Similarity:	171/495 - (34%)	Gaps:	141/495 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DILNSSAFYNDTSLDLSELIPDLQKEAF---GLHFSSNPITSEFSLSSPISGLKQIPSACSGEFK 91
            |:|..|.|.....|..||..|......|   .|.|.:..:..::.:..|: ||.:
Frog     7 DMLLGSLFEQTEELFHSEGFPGPDHSNFPLSELQFPAEKLYEDWPVRGPM-GLSE---------- 60

  Fly    92 RNVNDNNFQLDLTNSRNDLPEPNSSPTRSLNRSNVNGCSNEEAVY---PLLVDSDKFDPFF--EP 151
            |...|...|:.:                           |...||   |...:|.:.|..|  :|
Frog    61 REDTDEFLQMMI---------------------------NPNEVYSTGPAAAESPESDSGFSDDP 98

  Fly   152 AKVRSPNKEFNSTISNLSDIKNELPETSQDLGFNSYNTSRNNST------LTKSWPINTELNLDN 210
            .....|..|.:..:...:.:.    |...|:|......|:::.:      |.:.|.....|..::
Frog    99 RPDTPPQSETSPPLPQPTPVY----ELVYDIGSLEERKSQSDMSSVISIQLAEDWNSAPLLIPES 159

  Fly   211 QVPKTVLPLSRTIYLPSHDYKGLLPTVKCNGDRTLKKNVNVRSKISNIVIKKKNATFIQSLKEST 275
            .:...:.|:.::..||..    |.|......| .|...:::..:...::.::..|     |..:.
Frog   160 CIVNDLPPVCKSTPLPIR----LTPADLIAVD-ALYPELHLTEEEKRLLSQEGVA-----LPNNL 214

  Fly   276 PSHTMDDKIYKKYQRMIKNRESASLSRKKRKEYVVSLETRI-------NKLEKECDSLKAENITL 333
            |....:::|.||.:|.|:|::||..||:::|||:..||:|:       .:|.|:...|:..||:|
Frog   215 PLTKAEERILKKVRRKIRNKQSAQDSRRRKKEYIDGLESRVAACSSQNQELHKKVVELEKHNISL 279

  Fly   334 RDQIFLLATSCQRESGNANG---------------LLHNYSGSERSENKNGRFTSK--AKHCNKN 381
            ..|:..|.|..::.|..|..               :..:||          .|.|:  |...:..
Frog   280 ITQLRKLQTLIKQTSNKAAQTSTCVLILLFSLALLVFPSYS----------PFRSRPSASQEDSY 334

  Fly   382 NTTATIKKNVAILFAMAFVVSLNAGNFQKYLN----------------------IPNNLEGKSEI 424
            ..|..|.:|:           ||.|.|.:..:                      :|.......|.
Frog   335 RPTGVISRNI-----------LNKGGFSEVADPQASDTLHRAQQREEGDPGRHVVPPANPNPEET 388

  Fly   425 EPVGKQLSMSNRRLLWADSEEEYKEKNNLSTFLSGKQKEP 464
            |||      |||.....:.:|:...:...:  :.|::.||
Frog   389 EPV------SNRARTTPEPDEQVLAEPEAA--ILGQKGEP 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atf6	NP_995745.1	bZIP_ATF6	287..338	CDD:269848	21/57 (37%)
Atf6	NP_995745.1	coiled coil	287..338	CDD:269848	21/57 (37%)
creb3l4	NP_001072707.2	bZIP_CREB3	224..284	CDD:269837	22/59 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910