DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gus and Spsb1

DIOPT Version :9

Sequence 1:	NP_001246140.1	Gene:	gus / 35478	FlyBaseID:	FBgn0026238	Length:	279	Species:	Drosophila melanogaster
Sequence 2:	NP_001101464.1	Gene:	Spsb1 / 313722	RGDID:	1309319	Length:	273	Species:	Rattus norvegicus

Alignment Length:	277	Identity:	193/277 - (69%)
Similarity:	227/277 - (81%)	Gaps:	5/277 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGQKISGGVKTVSRNDSQSTFKPIIPRELQA-DFVKPARIDILLDMPPASRDLQLKHSWNSEDRS 64
            ||||::||:|||...|  .|::| :.:|||. |:.||.|:|:||||||.|.|:||.||||:.|||
  Rat     1 MGQKVTGGIKTVDMRD--PTYRP-LKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRS 62

  Fly    65 LNIFVKEDDKLTFHRHPVAQSTDCIRGKVGLTKGLHIWEIYWPTRQRGTHAVVGVCTADAPLHSV 129
            ||:||||||||.|||||||||||.||||||.|:|||:|:|.|..|||||||||||.|||||||||
  Rat    63 LNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSV 127

  Fly   130 GYQSLVGSTEQSWGWDLGRNKLYHDSKNCAGVTYPAILKNDEAFLVPDKFLVALDMDEGTLSFIV 194
            ||.:|||:..:|||||||||:||||.||....||||.|:.||.|:|||.||||||||:|||||||
  Rat   128 GYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIV 192

  Fly   195 DQQYLGIAFRGLRGKKLYPIVSAVWGHCEITMRYIGGLDPEPLPLMDLCRRTIRQKIGRTNLEEH 259
            |.||:|:|||||:||||||:||||||||||.|||:.|||||||||||||||::|..:|:..|..
  Rat   193 DGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYVNGLDPEPLPLMDLCRRSVRLALGKERLGA- 256

  Fly   260 IQQLQLPLSMKTYLLYK 276
            |..|.||.|:|.||||:
  Rat   257 IPALPLPASLKAYLLYQ 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gus	NP_001246140.1	SPRY_SOCS1-2-4	56..229	CDD:293963	134/172 (78%)
gus	NP_001246140.1	SOCS_SSB1_4	234..276	CDD:239688	24/41 (59%)
Spsb1	NP_001101464.1	SPRY_SOCS1-2-4	54..227	CDD:293963	134/172 (78%)
Spsb1	NP_001101464.1	SOCS	232..273	CDD:413360	24/41 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353057
Domainoid	1	1.000	211	1.000	Domainoid score	I2703
eggNOG	1	0.900	-	-		E1_KOG3953
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	407	1.000	Inparanoid score	I1829
OMA	1	1.010	-	-		QHG48774
OrthoDB	1	1.010	-	-		D399707at33208
OrthoFinder	1	1.000	-	-		FOG0002660
OrthoInspector	1	1.000	-	-		otm44465
orthoMCL	1	0.900	-	-		OOG6_106110
Panther	1	1.100	-	-	O	PTHR12245
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1769
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770