Protein Alignment Atf6 and ATF6B

DIOPT Version :10

• Sequence 1: NP_995745.1
• Gene: Atf6 / 35480
• FlyBaseID: FBgn0033010
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_004372.3
• Gene: ATF6B / 1388
• HGNCID: 2349
• Length: 703
• Species: Homo sapiens
• Alignment Length: 806
• Identity: 181/806 - (22%)
• Similarity: 288/806 - (35%)
• Gaps: 252/806 - (31%)

  Fly    11 DLSLLGEVTENN--YDNNIVHDI---LNSSAFYN---------------------------DTSL 43
            :|.||.|:.:..  :.:|::...   |.:|..|:                           |..:
Human     3 ELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGM 67

  Fly    44 DLS------ELI---PDLQKEAFGLHFSSNPITSEFSLSSPISGLKQIPSACS---GEFKRNVND 96
            |:|      ||:   ||||.::    ..|:|.:|. ||||..|.|...||:.:   ||.
Human    68 DVSPSEPPWELLPIFPDLQVKS----EPSSPCSSS-SLSSESSRLSTEPSSEALGVGEV------ 121

  Fly    97 NNFQLDLTNSRNDLPEP----NSSPTRSLNRSNVNGCSNEEAVYPLLVDSDKFDPFFEPAKVRSP 157
                  |......|..|    ...||.|.....:|       |.|...||.......||.   ||
Human   122 ------LHVKTESLAPPLCLLGDDPTSSFETVQIN-------VIPTSDDSSDVQTKIEPV---SP 170

  Fly   158 NKEFNSTISNLS--------------DIKNE-----------LPETSQDLGF------NSYNTSR 191
            ....||..|.||              ::|.|           :|..|  ||.      .|.:.|.
Human   171 CSSVNSEASLLSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPS--LGAVQISMGPSLDGSS 233

  Fly   192 NNSTLTKSWPINTELNLDNQV--PKTVLPLSRTIYLPSHDYKGLL------PTVKCNGDRTLKKN 248
            ..:..|:..|:..:..:...|  |...:|.|.|:.|.|     |:      |.|...|    ...
Human   234 GKALPTRKPPLQPKPVVLTTVPMPSRAVPPSTTVLLQS-----LVQPPPVSPVVLIQG----AIR 289

  Fly   249 VNVRSKISNIVIKKKNATFIQSLKESTPSHTMDDKIYKKYQRMIKNRESASLSRKKRKEYVVSLE 313
            |.......::...::.:.....:..::....:|.|:.|:.||||||||||..||:|:|||:..||
Human   290 VQPEGPAPSLPRPERKSIVPAPMPGNSCPPEVDAKLLKRQQRMIKNRESACQSRRKKKEYLQGLE 354

  Fly   314 TRINKLEKECDSLKAENITLRDQI-FLLATSCQRESGNANGLLHNYSGSERSENKNGRFTSKAKH 377
            .|:..:..:...|:.||..||.:: .|||.:.:.:.|:.|
Human   355 ARLQAVLADNQQLRRENAALRRRLEALLAENSELKLGSGN------------------------- 394

  Fly   378 CNKNNTTATIKKNVAILFAMAFVVSLNAGNFQKYLNIPNNLEGKSEI-EPVGKQLS--------M 433
                      :|.|.|:..:.|:    |.||           |...| ||....:|        .
Human   395 ----------RKVVCIMVFLLFI----AFNF-----------GPVSISEPPSAPISPRMNKGEPQ 434

  Fly   434 SNRRLLWADSEEEYKEKNNLSTFLSG-KQKEPS---------LYFLNSGIRNHKINSFENITKNV 488
            ..|.||....:|..:....|.....| |:.:||         |.....|.:...:...:.:
Human   435 PRRHLLGFSEQEPVQGVEPLQGSSQGPKEPQPSPTDQPSFSNLTAFPGGAKELLLRDLDQL---- 495

  Fly   489 SHTYSYNEPPPLTYLSTRNCINRCRSHNGSSNQSKYFMLAQNLHKWIS----GTLNVSNFSKEKE 549
                         :||     :.||..    |:::...||..|..|:.    |...:...::|::
Human   496 -------------FLS-----SDCRHF----NRTESLRLADELSGWVQRHQRGRRKIPQRAQERQ 538

  Fly   550 DSNGFEFFNNYFEEKRDIHIKHEKRKMFIDLNDYTSVLPEKQQKLNNTKSFENM-REQINVISKI 613
            .|                  :..|:...:.........|.::..:...:.:.:. |.|...:..|
Human   539 KS------------------QPRKKSPPVKAVPIQPPGPPERDSVGQLQLYRHPDRSQPAFLDAI 585

  Fly   614 ERRDDTFYVFSFNMDHALLPALSYNSSYRPKLSLVLPLENPG--INGK------MKMIQVDCEVF 670
            :||:|||||.||..||.||||:|:|.:.|||:|||:|...|.  ::|:      .:|:|::|||.
Human   586 DRREDTFYVVSFRRDHLLLPAISHNKTSRPKMSLVMPAMAPNETLSGRGAPGDYEEMMQIECEVM 650

  Fly   671 NTKDFEVSHHLFPAKLRQNVIPRKPN 696
            :|:...:.....|..||:...|...|
Human   651 DTRVIHIKTSTVPPSLRKQPSPTPGN 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atf6	NP_995745.1	bZIP_ATF6	287..338	CDD:269848	24/51 (47%)
		coiled coil	287..338	CDD:269848	24/51 (47%)
ATF6B	NP_004372.3	Transcription activation	2..86		15/82 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..114		11/31 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	229..248		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..317		0/23 (0%)
		Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	327..347		14/19 (74%)
		bZIP_ATF6	328..379	CDD:269848	24/50 (48%)
		coiled coil	328..379	CDD:269848	24/50 (48%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	350..357		2/6 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	447..479		6/31 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..565		5/61 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	660..703		5/17 (29%)