Protein Alignment Atf6 and Atf6b

DIOPT Version :9

• Sequence 1: NP_995745.1
• Gene: Atf6 / 35480
• FlyBaseID: FBgn0033010
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_059102.2
• Gene: Atf6b / 12915
• MGIID: 105121
• Length: 706
• Species: Mus musculus
• Alignment Length: 819
• Identity: 180/819 - (21%)
• Similarity: 285/819 - (34%)
• Gaps: 306/819 - (37%)

  Fly     8 LYNDLSLLGEVTENNYD--NNIVHDI-LNSSAFYNDTSLDLS---------ELIPDLQKEAFGLH 60
            ||:.|.   ||.|....  ..:..|: .:||:.  |..:|:|         .:.||||.::
Mouse    38 LYSGLD---EVAEEQAQLFRCVEQDVPFDSSSL--DVGMDVSPPEPPWDPLPIFPDLQVKS---- 93

  Fly    61 FSSNPITSEFSLSSPISGLKQIPSACSGEFKRNVNDNNFQLDLTNSRNDLPEPNSSPTRSLNRSN 125
            ..|:|.:|. ||||..|.|...|                                 |::......
Mouse    94 EPSSPCSSS-SLSSESSHLSTEP---------------------------------PSQVPGVGE 124

  Fly   126 VNGCSNEEAVYPL-LVDSDKFDPF--------------------FEPAKVRSPNKEFNSTISNLS 169
            |.....|....|| |:..|...||                    .|||   ||:...:|..|.||
Mouse   125 VLHVKMESLAPPLCLLGDDPASPFETVQITVGSASDDLSDIQTKLEPA---SPSSSVHSEASLLS 186

  Fly   170 --------------DIKNELPE---------TSQDLGF------NSYNTSRNNSTLTKSWPINTE 205
                          ::|.|.|.         .:..||.      .|.::|...:..|:..|:.
Mouse   187 ADSPSQPFIGEEVLEVKTESPSPPGCLLWDVPASSLGAVQISMGPSPDSSSGKAPATRKPPLQ-- 249

  Fly   206 LNLDNQVPKTVL-----------PLSRTIYL-PSHDYKGLLPTVKCNG-------------DRTL 245
                   ||.|:           |.|..:.| |......:.|.|...|             .|..
Mouse   250 -------PKPVVLTTVPVPPRAGPTSAAVLLQPLVQQPAVSPVVLIQGAIRVQPEGPAPAAPRPE 307

  Fly   246 KKNVNVRSKISNIVIKKKNATFIQSLKESTPSHTMDDKIYKKYQRMIKNRESASLSRKKRKEYVV 310
            :|::.......|                |.|.. :|.|:.|:.||||||||||..||:|:|||:.
Mouse   308 RKSIVPAPMPGN----------------SCPPE-VDAKLLKRQQRMIKNRESACQSRRKKKEYLQ 355

  Fly   311 SLETRINKLEKECDSLKAENITLRDQI-FLLATSCQRESGNANGLLHNYSGSERSENKNGRFTSK 374
            .||.|:..:..:...|:.||..||.:: .|||.:...:.|:.|
Mouse   356 GLEARLQAVLADNQQLRRENAALRRRLEALLAENSGLKLGSGN---------------------- 398

  Fly   375 AKHCNKNNTTATIKKNVAILFAMAFVVSLNAGNFQKYLNIPNNLEGKSEIEPVGKQLSMSNRRLL 439
                         :|.|.|:..:.|:    |.||.     |.::   ||..|.    .||.|.
Mouse   399 -------------RKVVCIMVFLLFI----AFNFG-----PVSI---SEPPPA----PMSPRM-- 432

  Fly   440 WADSEEEYKEKNNLSTF----------------LSGKQKEPSLYFLNSGIRNHKINSFENIT--- 485
               |.||.:.:.:|..|                .|..:::||    ::|     ..||.|:|
Mouse   433 ---SREEPRPQRHLLGFSEPGPAHGMEPLREAAQSPGEQQPS----SAG-----RPSFRNLTAFP 485

  Fly   486 --------KNVSHTYSYNEPPPLTYLSTRNCINRCRSHNGSSNQSKYFMLAQNLHKWIS----GT 538
                    :::...:..::               ||..    |:::...||..|..|:.    |.
Mouse   486 GGAKELLLRDLDQLFLSSD---------------CRHF----NRTESLRLADELSGWVQRHQRGR 531

  Fly   539 LNVSNFSKEKEDSNGFEFFNNYFEEKRDIHIKHEKRKMFIDLNDYTSVL--PEKQQKLNNTKSFE 601
            ..:.:.::|::                    |.:.||....:....:..  |.::..:...:.:.
Mouse   532 RKIPHRAQERQ--------------------KSQLRKKSPPVKPVPTQPPGPPERDPVGQLQLYR 576

  Fly   602 NM-REQINVISKIERRDDTFYVFSFNMDHALLPALSYNSSYRPKLSLVLPLENPG--INGK---- 659
            :. |.|...:..|:||:|||||.||..||.||||:|:|.:.|||:|||:|...|.  ::|:
Mouse   577 HPGRSQPEFLDAIDRREDTFYVVSFRRDHLLLPAISHNKTSRPKMSLVMPAMAPNETVSGRGPPG 641

  Fly   660 --MKMIQVDCEVFNTKDFEVSHHLFPAKLRQNVIPRKPN 696
              .:|:|::|||.:|:...:.....|..||:...|...|
Mouse   642 DYEEMMQIECEVMDTRVIHIKTSTVPPSLRKQPSPSPGN 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atf6	NP_995745.1	bZIP_ATF6	287..338	CDD:269848	24/51 (47%)
		coiled coil	287..338	CDD:269848	24/51 (47%)
Atf6b	NP_059102.2	bZIP_ATF6	332..383	CDD:269848	24/50 (48%)
		coiled coil	332..383	CDD:269848	24/50 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834545
Domainoid	1	1.000	55	1.000	Domainoid score	I11074
eggNOG	1	0.900	-	-		E1_KOG4343
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	96	1.000	Inparanoid score	I5031
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003511
OrthoInspector	1	1.000	-	-		otm43864
orthoMCL	1	0.900	-	-		OOG6_106428
Panther	1	1.100	-	-	LDO	PTHR46164
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3813
SonicParanoid	1	1.000	-	-		X2883
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780