DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atf6 and CREB3L2

DIOPT Version :9

Sequence 1:NP_995745.1 Gene:Atf6 / 35480 FlyBaseID:FBgn0033010 Length:741 Species:Drosophila melanogaster
Sequence 2:NP_919047.2 Gene:CREB3L2 / 64764 HGNCID:23720 Length:520 Species:Homo sapiens


Alignment Length:650 Identity:131/650 - (20%)
Similarity:211/650 - (32%) Gaps:240/650 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 SELIPDLQKEAFGLHFSSNPITSEFSLS-----SPIS-----------GLKQIPSACSGEFKRNV 94
            |||:.:..:...| ...::|..||.|:|     ||.|           .|.:.|.|.| .|....
Human    37 SELLDEFSQNVLG-QLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQS-PFTHIT 99

  Fly    95 NDNNFQLDLTNSR------------------NDLPEPNSSPTRSLNRSNVNGCSNEEAVYPLLVD 141
            ..::|..|...|.                  .|.|.|...|:.:|..:.::              
Human   100 TSDSFNDDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAIS-------------- 150

  Fly   142 SDKFDPFFEPAKVRSPNKEFNSTISN-----LSDIKNELPETSQDLGFNSYNT------------ 189
                    .|.:...|..|.|:.:.:     :..||.|..|..|.|.|:....            
Human   151 --------TPLEKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPP 207

  Fly   190 SRNNSTLTKSWPINTELNLDNQVPKTVLPLSRTIYLPSHDYKGLLPTV--KCNGDRTLKKNVNVR 252
            |.:.|....|...|..|: ...:|:|..|.......||......|.|.  |..|...|       
Human   208 SSHGSDSEGSLSPNPRLH-PFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPL------- 264

  Fly   253 SKISNIVIKKKNATFIQS---LKESTPSHTMDDKIYKKYQRMIKNRESASLSRKKRKEYVVSLET 314
                 ::.:::..|.|..   :....|....::|..||.:|.|||:.||..||:|:|||      
Human   265 -----VLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEY------ 318

  Fly   315 RINKLEKECDSLKAENITLRDQIFLLATSCQRESGNANGLLHNYSGSERSENKNGRFTSK----- 374
             ::.|||:.:|...||:.||.::.:|                        ||.|.....:     
Human   319 -MDSLEKKVESCSTENLELRKKVEVL------------------------ENTNRTLLQQLQKLQ 358

  Fly   375 -------AKHCNKNNT-TATIKKNVAILFAMAFVVSLNAGNFQKYLNIPNNLEGKSEIEPVGKQL 431
                   ::.|....| |.|....|.:.||:||     ...||.|...|:           ..::
Human   359 TLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAF-----GSFFQGYGPYPS-----------ATKM 407

  Fly   432 SMSNRRLLWADSEEEYKEKNNLSTFLSGKQKEPSLYFLNSGIRNHKINSFENITKNVSHTYSYNE 496
            ::.::..|                      :||   :..|.:|:..:..:|.           :.
Human   408 ALPSQHSL----------------------QEP---YTASVVRSRNLLIYEE-----------HS 436

  Fly   497 PPPLTYLSTRNCINRCRSHNGSSNQSKYFMLAQNLHKWISGT--LNVSNFSKEKEDSNGFEFFNN 559
            ||..:            |..||:.:         |..|..|:  |.||.                
Human   437 PPEES------------SSPGSAGE---------LGGWDRGSSLLRVSG---------------- 464

  Fly   560 YFEEKRDIHIKHEKRKMFIDLNDYT---SVLPEKQQKLNNTKSFENMREQINVISKIERRDDTFY 621
             .|.:.|:.:.|     ||..|:.:   |||.|.||.|.:.|...|  |.:.|: :::||.:|.:
Human   465 -LESRPDVDLPH-----FIISNETSLEKSVLLELQQHLVSAKLEGN--ETLKVV-ELDRRVNTTF 520

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atf6NP_995745.1 bZIP_ATF6 287..338 CDD:269848 21/50 (42%)
coiled coil 287..338 CDD:269848 21/50 (42%)
CREB3L2NP_919047.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 195..264 14/69 (20%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 296..325 16/35 (46%)
bZIP_CREB3 305..348 CDD:269837 19/73 (26%)
coiled coil 305..348 CDD:269837 19/73 (26%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 336..357 6/44 (14%)
S1P recognition. /evidence=ECO:0000303|PubMed:17178827 427..430 0/2 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144427
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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