DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atf6 and Creb3l1

DIOPT Version :9

Sequence 1:	NP_995745.1	Gene:	Atf6 / 35480	FlyBaseID:	FBgn0033010	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_036087.2	Gene:	Creb3l1 / 26427	MGIID:	1347062	Length:	520	Species:	Mus musculus

Alignment Length:	389	Identity:	84/389 - (21%)
Similarity:	145/389 - (37%)	Gaps:	116/389 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LGEVTENNYDNNI------------VHDILNS--SAFYNDTSLD---------LSELIPDLQKE- 55
            ||::.|:::.||.            :.|..|.  |:|::|..||         |....|.:|.|
Mouse    22 LGDLNESDFLNNAHFPEHLDHFVENMEDFSNDLFSSFFDDPVLDEKSALLDMELDSPAPGIQAEH 86

  Fly    56 AFGLHFSSNPITSEFSLSSPISGLKQIPSACSGEFKRNVNDNNFQL-----DLTNSRNDLPEPNS 115
            ::.|...|.|       .||:..:|.      .:..::|....:.|     .:...:...||
Mouse    87 SYSLSGDSAP-------QSPLVPVKM------EDTTQDVEHGAWALGNKLCSIMVKQEQSPE--- 135

  Fly   116 SPTRSLNRSNVNGCSNEEAVYPLLVDSDKFDPFFE-PAKVRSPNKEFNSTISNLSDIKNELPETS 179
            .|...|..|:....:...|..|||    ...|... |...::|.:     ::.|..||.|.||.|
Mouse   136 LPVDPLAASSAMAAAAAMATPPLL----GLSPMPRLPIPHQAPGE-----MTQLPVIKAEPPEMS 191

  Fly   180 QDLGF-------------NSYNTSRNNSTLTKSWPINTELNLDNQVPKTVLPLSRT--------I 223
            |.|..             :|:.:..:.|...:|.|.::          .|.|::|:        :
Mouse   192 QFLKVTPEDLVQMPPTPPSSHGSDSDGSQSPRSLPPSS----------PVRPMARSSTAISTSPL 246

  Fly   224 YLPSHDYKGLLPTVKCNGDRTLKKNVNVRSKISNIVIKKKNATFIQS---LKESTPSHTMDDKIY 285
            ....|..:|....:                    ::.:::..|.|..   :....|....::|..
Mouse   247 LTAPHKLQGTSGPL--------------------LLTEEEKRTLIAEGYPIPTKLPLTKAEEKAL 291

  Fly   286 KKYQRMIKNRESASLSRKKRKEYVVSLETRI-------NKLEKECDSLKAENITLRDQIFLLAT 342
            |:.:|.|||:.||..||:|:||||..||.::       |:|.|:.::|:..|.||..|:..|.|
Mouse   292 KRVRRKIKNKISAQESRRKKKEYVECLEKKVETYTSENNELWKKVETLETANRTLLQQLQKLQT 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atf6	NP_995745.1	bZIP_ATF6	287..338	CDD:269848	23/57 (40%)
Atf6	NP_995745.1	coiled coil	287..338	CDD:269848	23/57 (40%)
Creb3l1	NP_036087.2	Required for transcription activation. /evidence=ECO:0000250\|UniProtKB:Q96BA8	1..60		9/37 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..259		9/68 (13%)
		bZIP_CREB3	291..344	CDD:269837	20/52 (38%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	292..321		16/28 (57%)
		coiled coil	293..344	CDD:269837	19/50 (38%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	332..353		7/20 (35%)
		S2P recognition. /evidence=ECO:0000250\|UniProtKB:Q96BA8	392..395
		S1P recognition. /evidence=ECO:0000250\|UniProtKB:Q96BA8	423..426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834571
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840