Protein Alignment Atf6 and CREB3

DIOPT Version :10

• Sequence 1: NP_995745.1
• Gene: Atf6 / 35480
• FlyBaseID: FBgn0033010
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_006359.3
• Gene: CREB3 / 10488
• HGNCID: 2347
• Length: 371
• Species: Homo sapiens
• Alignment Length: 209
• Identity: 53/209 - (25%)
• Similarity: 96/209 - (45%)
• Gaps: 50/209 - (23%)

  Fly   170 DIKNELPETSQDLGFNSYNTSRNNSTLTKSWPINTELNLDNQVPK---------TVL--PLSRTI 223
            |:...|.|.|.|||     |:.:.:...   |::..|.| ::||.         ::|  |.|..|
Human    11 DLLAFLLEESGDLG-----TAPDEAVRA---PLDWALPL-SEVPSDWEVDDLLCSLLSPPASLNI 66

  Fly   224 Y------LPSHDYKGLLP--TVKCN---------GDRTLKKNVN--VRSKISNIVIKKKNATFIQ 269
            .      |..||:...||  ||..:         |.:...:::.  ...:|:.:|:..:..:.::
Human    67 LSSSNPCLVHHDHTYSLPRETVSMDLESESCRKEGTQMTPQHMEELAEQEIARLVLTDEEKSLLE 131

  Fly   270 S----LKESTPSHTMDDKIYKKYQRMIKNRESASLSRKKRKEYVVSLETRINK-------LEKEC 323
            .    |.|:.|....:::|.|:.:|.|:|:.||..||:|:|.||..||:|:.|       |:.:.
Human   132 KEGLILPETLPLTKTEEQILKRVRRKIRNKRSAQESRRKKKVYVGGLESRVLKYTAQNMELQNKV 196

  Fly   324 DSLKAENITLRDQI 337
            ..|:.:|::|.||:
Human   197 QLLEEQNLSLLDQL 210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atf6	NP_995745.1	bZIP_ATF6	287..338	CDD:269848	21/58 (36%)
		coiled coil	287..338	CDD:269848	21/58 (36%)
CREB3	NP_006359.3	Transcription activation (acidic). /evidence=ECO:0000269|PubMed:10984507	1..92		24/89 (27%)
		LXXLL motif 1	13..17		0/3 (0%)
		LXXLL motif 2	54..58		0/3 (0%)
		HCFC1-binding-motif (HBM)	78..81		1/2 (50%)
		bZIP_CREB3	151..211	CDD:269837	22/60 (37%)
		Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	152..184		15/31 (48%)
		coiled coil	153..204	CDD:269837	17/50 (34%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	192..213		6/19 (32%)