DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atf6 and Atf6

DIOPT Version :9

Sequence 1:	NP_995745.1	Gene:	Atf6 / 35480	FlyBaseID:	FBgn0033010	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001100666.1	Gene:	Atf6 / 304962	RGDID:	1305471	Length:	656	Species:	Rattus norvegicus

Alignment Length:	737	Identity:	174/737 - (23%)
Similarity:	287/737 - (38%)	Gaps:	179/737 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EVTENNYDN-NIVHDILNSSAFYNDTSLDLSELIPDLQKEAFGLHFSSNPITSEFSLSSPISGLK 80
            |..|||:|: |...|::   .:.:|.....|....|::.|...|    :|.:|..|:|||.|
  Rat    41 ETYENNFDHLNFDLDLM---PWESDIWSPSSHFCSDIKAEPQPL----SPASSSCSVSSPRS--- 95

  Fly    81 QIPSACSGEFKRNVNDNNFQLD-LTNSRNDL--------------PEPNSSPTRSLNRSNVNGCS 130
              ..:||.  .::|.:   :|| |::|::.|              |.....|.........:|.:
  Rat    96 --TDSCSS--TQHVPE---ELDLLSSSQSPLSLYGDSCHSPSSAEPLKEEKPVTGPGNKTEHGLT 153

  Fly   131 NEEAVYPLLVDSDKFDPFFEPAKVRSPNKEFNSTISNLSDIKNELPE----TSQDLGFNSYNTSR 191
            .::.:......|.:..|...||..::|   .|:::...:.|...||.    ..|....:......
  Rat   154 PKKKIQMSSKPSVQPKPLLLPAAPKTP---ANASVPAKTIIIQTLPALMPLAKQQSIISIQPAPT 215

  Fly   192 NNSTLTKSWPINTELNLDNQVPKTVLPLSRTIYLPSHDYKGLLPTVKCNGDRTLKKN--VN-VRS 253
            ...|:..|.|...:|    |.| .|||.::             |.:...|..|...|  || |.:
  Rat   216 KGQTVLLSQPAVVQL----QTP-GVLPSAQ-------------PVLAVTGGATQLPNHVVNVVPA 262

  Fly   254 KISNIVIKKKNATFIQSLKESTPSHTMDDKIYKKYQRMIKNRESASLSRKKRKEYVVSLETRINK 318
            .:.|..:..|.......|:.||.|...|..:.::.||||||||||..||||:|||::.||.|:..
  Rat   263 PVVNSPVNGKLCVTKPVLQSSTRSTGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKA 327

  Fly   319 LEKECDSLKAENITLRDQIFLLATSCQRESGNANGLLHNYSGSERSENKNGRFTSKAKHCNKNNT 383
            ...|.:.||.||.:|:.|:..:.                      |||:..:..|..
  Rat   328 ALSENEQLKKENGSLKRQLDQVV----------------------SENQRLKVPSPK-------- 362

  Fly   384 TATIKKNVAILFAMAFVVSLNAGNFQKYLNIPNNL--EGKSEIEPVGKQLSMSN-RRLLWADSEE 445
                ::.|.::..:||:: ||.|        |.::  :....::|   .:|.:| ||.|...|.:
  Rat   363 ----RRAVCVMIVLAFIM-LNYG--------PMSMLEQDSRRVKP---SVSPANQRRHLLEFSAK 411

  Fly   446 EYKEKNNLSTFLSGKQKEPSLYFLNSGIRNHKINSFENITKNVSHTYSYNEPPPLTYL------- 503
            |.|:.::     ...||       ||...:|.:::.:.:.........|..|||...|
  Rat   412 EVKDTSD-----GDNQK-------NSYRYDHSVSNDKALMVLSEEPLLYIPPPPCQPLINTTESL 464

  Fly   504 ----STRNCINRCRSHNGSSNQSKYFMLAQNLHKWISGTLNVSNFSKEKEDSNGFEFFNNYFEEK 564
                ..|..::|   |.....:|:....:|...:.:.|.|        ::.||
  Rat   465 RLNHELRGWVHR---HEVERTKSRRMTNSQQKTRILQGAL--------EQGSN------------ 506

  Fly   565 RDIHIKHEKRKMFIDLNDYTSVLPEKQQKLN----NTKSFENMREQINVISKIERRDDTFYVFSF 625
                    .:.|.:...:.||:......:|.    :..|::..      ...|.||.|||||.||
  Rat   507 --------SQLMAVQYTETTSISRNSGSELQVYYASPGSYQGF------FDAIRRRGDTFYVVSF 557

  Fly   626 NMDHALLPALSYNSSYRPKLSLVLPLENPG---INGK--MKMIQVDCEVFNTKDFEVSHHLFPAK 685
            ..||.||||.::|.:.|||:|:|||..|..   |||:  ..|:|:||:|.:|:...:.....|..
  Rat   558 RRDHLLLPATTHNKTTRPKMSIVLPAININDNVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPY 622

  Fly   686 LRQNVIPRKPNKLNIKKSSTET 707
            ||.:...:.........::|||
  Rat   623 LRDHQRNQTSTFFGSPPTATET 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atf6	NP_995745.1	bZIP_ATF6	287..338	CDD:269848	27/50 (54%)
Atf6	NP_995745.1	coiled coil	287..338	CDD:269848	27/50 (54%)
Atf6	NP_001100666.1	Transcription activation. /evidence=ECO:0000305	1..137		28/111 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..171		20/104 (19%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	295..326		15/30 (50%)
		bZIP_ATF6	296..347	CDD:269848	24/50 (48%)
		coiled coil	296..347	CDD:269848	24/50 (48%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	335..342		3/6 (50%)
		Interaction with THBS4. /evidence=ECO:0000250\|UniProtKB:P18850	455..575		25/131 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..656		12/23 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338139
Domainoid	1	1.000	55	1.000	Domainoid score	I10848
eggNOG	1	0.900	-	-		E1_KOG4343
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	95	1.000	Inparanoid score	I4959
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003511
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106428
Panther	1	1.100	-	-	O	PTHR46164
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2883
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.750