DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atf6 and Atf6b

DIOPT Version :9

Sequence 1:	NP_995745.1	Gene:	Atf6 / 35480	FlyBaseID:	FBgn0033010	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	XP_006256045.1	Gene:	Atf6b / 406169	RGDID:	1303317	Length:	741	Species:	Rattus norvegicus

Alignment Length:	838	Identity:	176/838 - (21%)
Similarity:	278/838 - (33%)	Gaps:	324/838 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DLSLLGEV-------TEN-----NYDNNIVHDI-------------LNSSAFYNDTSLDLS---- 46
            :|.||.|:       |:|     ::|:.:...:             :.....::.:|||:.
  Rat    49 ELMLLSEIADPTRFFTDNLLSPEDWDSTLYSGLDEVAEEQTQLFRCVEQDVPFDSSSLDVGMDVI 113

  Fly    47 ---------ELIPDLQKEAFGLHFSSNPITSEFSLSSPISGLKQIPSACSGEFKRNVNDNNFQLD 102
                     .:.||||.::    ..|:|.:|. ||||..|.|.
  Rat   114 PPEPPWDPLPIFPDLQVKS----EPSSPCSSS-SLSSESSHLS---------------------- 151

  Fly   103 LTNSRNDLPEPNSSPTRSLNRSNVNGCSNEEAVYPL-LVDSDKFDPF------------------ 148
                    .||:|...|.   ..|.....|....|| |:..|...||
  Rat   152 --------TEPSSQVPRV---GEVLQVKMESLAPPLCLLGDDPAFPFETVQITVGSASDDLADIQ 205

  Fly   149 --FEPAKVRSPNKEFNSTISNLS--------------DIKNELPE---------TSQDLGFNSYN 188
              .|||   ||:...||..|.||              ::|.|.|.         .:..||  :..
  Rat   206 TKLEPA---SPSSSVNSEASLLSADSPSQALIGEEVLEVKTESPSPPGCLLWDVPASSLG--AVQ 265

  Fly   189 TSRNNSTLTKSWPINTELNLDNQVPKTVL-----------PLSRTIYL-PSHDYKGLLPTVKCNG 241
            .|...:...:..|:.         ||.|:           |.|..:.| |......:.|.|...|
  Rat   266 ISMGKAPAPRKPPLQ---------PKPVVLTTVPVPPRAGPASTAVLLQPLVQQPAVSPVVLIQG 321

  Fly   242 -------------DRTLKKNVNVRSKISNIVIKKKNATFIQSLKESTPSHT----MDDKIYKKYQ 289
                         .|..:|::                     :....|.:.    :|.|:.|:.|
  Rat   322 AIRAQPEGPAPAAPRPERKSI---------------------VPAPMPGNACPPEVDAKLLKRQQ 365

  Fly   290 RMIKNRESASLSRKKRKEYVVSLETRINKLEKECDSLKAENITLRDQI-FLLATSCQRESGNANG 353
            |||||||||..||:|:|||:..||.|:..:..:...|:.||..||.:: .|||.:.:.:.|:.|
  Rat   366 RMIKNRESACQSRRKKKEYLQGLEARLQAVLADNQQLRRENAALRRRLEALLAENSELKLGSGN- 429

  Fly   354 LLHNYSGSERSENKNGRFTSKAKHCNKNNTTATIKKNVAILFAMAFVVSLNAGNFQKYLNIPNNL 418
                                              :|.|.|:..:.|:    |.||
  Rat   430 ----------------------------------RKVVCIMVFLLFI----AFNF---------- 446

  Fly   419 EGKSEI-EPVGKQLSMSNRRLLWADSEEEYKEKNNLSTFLSGKQKEPSLYFLNSGIRNHKINSFE 482
             |...| ||....:|..:|        |..:.:.:|..|     .||.        ..|.|...:
  Rat   447 -GPVSISEPPPAPVSRMSR--------EGPRPQRHLLGF-----SEPG--------PAHGIEPLQ 489

  Fly   483 NITKNVSHTYSYNEPPPLTYLSTRNCI--------------------NRCRSHNGSSNQSKYFML 527
            ...|....    .:|.|....|.||..                    :.||..    |:::...|
  Rat   490 EAAKGPEE----QQPSPAGKPSFRNLTAFPSGAKELLLRDLDQLFLSSDCRHF----NRTESLRL 546

  Fly   528 AQNLHKWIS--------GTLNVSNFSKEKEDSNGFEFFNNYFEEKRDIHIKHEKRKMFIDLNDYT 584
            |..|..|:.        |...:.:.::|::                    |.:.||....:....
  Rat   547 ADELSGWVQRHQRGHQRGRRKIPHRAQERQ--------------------KSQLRKKSPPVKPVP 591

  Fly   585 SVL--PEKQQKLNNTKSFENM-REQINVISKIERRDDTFYVFSFNMDHALLPALSYNSSYRPKLS 646
            :..  |.::..:...:.:.:. |.|...:..|:||:|||||.||..||.||||:|:|.:.|||:|
  Rat   592 TQPPGPPERDPVGQLQLYRHPGRSQPEFLDAIDRREDTFYVVSFRRDHLLLPAISHNKTSRPKMS 656

  Fly   647 LVLPLENPG--INGK------MKMIQVDCEVFNTKDFEVSHHLFPAKLRQNVIPRKPN 696
            ||:|...|.  ::|:      .:|:|::|||.:|:...:.....|..||:...|...|
  Rat   657 LVMPAMAPNETVSGRGPAGDYEEMMQIECEVMDTRVIHIKTSTVPPSLRKQPSPSPGN 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atf6	NP_995745.1	bZIP_ATF6	287..338	CDD:269848	24/51 (47%)
Atf6	NP_995745.1	coiled coil	287..338	CDD:269848	24/51 (47%)
Atf6b	XP_006256045.1	PHA03160	<271..337	CDD:165431	11/74 (15%)
		bZIP_ATF6	363..414	CDD:269848	24/50 (48%)
		coiled coil	363..414	CDD:269848	24/50 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338123
Domainoid	1	1.000	55	1.000	Domainoid score	I10848
eggNOG	1	0.900	-	-		E1_KOG4343
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003511
OrthoInspector	1	1.000	-	-		oto97980
orthoMCL	1	0.900	-	-		OOG6_106428
Panther	1	1.100	-	-	LDO	PTHR46164
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2883
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.700