DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atf6 and ATF6

DIOPT Version :9

Sequence 1:	NP_995745.1	Gene:	Atf6 / 35480	FlyBaseID:	FBgn0033010	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	XP_011507610.1	Gene:	ATF6 / 22926	HGNCID:	791	Length:	689	Species:	Homo sapiens

Alignment Length:	774	Identity:	180/774 - (23%)
Similarity:	292/774 - (37%)	Gaps:	240/774 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LSLLGEVTENNYDNNIVHDILNSSAFYNDTSLDL----SEL---------IPDLQKEAFGLHFSS 63
            |....|..|||:||             .|..|||    |::         :.|::.|...|
Human    46 LEAANETYENNFDN-------------LDFDLDLMPWESDIWDINNQICTVKDIKAEPQPL---- 93

  Fly    64 NPITSEFSLSSP-----ISGLKQIPSACSGEFKRNVNDNNFQLDLTNSRNDLP------------ 111
            :|.:|.:|:|||     .|..:.:|.               :|||::|....|
Human    94 SPASSSYSVSSPRSVDSYSSTQHVPE---------------ELDLSSSSQMSPLSLYGENSNSLS 143

  Fly   112 --EP--NSSPTRSLNRSNVNGCSNEEAVYPLLVDSDKFDPFFEPAKVRSPNKEFNSTISN----L 168
              ||  ...|.........||.:.::.:......|.:..|...||   :|..:.||::..    :
Human   144 SAEPLKEDKPVTGPRNKTENGLTPKKKIQVNSKPSIQPKPLLLPA---APKTQTNSSVPAKTIII 205

  Fly   169 SDIKNELPETSQDLGFNSYNTSRNNSTLTKSWPINTELNLDNQVPKTVLPLSRTI--------YL 225
            ..:...:|...|....:.........|:..|.|...:|    |.| .|||.::.:        .|
Human   206 QTVPTLMPLAKQQPIISLQPAPTKGQTVLLSQPTVVQL----QAP-GVLPSAQPVLAVAGGVTQL 265

  Fly   226 PSHDYKGLLPTVKCNGDRTLKKNVNVRSKISNIVIKKKNATFIQSLKESTPSHTMDDKIYKKYQR 290
            |:| ...::|....|..      ||.:..::..|        :||...:..|   |..:.::.||
Human   266 PNH-VVNVVPAPSANSP------VNGKLSVTKPV--------LQSTMRNVGS---DIAVLRRQQR 312

  Fly   291 MIKNRESASLSRKKRKEYVVSLETRINKLEKECDSLKAENITLRDQIFLLATSCQRESGNANGLL 355
            ||||||||..||||:|||::.||.|:.....|.:.||.||.||:.|:..:.
Human   313 MIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGTLKRQLDEVV-------------- 363

  Fly   356 HNYSGSERSENKNGRFTSKAKHCNKNNTTATIKKNVAILFAMAFVVSLNAGNFQKYLNIPNNLEG 420
                    |||:..:..|..            ::.|.::..:||:: ||.|..
Human   364 --------SENQRLKVPSPK------------RRVVCVMIVLAFII-LNYGPM------------ 395

  Fly   421 KSEIEPVGKQLSMS-----NRRLLWADSEEEYK-------EKNNLSTFLSG-KQKEPSLYFLNSG 472
             |.:|...::::.|     .||.|...|.:|.:       :||:.|..|.. :.||.:  |::..
Human   396 -SMLEQDSRRMNPSVSPANQRRHLLGFSAKEAQDTSDGIIQKNSYSKLLRNLRYKETN--FVHPC 457

  Fly   473 IR-NHKINSFENITKNVSHTYSYNEPPPLTYLST----------------RNCINRCRSHNGSSN 520
            .| :|.:::.:.:.........|..|||...|..                |:.:.|.:|...::|
Human   458 FRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNN 522

  Fly   521 QSKYFMLAQNLHKWISGTLNVSNFSKEKEDSNGFEFFNNYFEEKRDIHIKHEKRKMFIDLNDYTS 585
            |.|..:|        .|.|        ::.||                    .:.|.:...:.||
Human   523 QQKTRIL--------QGAL--------EQGSN--------------------SQLMAVQYTETTS 551

  Fly   586 VL-----PEKQQKLNNTKSFENMREQINVISKIERRDDTFYVFSFNMDHALLPALSYNSSYRPKL 645
            .:     .|.|....:.:|:::..|      .|.||.|||||.||..||.||||.::|.:.|||:
Human   552 SISRNSGSELQVYYASPRSYQDFFE------AIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKM 610

  Fly   646 SLVLPLENPG---INGK--MKMIQVDCEVFNTKDFEVSHHLFPAKLRQNVIPRKPNKLN 699
            |:|||..|..   |||:  ..|:|:||:|.:|:...:.....|..||.    ::.|:.|
Human   611 SIVLPAININENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRD----QQRNQTN 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atf6	NP_995745.1	bZIP_ATF6	287..338	CDD:269848	28/50 (56%)
Atf6	NP_995745.1	coiled coil	287..338	CDD:269848	28/50 (56%)
ATF6	XP_011507610.1	bZIP_ATF6	309..360	CDD:269848	28/50 (56%)
ATF6	XP_011507610.1	coiled coil	309..360	CDD:269848	28/50 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144429
Domainoid	1	1.000	56	1.000	Domainoid score	I11004
eggNOG	1	0.900	-	-		E1_KOG4343
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I5041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003511
OrthoInspector	1	1.000	-	-		otm41811
orthoMCL	1	0.900	-	-		OOG6_106428
Panther	1	1.100	-	-	O	PTHR46164
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3813
SonicParanoid	1	1.000	-	-		X2883
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.780