DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gus and spsb4a

DIOPT Version :9

Sequence 1:	NP_001246140.1	Gene:	gus / 35478	FlyBaseID:	FBgn0026238	Length:	279	Species:	Drosophila melanogaster
Sequence 2:	NP_001243571.1	Gene:	spsb4a / 557906	ZFINID:	ZDB-GENE-070911-3	Length:	277	Species:	Danio rerio

Alignment Length:	280	Identity:	196/280 - (70%)
Similarity:	232/280 - (82%)	Gaps:	7/280 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGQKISGGVKTVSRNDSQSTFKPIIPRELQA-DFVKPARIDILLDMPPASRDLQLKHSWNSEDRS 64
            |||||||.:|:|... .:.:|:| :.|||:. ||.||||:|:||||||||.:.||:|:|||:|||
Zfish     1 MGQKISGSIKSVDVR-GEPSFRP-LRRELRGPDFFKPARLDLLLDMPPASYEQQLRHAWNSDDRS 63

  Fly    65 LNIFVKEDDKLTFHRHPVAQSTDCIRGKVGLTKGLHIWEIYWPTRQRGTHAVVGVCTADAPLHSV 129
            ||||:|:||||||||||||||||.|||:||.|:|||:|.|:||.|||||||||||.|.|||||||
Zfish    64 LNIFIKDDDKLTFHRHPVAQSTDGIRGRVGYTRGLHVWRIHWPARQRGTHAVVGVATGDAPLHSV 128

  Fly   130 GYQSLVGSTEQSWGWDLGRNKLYHDSKN---CAGVTYPAILKNDEAFLVPDKFLVALDMDEGTLS 191
            ||.|||||..:|||||||||||||:|||   .:..|||:.|:.:|||::||..:|.|||||||||
Zfish   129 GYTSLVGSDSESWGWDLGRNKLYHNSKNRPASSAPTYPSFLEPEEAFVLPDTLMVVLDMDEGTLS 193

  Fly   192 FIVDQQYLGIAFRGLRGKKLYPIVSAVWGHCEITMRYIGGLDPEPLPLMDLCRRTIRQKIGRTNL 256
            |:||.||||:|||||:||||||||||||||||||||||.|||||||||||||||..|..:||..|
Zfish   194 FMVDGQYLGVAFRGLKGKKLYPIVSAVWGHCEITMRYINGLDPEPLPLMDLCRRAARLALGRERL 258

  Fly   257 EEHIQQLQLPLSMKTYLLYK 276
            :| |:.|.||.|:|.||.|:
Zfish   259 QE-IETLPLPQSLKNYLQYQ 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gus	NP_001246140.1	SPRY_SOCS1-2-4	56..229	CDD:293963	134/175 (77%)
gus	NP_001246140.1	SOCS_SSB1_4	234..276	CDD:239688	25/41 (61%)
spsb4a	NP_001243571.1	SPRY_SOCS1-2-4	55..231	CDD:293963	134/175 (77%)
spsb4a	NP_001243571.1	SOCS_SSB1_4	236..277	CDD:239688	25/41 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595037
Domainoid	1	1.000	210	1.000	Domainoid score	I2765
eggNOG	1	0.900	-	-		E1_KOG3953
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H25315
Inparanoid	1	1.050	406	1.000	Inparanoid score	I1862
OMA	1	1.010	-	-		QHG48774
OrthoDB	1	1.010	-	-		D399707at33208
OrthoFinder	1	1.000	-	-		FOG0002660
OrthoInspector	1	1.000	-	-		otm25627
orthoMCL	1	0.900	-	-		OOG6_106110
Panther	1	1.100	-	-	LDO	PTHR12245
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4840
SonicParanoid	1	1.000	-	-		X1769
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800