DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gus and Spsb4

DIOPT Version :9

Sequence 1:	NP_001246140.1	Gene:	gus / 35478	FlyBaseID:	FBgn0026238	Length:	279	Species:	Drosophila melanogaster
Sequence 2:	NP_001100319.1	Gene:	Spsb4 / 300950	RGDID:	1562307	Length:	273	Species:	Rattus norvegicus

Alignment Length:	277	Identity:	188/277 - (67%)
Similarity:	220/277 - (79%)	Gaps:	5/277 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGQKISGGVKTVSRNDSQSTFKPIIPRELQA-DFVKPARIDILLDMPPASRDLQLKHSWNSEDRS 64
            ||||:||.:|:|...  :...:| ..|||:. :..:|||:|.|||||.|...:||:|:||.||||
  Rat     1 MGQKLSGSLKSVEVR--EPALRP-AKRELRGLEPGRPARLDQLLDMPAAGLAVQLRHAWNPEDRS 62

  Fly    65 LNIFVKEDDKLTFHRHPVAQSTDCIRGKVGLTKGLHIWEIYWPTRQRGTHAVVGVCTADAPLHSV 129
            ||:|||:||:|||||||||||||.||||||..:|||.|:|:||.|||||||||||.||.||||||
  Rat    63 LNVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQIHWPARQRGTHAVVGVATARAPLHSV 127

  Fly   130 GYQSLVGSTEQSWGWDLGRNKLYHDSKNCAGVTYPAILKNDEAFLVPDKFLVALDMDEGTLSFIV 194
            ||.:||||..:||||||||::||||.||..||.|||.|..||||.:||..||.||||||||||||
  Rat   128 GYTALVGSDSESWGWDLGRSRLYHDGKNRPGVAYPAFLGPDEAFALPDSLLVVLDMDEGTLSFIV 192

  Fly   195 DQQYLGIAFRGLRGKKLYPIVSAVWGHCEITMRYIGGLDPEPLPLMDLCRRTIRQKIGRTNLEEH 259
            |.||||:|||||:||||||:|||||||||:|||||.|||||||||||||||:||..:||..|.:
  Rat   193 DGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCRRSIRSALGRQRLRD- 256

  Fly   260 IQQLQLPLSMKTYLLYK 276
            |..|.||.|:|.||.|:
  Rat   257 IGSLPLPQSLKNYLQYQ 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gus	NP_001246140.1	SPRY_SOCS1-2-4	56..229	CDD:293963	133/172 (77%)
gus	NP_001246140.1	SOCS_SSB1_4	234..276	CDD:239688	25/41 (61%)
Spsb4	NP_001100319.1	SPRY_SOCS1-2-4	54..227	CDD:293963	133/172 (77%)
Spsb4	NP_001100319.1	SOCS	232..273	CDD:413360	25/41 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353058
Domainoid	1	1.000	211	1.000	Domainoid score	I2703
eggNOG	1	0.900	-	-		E1_KOG3953
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H25315
Inparanoid	1	1.050	407	1.000	Inparanoid score	I1829
OMA	1	1.010	-	-		QHG48774
OrthoDB	1	1.010	-	-		D399707at33208
OrthoFinder	1	1.000	-	-		FOG0002660
OrthoInspector	1	1.000	-	-		otm44465
orthoMCL	1	0.900	-	-		OOG6_106110
Panther	1	1.100	-	-	LDO	PTHR12245
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1769
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770