DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atf6 and atf6

DIOPT Version :9

Sequence 1:	NP_995745.1	Gene:	Atf6 / 35480	FlyBaseID:	FBgn0033010	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001103989.1	Gene:	atf6 / 558071	ZFINID:	ZDB-GENE-041014-328	Length:	653	Species:	Danio rerio

Alignment Length:	782	Identity:	191/782 - (24%)
Similarity:	297/782 - (37%)	Gaps:	224/782 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EYNLYNDLSLLGEVTENNYDNNIVHDILNSSAFYNDTSLDLSELIPDLQKEAFGLHFSSNPITSE 69
            :.:|:::|..||:..|      ::..::.|..:  |||      :|||.   ||        |.:
Zfish    31 DISLFDELEDLGDADE------LLEALVKSVGY--DTS------VPDLN---FG--------TEQ 70

  Fly    70 FSLSSPISGLKQIPSACSGEFKRNVNDNNFQLDLTNSRNDLPEPNSSPTRSLNRSNVNGCSNEEA 134
            .:.||  .|.::..|..|        |.:..:| :.|.|......|||.....:|..:  :::||
Zfish    71 PAWSS--DGWRETSSPRS--------DGDVTVD-SLSPNHTFSSVSSPASVEPQSPYS--THDEA 122

  Fly   135 V---------YPLLVDSDKFDPFFEPAKVRSPNKEFNSTISN-LSDIKNEL---PETSQDLG--F 184
            :         .||.|.||. ..|.|....:.|:|..|.|.:. |...|..:   |:.|....  .
Zfish   123 LSPDSWRSHPSPLSVCSDS-SGFTEAPNEKKPSKRTNQTKAKPLQPAKRPIQVCPKVSIQPKPII 186

  Fly   185 NSYNTSRNNSTLTKSWPINTELNLDNQVPKTVLPL--------------SRTIYLPSHDYKGLLP 235
            .:...||      .:.|:.|:: :...:..||||:              .:.:.||.......|.
Zfish   187 TAVPISR------PAAPLQTKI-IIQPLQATVLPVVKPPPVTIQPAPPTGQLMQLPQPTQVLQLQ 244

  Fly   236 TVKCNGDRTLKKNVNVRSK-ISNIVIKKKNATFIQSLKESTPSHTMDDKIYKKYQRMIKNRESAS 299
            |.:....|.:......:.: ||.:.....:.....:|:.|||..  |....::.|||||||||||
Zfish   245 TPQSMPTRVVTMPALAQDRPISLVAPVTTSPVVTMTLQNSTPDD--DSNASRRQQRMIKNRESAS 307

  Fly   300 LSRKKRKEYVVSLETRINKLEKECDSLKAENITLRDQIFLLATSCQRESGNANGLLHNYSGSERS 364
            |||||:|||:::||||:.....|.:.||.||.||:.|:              .||:     ||.|
Zfish   308 LSRKKKKEYLMTLETRLKLALTENEKLKNENGTLKRQV--------------EGLM-----SENS 353

  Fly   365 ENKNGRFTSKAKHCNKNNTTATIKKNVAILFAMAFVVSLNAGNFQKYLNIPNNLEGKSEIEPVGK 429
            ..|               .||..::.|.::..:.|:| :|.|        |.:|.|.........
Zfish   354 VLK---------------ATAPKRRAVCLMVVLVFLV-VNLG--------PMSLLGGDRGSAFPA 394

  Fly   430 QLSMSNRRLLWADSEEEYKEKNNLSTFLSGKQKEPSLYFLNSGIRNHKINSFENITKNVSHTYS- 493
            ....:.|.||....|   .|:|     |...|.:||             |:.:.:.:.||...:
Zfish   395 TPVFNGRHLLGFSPE---SERN-----LDKPQTDPS-------------NTVDRLEEGVSEQKAL 438

  Fly   494 --------YNEPPPLTYLSTRNCINRCRSHNGSSNQSKYFMLAQNLHKWISGTLNVSNFSKEKED 550
                    :..|||            |:.   ..|::|...:|..|..|:        ...|.|.
Zfish   439 MVVKDPLYFRTPPP------------CQP---PVNRTKCIKIAHELRGWV--------HRHEVER 480

  Fly   551 SNGFEFFNNYFEEKRDIHIKHEKRKMFIDLNDYTSVLPEKQQKLNNTKSFE-NMREQINV----- 609
            :          :.:|..:.:|..| .|:..:...:.:|:...::..|.|.| |...::.|
Zfish   481 T----------KTRRMSNTQHRGR-TFMKASSKQADVPQIMSQIQYTDSSEKNPGSELQVYYAPH 534

  Fly   610 ------ISKIERRDDTFYVFSFNMDHALLPALSYNSSYRPKLSLVLPLENPG---INGK--MKMI 663
                  ..::.||.|||||.||..||.||||.::|...|||:|:|||..|..   |..|  ..|:
Zfish   535 RTYNDFFDELNRRGDTFYVISFRRDHLLLPATNHNKGSRPKMSVVLPAMNYNESIIKDKDYEVMM 599

  Fly   664 QVDCEVFNTKDFEVSHHLFPAKLRQNVIPRKPNKLNIKKSSTETPVSKTQRVRNFYKVGSRNQAT 728
            |:||||.:||...:.....|..||.|              .|||        .:||.....|...
Zfish   600 QIDCEVMDTKILHIKSSSIPPILRVN--------------QTET--------SSFYHATPSNNQP 642

  Fly   729 VA 730
            .|
Zfish   643 AA 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atf6	NP_995745.1	bZIP_ATF6	287..338	CDD:269848	31/50 (62%)
Atf6	NP_995745.1	coiled coil	287..338	CDD:269848	31/50 (62%)
atf6	NP_001103989.1	bZIP_ATF6	295..346	CDD:269848	31/64 (48%)
atf6	NP_001103989.1	coiled coil	295..346	CDD:269848	31/64 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577530
Domainoid	1	1.000	62	1.000	Domainoid score	I10330
eggNOG	1	0.900	-	-		E1_KOG4343
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	107	1.000	Inparanoid score	I4901
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003511
OrthoInspector	1	1.000	-	-		otm26265
orthoMCL	1	0.900	-	-		OOG6_106428
Panther	1	1.100	-	-	O	PTHR46164
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3813
SonicParanoid	1	1.000	-	-		X2883
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.780