DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3107 and CYM1

DIOPT Version :9

Sequence 1:	NP_001036470.1	Gene:	CG3107 / 35475	FlyBaseID:	FBgn0033005	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_010718.1	Gene:	CYM1 / 852041	SGDID:	S000002838	Length:	989	Species:	Saccharomyces cerevisiae

Alignment Length:	1004	Identity:	333/1004 - (33%)
Similarity:	523/1004 - (52%)	Gaps:	76/1004 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KYEEGKTYHGFQCERVEHISEFELTSYTFRYERTGTELWHIDRNDSNNVFSINFRTTPFDSTGLP 127
            ||..|..:||::..|:..:.|..||:....:.:||.|..||||:|.||||||.|:|.|.||||:|
Yeast    19 KYPVGGIFHGYEVRRILPVPELRLTAVDLVHSQTGAEHLHIDRDDKNNVFSIAFKTNPPDSTGVP 83

  Fly   128 HILEHLSLCGSQKYPVRDPFFKMLNRSVATFMNAMTGPDYTIYPFSTMNEIDFRNLQHIYLDAVF 192
            |||||.:||||.|||||||||||||:|:|.|||||||||||.:||||.|..||.||:.:|||:..
Yeast    84 HILEHTTLCGSVKYPVRDPFFKMLNKSLANFMNAMTGPDYTFFPFSTTNPQDFANLRGVYLDSTL 148

  Fly   193 RPNLAYFDFLQEGWRLENKDIFDKQSKLVIKGVVYNEMKGAFSENAQVFSQNLLNNIFPDHTYRH 257
            .|.|...||.|||||||:|:|.|.:|.:|.||||||||||..|.....|......:|:|.   .:
Yeast   149 NPLLKQEDFDQEGWRLEHKNITDPESNIVFKGVVYNEMKGQISNANYYFWSKFQQSIYPS---LN 210

  Fly   258 VSGGNPLEIPKLAYNDLVEFHKKYYHPSNARIYSYGLFDASKTLALLDEEYLSDQSWVDNSYSLI 322
            .|||:|::|..|.|.||::||.|.||||||:.::||......||..|:|::        :.|...
Yeast   211 NSGGDPMKITDLRYGDLLDFHHKNYHPSNAKTFTYGNLPLVDTLKQLNEQF--------SGYGKR 267

  Fly   323 RQQERWTQPRLVHISSRLD-----NMGTTIDRQNQIAIALL-MCDA-TNIQESFELHVLSEVLIR 380
            .::::...|  :.:...:|     .:.|.:..:.|...::. :|.| .:..::|.|.||..:|:.
Yeast   268 ARKDKLLMP--IDLKKDIDVKLLGQIDTMLPPEKQTKASMTWICGAPQDTYDTFLLKVLGNLLMD 330

  Fly   381 GPNSPFYKNLIEPNFSGGYNQTTGYSSDTKDTTFVVGLQDLRVEDFKKCIEIFDKTIINSMND-- 443
            |.:|..|:.|||......::..:|....|......||:|.  |.|    ||||..|:.|...:
Yeast   331 GHSSVMYQKLIESGIGLEFSVNSGVEPTTAVNLLTVGIQG--VSD----IEIFKDTVNNIFQNLL 389

  Fly   444 ----GFDSQHVESVLHNLELSLKHQNPNFGNTLLFNSTALWNHDGDVVSNLRVSDMISGLRESI- 503
                .||.:.:::::..||||.|.|..:||..||::....|.:..|...:|...|::...|..:
Yeast   390 ETEHPFDRKRIDAIIEQLELSKKDQKADFGLQLLYSILPGWTNKIDPFESLLFEDVLQRFRGDLE 454

  Fly   504 SQNKKYFQEKIEKYFANNNHR--LTLTMSPDEAYEDKFKQAELELVEQKVKLLDEVKIEKIYERG 566
            ::....||:.|.||..   |:  .|.::...|.:.......|...:.:|:..|||...:.|::||
Yeast   455 TKGDTLFQDLIRKYIV---HKPCFTFSIQGSEEFSKSLDDEEQTRLREKITALDEQDKKNIFKRG 516

  Fly   567 LILDSYQKAESNTDLLPCLTMNDVRDPPKWPKLFIQNVQNVRTQICKVPTNEITYF--KCMFNIT 629
            ::|...|..:.:...||.|.:.|:  |....|..|:...|..::|  ..||.|||.  |.:.|..
Yeast   517 ILLQEKQNEKEDLSCLPTLQIKDI--PRAGDKYSIEQKNNTMSRI--TDTNGITYVRGKRLLNDI 577

  Fly   630 GLSHEETQLMPLFCNVISAMGTTNYNYREFDKHILLKTGGFDFKLHLIEDVRDSKSYSLSVMINT 694
             :..|....:|||...::.:|||..::.|.:..|.|.|||....:.:..|...::. .|....:.
Yeast   578 -IPFELFPYLPLFAESLTNLGTTTESFSEIEDQIKLHTGGISTHVEVTSDPNTTEP-RLIFGFDG 640

  Fly   695 HALNNNVPEMFALCQELIKNVRF-DDSERLKMLIENYISYISVGVASSGHLYAMLGATSQVCDAG 758
            .:||:....:|....:::....| .:|::||:||....|..:..||.:||.:|...:.:....:|
Yeast   641 WSLNSKTDHIFEFWSKILLETDFHKNSDKLKVLIRLLASSNTSSVADAGHAFARGYSAAHYRSSG 705

  Fly   759 KLKSLLYGVDHIDFMKNFVHS------TSTVDICDKLSTIASKVFNKDNMRGAINTTQSYEPSAI 817
            .:...|.|::.:.|: |.:||      |...::.|||:.:...:.:.:||...|.:....:...:
Yeast   706 AINETLNGIEQLQFI-NRLHSLLDNEETFQREVVDKLTELQKYIVDTNNMNFFITSDSDVQAKTV 769

  Fly   818 -SNYEKFLESLP---TFGKTQTSRNIHYLDPSCQQYVMNIP--VNYCAKALFTVPYLHQDHPTLR 876
             |...||:|.||   .......:.:...:...|:..::..|  |:|.::||..|||.|:|...|:
Yeast   770 ESQISKFMERLPHGSCLPNGPKTSDYPLIGSKCKHTLIKFPFQVHYTSQALLGVPYTHKDGSALQ 834

  Fly   877 VLAKLLSAKYLLPVIREKNGAYGAGAKISS-DGIFSFYSYRDPNSTKTLNAFDETYKWL--RANQ 938
            |::.:|:.|:|...:|||.||||.||..|: .|||||||||||...|:|..|..:.:::  .|..
Yeast   835 VMSNMLTFKHLHREVREKGGAYGGGASYSALAGIFSFYSYRDPQPLKSLETFKNSGRYILNDAKW 899

  Fly   939 NVIDQQSLFESKLGVLQQLDTPIAPGNIGIDYFLYEVSQEDFESYRSRMLSVTIDDLQCAIENY- 1002
            .|.|   |.|:||.:.||:|.|.:|...|:.||:..|:.:..::.|.::|.|::.|:....|.|
Yeast   900 GVTD---LDEAKLTIFQQVDAPKSPKGEGVTYFMSGVTDDMKQARREQLLDVSLLDVHRVAEKYL 961

  Fly  1003 FGKESMHYGKCILGP------VNANLELE 1025
            ..||.:   ..::||      |:.|.|::
Yeast   962 LNKEGV---STVIGPGIEGKTVSPNWEVK 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3107	NP_001036470.1	Cym1	68..1003	CDD:223957	323/969 (33%)
		Peptidase_M16	120..>177	CDD:279066	45/56 (80%)
		Peptidase_M16_C	268..457	CDD:282978	52/201 (26%)
		M16C_assoc	531..773	CDD:285556	60/244 (25%)
CYM1	NP_010718.1	Cym1	24..989	CDD:223957	330/999 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345606
Domainoid	1	1.000	103	1.000	Domainoid score	I1504
eggNOG	1	0.900	-	-		E1_COG1026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I213
Isobase	1	0.950	-	0	Normalized mean entropy	S1786
OMA	1	1.010	-	-		QHG63001
OrthoFinder	1	1.000	-	-		FOG0004106
OrthoInspector	1	1.000	-	-		oto99080
orthoMCL	1	0.900	-	-		OOG6_101809
Panther	1	1.100	-	-	LDO	PTHR43016
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R283
SonicParanoid	1	1.000	-	-		X2847
TreeFam	1	0.960	-	-
	15	14.740