DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3107 and PREP2

DIOPT Version :9

Sequence 1:	NP_001036470.1	Gene:	CG3107 / 35475	FlyBaseID:	FBgn0033005	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_175386.2	Gene:	PREP2 / 841387	AraportID:	AT1G49630	Length:	1080	Species:	Arabidopsis thaliana

Alignment Length:	975	Identity:	290/975 - (29%)
Similarity:	481/975 - (49%)	Gaps:	91/975 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 GFQCERVEHISEFELTSYTFRYERTGTELWHIDRNDSNNVFSINFRTTPFDSTGLPHILEHLSLC 136
            ||:....|.|||.:..:..|::::||.|:..:..:|.|.||.|.|||.|.||||:||||||..||
plant   105 GFEKVSEEFISECKSKAVLFKHKKTGCEVMSVSNDDENKVFGIVFRTPPKDSTGIPHILEHSVLC 169

  Fly   137 GSQKYPVRDPFFKMLNRSVATFMNAMTGPDYTIYPFSTMNEIDFRNLQHIYLDAVFRPNLA--YF 199
            ||:|||:::||.::|..|:.||:||.|.||.|.||.::.|:.||.||..:||||||.|...  ..
plant   170 GSRKYPMKEPFVELLKGSLHTFLNAFTYPDRTCYPVASTNKKDFYNLVDVYLDAVFFPKCVDDVH 234

  Fly   200 DFLQEGWRLENKDIFDKQSKLVIKGVVYNEMKGAFSENAQVFSQNLLNNIFPDHTYRHVSGGNPL 264
            .|.||||..|   :.|....:..||||:|||||.:|:...:..:.....:.|::||...|||:|.
plant   235 TFQQEGWHYE---LNDPSEDISYKGVVFNEMKGVYSQPDNILGRVTQQALCPENTYGVDSGGDPK 296

  Fly   265 EIPKLAYNDLVEFHKKYYHPSNARIYSYGLFDASKTLALLDEEYLS--DQSWVDNSYSLIRQQER 327
            :||||.:....|||::|||||||||:.||..|....|.:| .|||.  |.|...:| |.:..|:.
plant   297 DIPKLTFEKFKEFHRQYYHPSNARIWFYGDDDPVHRLRVL-SEYLDMFDASPARDS-SKVEPQKL 359

  Fly   328 WTQPRLVHISSRLDNMGTTIDRQNQIAIALLMCD-ATNIQESFELHVLSEVLIRGPNSPFYKNLI 391
            :::||.: :..........:.:::.:.:..|:.| ..::|....|..|..:::..|.||..|.|:
plant   360 FSRPRRI-VEKYPAGEDGDLKKKHMVCLNWLLSDKPLDLQTQLALGFLDHLMLGTPASPLRKILL 423

  Fly   392 EPNFSGGYNQTTGYSSDTKDTTFVVGLQDLRVEDFKKCIEIFDKTIINSMNDGFDSQHVESVLHN 456
            |... |.....:|...:.....|.:||:.:..::.:|..|:...|:....::|||:..||:.::.
plant   424 ESGL-GEALVNSGMEDELLQPQFSIGLKGVSDDNVQKVEELVMNTLRKLADEGFDTDAVEASMNT 487

  Fly   457 LELSLKHQNPNF---GNTLLFNSTALWNHDGDVVSNLRVSDMISGLRESISQ--NKKYFQEKIEK 516
            :|.||:..|...   |.:|:..|.|.|.:|.|....|:..:.:..|:..|::  :|..|...||:
plant   488 IEFSLRENNTGSSPRGLSLMLQSIAKWIYDMDPFEPLKYEEPLKSLKARIAEKGSKSVFSPLIEE 552

  Fly   517 YFANNNHRLTLTMSPDEAYEDKFKQAELELVEQKVKLLDEVKI----EKIYERGLILDSYQKAES 577
            |..||.|.:|:.|.||.      ::|.||..|:| .:|::||.    |.:.|.....:..:..:.
plant   553 YILNNPHCVTIEMQPDP------EKASLEEAEEK-SILEKVKASMTEEDLTELARATEELRLKQE 610

  Fly   578 NTD------LLPCLTMNDVRDPPKWPKLFIQNVQNVRTQICKVPTNEITYFKCMFNITGLSHEET 636
            ..|      .:|.|.::|:...|.:....:.::..|:.....:.||.|.|.:.:|::..:.||..
plant   611 TPDPPDALKCVPSLNLSDIPKEPIYVPTEVGDINGVKVLRNDLFTNNILYTEVVFDMGSVKHELL 675

  Fly   637 QLMPLFCNVISAMGTTNYNYREFDKHILLKTGGFDFKLHLIEDVRDSKSYSLSVMINTHALNNNV 701
            ||:||||..:..|||.:..:.:.::.|..||||... ..|...|.........:::...::....
plant   676 QLIPLFCQSLLEMGTQDLTFVQLNQLIGRKTGGISV-YPLTSSVYGRDDPCSKIIVRGKSMVGRA 739

  Fly   702 PEMFALCQELIKNVRFDDSERLKMLI-------ENYISYISVGVASSGHLYAMLGATSQVCDAGK 759
            .::|.|...:::.|||.|.:|.|..:       ||.:.....|:|:: .:.|||..      ||.
plant   740 EDLFNLMNCVLQEVRFTDQQRFKQFVSQSRARMENRLRGSGQGIAAA-RMDAMLNV------AGW 797

  Fly   760 LKSLLYGVDHIDFMKNFVHSTSTVD-----ICDKLSTIASKVFNKDNMRGAINTTQSYEPSAISN 819
            :...:.|:.:::|:...   ...||     |...|..|.....:::..  .:|.|.  :..:::|
plant   798 MSEQMGGLSYLEFLHTL---EQKVDQDWEGISSSLEEIRRSFLSRNGC--IVNMTA--DGKSLTN 855

  Fly   820 YE----KFLESLP--------TFGKTQTSRNIHYLDPSCQQYVMNIPVNYCAKA--LFTVPYLHQ 870
            .|    |||:.||        |:......||        :..|:...|||..||  :::..|  :
plant   856 TEKYVGKFLDLLPENPSGELVTWDARLPLRN--------EAIVIPTQVNYVGKAGNIYSSGY--K 910

  Fly   871 DHPTLRVLAKLLSAKYLLPVIREKNGAYGAGAKISS-DGIFSFYSYRDPNSTKTLNAFDETYKWL 934
            ...:..|::|.:|..:|...:|...||||......| .|:|||.||||||..|||:.:|.|..:|
plant   911 LDGSSYVISKHISNTWLWDRVRVSGGAYGGSCDFDSHSGVFSFLSYRDPNLLKTLDIYDGTGDFL 975

  Fly   935 RANQNVIDQQSLFESKLGVLQQLDT---PIAPGNIGIDYFLYEVSQEDFESYRSRMLSVTIDDLQ 996
            |...  :|:.:|.::.:|.:..:|:   |.|.|...:...|..|:.|:.:..|..:||.::.|.:
plant   976 RGLD--VDEDTLTKAIIGTIGDVDSYQLPDAKGYTSLLRHLLNVTDEERQIRREEILSTSLKDFK 1038

Fly 997 996
plant 1039 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3107	NP_001036470.1	Cym1	68..1003	CDD:223957	290/975 (30%)
		Peptidase_M16	120..>177	CDD:279066	32/56 (57%)
		Peptidase_M16_C	268..457	CDD:282978	53/191 (28%)
		M16C_assoc	531..773	CDD:285556	59/258 (23%)
PREP2	NP_175386.2	Cym1	105..1078	CDD:223957	290/975 (30%)
		Peptidase_M16	153..>228	CDD:279066	43/74 (58%)
		Peptidase_M16_C	300..486	CDD:282978	53/189 (28%)
		M16C_assoc	567..811	CDD:285556	59/258 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	77	1.000	Domainoid score	I3100
eggNOG	1	0.900	-	-		E1_COG1026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5742
Inparanoid	1	1.050	391	1.000	Inparanoid score	I498
OMA	1	1.010	-	-		QHG63001
OrthoDB	1	1.010	-	-		D107079at2759
OrthoFinder	1	1.000	-	-		FOG0004106
OrthoInspector	1	1.000	-	-		otm2999
orthoMCL	1	0.900	-	-		OOG6_101809
Panther	1	1.100	-	-	LDO	PTHR43016
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2847
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840