DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Atf6 and ATF6B

DIOPT Version :9

Sequence 1:NP_995745.1 Gene:Atf6 / 35480 FlyBaseID:FBgn0033010 Length:741 Species:Drosophila melanogaster
Sequence 2:NP_004372.3 Gene:ATF6B / 1388 HGNCID:2349 Length:703 Species:Homo sapiens


Alignment Length:806 Identity:181/806 - (22%)
Similarity:288/806 - (35%) Gaps:252/806 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 DLSLLGEVTENN--YDNNIVHDI---LNSSAFYN---------------------------DTSL 43
            :|.||.|:.:..  :.:|::...   |.:|..|:                           |..:
Human     3 ELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGM 67

  Fly    44 DLS------ELI---PDLQKEAFGLHFSSNPITSEFSLSSPISGLKQIPSACS---GEFKRNVND 96
            |:|      ||:   ||||.::    ..|:|.:|. ||||..|.|...||:.:   ||.      
Human    68 DVSPSEPPWELLPIFPDLQVKS----EPSSPCSSS-SLSSESSRLSTEPSSEALGVGEV------ 121

  Fly    97 NNFQLDLTNSRNDLPEP----NSSPTRSLNRSNVNGCSNEEAVYPLLVDSDKFDPFFEPAKVRSP 157
                  |......|..|    ...||.|.....:|       |.|...||.......||.   ||
Human   122 ------LHVKTESLAPPLCLLGDDPTSSFETVQIN-------VIPTSDDSSDVQTKIEPV---SP 170

  Fly   158 NKEFNSTISNLS--------------DIKNE-----------LPETSQDLGF------NSYNTSR 191
            ....||..|.||              ::|.|           :|..|  ||.      .|.:.|.
Human   171 CSSVNSEASLLSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPS--LGAVQISMGPSLDGSS 233

  Fly   192 NNSTLTKSWPINTELNLDNQV--PKTVLPLSRTIYLPSHDYKGLL------PTVKCNGDRTLKKN 248
            ..:..|:..|:..:..:...|  |...:|.|.|:.|.|     |:      |.|...|    ...
Human   234 GKALPTRKPPLQPKPVVLTTVPMPSRAVPPSTTVLLQS-----LVQPPPVSPVVLIQG----AIR 289

  Fly   249 VNVRSKISNIVIKKKNATFIQSLKESTPSHTMDDKIYKKYQRMIKNRESASLSRKKRKEYVVSLE 313
            |.......::...::.:.....:..::....:|.|:.|:.||||||||||..||:|:|||:..||
Human   290 VQPEGPAPSLPRPERKSIVPAPMPGNSCPPEVDAKLLKRQQRMIKNRESACQSRRKKKEYLQGLE 354

  Fly   314 TRINKLEKECDSLKAENITLRDQI-FLLATSCQRESGNANGLLHNYSGSERSENKNGRFTSKAKH 377
            .|:..:..:...|:.||..||.:: .|||.:.:.:.|:.|                         
Human   355 ARLQAVLADNQQLRRENAALRRRLEALLAENSELKLGSGN------------------------- 394

  Fly   378 CNKNNTTATIKKNVAILFAMAFVVSLNAGNFQKYLNIPNNLEGKSEI-EPVGKQLS--------M 433
                      :|.|.|:..:.|:    |.||           |...| ||....:|        .
Human   395 ----------RKVVCIMVFLLFI----AFNF-----------GPVSISEPPSAPISPRMNKGEPQ 434

  Fly   434 SNRRLLWADSEEEYKEKNNLSTFLSG-KQKEPS---------LYFLNSGIRNHKINSFENITKNV 488
            ..|.||....:|..:....|.....| |:.:||         |.....|.:...:...:.:    
Human   435 PRRHLLGFSEQEPVQGVEPLQGSSQGPKEPQPSPTDQPSFSNLTAFPGGAKELLLRDLDQL---- 495

  Fly   489 SHTYSYNEPPPLTYLSTRNCINRCRSHNGSSNQSKYFMLAQNLHKWIS----GTLNVSNFSKEKE 549
                         :||     :.||..    |:::...||..|..|:.    |...:...::|::
Human   496 -------------FLS-----SDCRHF----NRTESLRLADELSGWVQRHQRGRRKIPQRAQERQ 538

  Fly   550 DSNGFEFFNNYFEEKRDIHIKHEKRKMFIDLNDYTSVLPEKQQKLNNTKSFENM-REQINVISKI 613
            .|                  :..|:...:.........|.::..:...:.:.:. |.|...:..|
Human   539 KS------------------QPRKKSPPVKAVPIQPPGPPERDSVGQLQLYRHPDRSQPAFLDAI 585

  Fly   614 ERRDDTFYVFSFNMDHALLPALSYNSSYRPKLSLVLPLENPG--INGK------MKMIQVDCEVF 670
            :||:|||||.||..||.||||:|:|.:.|||:|||:|...|.  ::|:      .:|:|::|||.
Human   586 DRREDTFYVVSFRRDHLLLPAISHNKTSRPKMSLVMPAMAPNETLSGRGAPGDYEEMMQIECEVM 650

  Fly   671 NTKDFEVSHHLFPAKLRQNVIPRKPN 696
            :|:...:.....|..||:...|...|
Human   651 DTRVIHIKTSTVPPSLRKQPSPTPGN 676

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atf6NP_995745.1 bZIP_ATF6 287..338 CDD:269848 24/51 (47%)
coiled coil 287..338 CDD:269848 24/51 (47%)
ATF6BNP_004372.3 Transcription activation 2..86 15/82 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 87..114 11/31 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 229..248 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 293..317 0/23 (0%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 327..347 14/19 (74%)
bZIP_ATF6 328..379 CDD:269848 24/50 (48%)
coiled coil 328..379 CDD:269848 24/50 (48%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 350..357 2/6 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 447..479 6/31 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..565 5/61 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 660..703 5/17 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144413
Domainoid 1 1.000 56 1.000 Domainoid score I11004
eggNOG 1 0.900 - - E1_KOG4343
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 97 1.000 Inparanoid score I5041
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003511
OrthoInspector 1 1.000 - - otm41811
orthoMCL 1 0.900 - - OOG6_106428
Panther 1 1.100 - - LDO PTHR46164
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3813
SonicParanoid 1 1.000 - - X2883
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.780

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