Protein Alignment Atf6 and CREB3L2

DIOPT Version :10

• Sequence 1: NP_995745.1
• Gene: Atf6 / 35480
• FlyBaseID: FBgn0033010
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_919047.2
• Gene: CREB3L2 / 64764
• HGNCID: 23720
• Length: 520
• Species: Homo sapiens
• Alignment Length: 650
• Identity: 131/650 - (20%)
• Similarity: 211/650 - (32%)
• Gaps: 240/650 - (36%)

  Fly    46 SELIPDLQKEAFGLHFSSNPITSEFSLS-----SPIS-----------GLKQIPSACSGEFKRNV 94
            |||:.:..:...| ...::|..||.|:|     ||.|           .|.:.|.|.| .|....
Human    37 SELLDEFSQNVLG-QLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQS-PFTHIT 99

  Fly    95 NDNNFQLDLTNSR------------------NDLPEPNSSPTRSLNRSNVNGCSNEEAVYPLLVD 141
            ..::|..|...|.                  .|.|.|...|:.:|..:.::
Human   100 TSDSFNDDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAIS-------------- 150

  Fly   142 SDKFDPFFEPAKVRSPNKEFNSTISN-----LSDIKNELPETSQDLGFNSYNT------------ 189
                    .|.:...|..|.|:.:.:     :..||.|..|..|.|.|:....
Human   151 --------TPLEKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPP 207

  Fly   190 SRNNSTLTKSWPINTELNLDNQVPKTVLPLSRTIYLPSHDYKGLLPTV--KCNGDRTLKKNVNVR 252
            |.:.|....|...|..|: ...:|:|..|.......||......|.|.  |..|...|
Human   208 SSHGSDSEGSLSPNPRLH-PFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPL------- 264

  Fly   253 SKISNIVIKKKNATFIQS---LKESTPSHTMDDKIYKKYQRMIKNRESASLSRKKRKEYVVSLET 314
                 ::.:::..|.|..   :....|....::|..||.:|.|||:.||..||:|:|||
Human   265 -----VLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEY------ 318

  Fly   315 RINKLEKECDSLKAENITLRDQIFLLATSCQRESGNANGLLHNYSGSERSENKNGRFTSK----- 374
             ::.|||:.:|...||:.||.::.:|                        ||.|.....:
Human   319 -MDSLEKKVESCSTENLELRKKVEVL------------------------ENTNRTLLQQLQKLQ 358

  Fly   375 -------AKHCNKNNT-TATIKKNVAILFAMAFVVSLNAGNFQKYLNIPNNLEGKSEIEPVGKQL 431
                   ::.|....| |.|....|.:.||:||     ...||.|...|:           ..::
Human   359 TLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAF-----GSFFQGYGPYPS-----------ATKM 407

  Fly   432 SMSNRRLLWADSEEEYKEKNNLSTFLSGKQKEPSLYFLNSGIRNHKINSFENITKNVSHTYSYNE 496
            ::.::..|                      :||   :..|.:|:..:..:|.           :.
Human   408 ALPSQHSL----------------------QEP---YTASVVRSRNLLIYEE-----------HS 436

  Fly   497 PPPLTYLSTRNCINRCRSHNGSSNQSKYFMLAQNLHKWISGT--LNVSNFSKEKEDSNGFEFFNN 559
            ||..:            |..||:.:         |..|..|:  |.||.
Human   437 PPEES------------SSPGSAGE---------LGGWDRGSSLLRVSG---------------- 464

  Fly   560 YFEEKRDIHIKHEKRKMFIDLNDYT---SVLPEKQQKLNNTKSFENMREQINVISKIERRDDTFY 621
             .|.:.|:.:.|     ||..|:.:   |||.|.||.|.:.|...|  |.:.|: :::||.:|.:
Human   465 -LESRPDVDLPH-----FIISNETSLEKSVLLELQQHLVSAKLEGN--ETLKVV-ELDRRVNTTF 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atf6	NP_995745.1	bZIP_ATF6	287..338	CDD:269848	21/50 (42%)
		coiled coil	287..338	CDD:269848	21/50 (42%)
CREB3L2	NP_919047.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	195..264		14/69 (20%)
		Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	296..325		16/35 (46%)
		bZIP_CREB3	305..348	CDD:269837	19/73 (26%)
		coiled coil	305..348	CDD:269837	19/73 (26%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	336..357		6/44 (14%)
		S1P recognition. /evidence=ECO:0000303|PubMed:17178827	427..430		0/2 (0%)