DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3107 and pitrm1

DIOPT Version :9

Sequence 1:	NP_001036470.1	Gene:	CG3107 / 35475	FlyBaseID:	FBgn0033005	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_001039262.1	Gene:	pitrm1 / 734137	XenbaseID:	XB-GENE-952658	Length:	1027	Species:	Xenopus tropicalis

Alignment Length:	1005	Identity:	416/1005 - (41%)
Similarity:	591/1005 - (58%)	Gaps:	38/1005 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 KRKYKYEEGKTYHGFQCERVEHISEFELTSYTFRYERTGTELWHIDRNDSNNVFSINFRTTPFDS 123
            :|..:|..|::.|||....|..:.|..||:....::.||.:..|:.|.||||:||:.|||||.||
Frog    29 ERALRYAPGESIHGFTVNEVTPVPELFLTAVKLSHDNTGAKYLHVAREDSNNLFSVQFRTTPLDS 93

  Fly   124 TGLPHILEHLSLCGSQKYPVRDPFFKMLNRSVATFMNAMTGPDYTIYPFSTMNEIDFRNLQHIYL 188
            ||:||||||..||||||||.|||||||||||::|||||.|..|||:|||||.|..||:||..:||
Frog    94 TGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTMYPFSTQNAKDFQNLLSVYL 158

  Fly   189 DAVFRPNLAYFDFLQEGWRLENKDIFDKQSKLVIKGVVYNEMKGAFSENAQVFSQNLLNNIFPDH 253
            ||||.|.|...||.|||||||:::..|..|.|:.||:|:|||||||::|.:||||:|.|.:.|||
Frog   159 DAVFFPCLRELDFWQEGWRLEHENPEDPNSPLIFKGIVFNEMKGAFTDNEKVFSQHLQNKLLPDH 223

  Fly   254 TYRHVSGGNPLEIPKLAYNDLVEFHKKYYHPSNARIYSYGLFDASKTLALLDEEYLSDQSWVDNS 318
            ||..||||.||.||.|.:..|.:||..:|||||||.::||.......|..:.|:.||....:|..
Frog   224 TYSVVSGGEPLNIPDLTWEQLKQFHATHYHPSNARFFTYGNLPLEIHLKQIHEDALSKFERIDPK 288

  Fly   319 YSLIRQQERWTQPRLVHISSRLDNMGTTIDRQNQIAIALLMCDATNIQESFELHVLSEVLIRGPN 383
            .| :..||||..||...||...|:..:..::|..:::..|:.:.|:..|:|.|.:||.:::.|||
Frog   289 TS-VPPQERWQSPREYSISCGTDSFASDPEKQTTVSVNFLLSEITDTFEAFTLSLLSSLMVDGPN 352

  Fly   384 SPFYKNLIEPNFSGGYNQTTGYSSDTKDTTFVVGLQDLRVEDFKKCIEIFDKTIINSMNDGFDSQ 448
            |||||.|||.|....::..||:::.|::|.|.:|||.:..||.:|...|.:|||......|.:::
Frog   353 SPFYKALIEANLGTDFSPDTGFNNYTRETYFSIGLQGINKEDSEKVKAIINKTINEVAEHGIEAE 417

  Fly   449 HVESVLHNLELSLKHQNPNFGNTLLFNSTALWNHDGDVVSNLRVSDMISGLRESISQNKKYFQEK 513
            .:|::||.||:.:|||:.:||.||.....:.|||:||.|..|::.|.||..||.:.:|.|:.|:|
Frog   418 RIEALLHKLEIQMKHQSTSFGLTLASYVASCWNHEGDPVDLLKIGDKISRFRECLKENPKFLQDK 482

  Fly   514 IEKYFANNNHRLTLTMSPDEAYEDKFKQAELELVEQKVKLLDEVKIEKIYERGLILDSYQKAESN 578
            :::||..:.||:||:|||||.:.||..|.|.|.:.||||.|.|.:.::|||:||.|...|....:
Frog   483 VKQYFQVSQHRMTLSMSPDEQHYDKEAQLEAEKLTQKVKALSEEERKQIYEKGLELIRLQSKPQD 547

  Fly   579 TDLLPCLTMNDVRDPPKWP--KLFIQNVQNVRTQICKVPTNEITYFKCMFNITGLSHEETQLMPL 641
            ...||.|.::|:.  ||.|  .|.|....:|..|.|..|||.:.||:.:.::..|..|....:||
Frog   548 ASCLPALKVSDIE--PKIPLTDLDITYAGDVPVQYCAQPTNGMVYFRAVSSLNTLPEELKPYVPL 610

  Fly   642 FCNVISAMGTTNYNYREFDKHILLKTGGFDFKLHLIEDVRDSKSYSLSVMINTHALNNNVPEMFA 706
            ||:||:.:|...|||||..:.:.|.|||.....|:|.|..:..:|...|:.::..|:.|:|:|..
Frog   611 FCSVITKLGCGVYNYREQAQQMELTTGGMSVCPHIITDDSNLDTYEQGVVFSSLCLDRNLPDMMH 675

  Fly   707 LCQELIKNVRFDDSERLKMLIENYISYISVGVASSGHLYAMLGATSQVCDAGKLKSLLYGVDHID 771
            |..|:..:..|||.|||::|:......:|.|:..|||:||.:.|...:..||:|:.|..|:|.:.
Frog   676 LWSEIFNSPHFDDEERLRVLVRMSAQEMSNGIPDSGHVYASIRAGRTLTPAGELQELFSGMDQVK 740

  Fly   772 FMKNFVHSTSTVDICDKLSTIASKVFNKDNMRGAINTTQSYEPSAISNYEKFLESLPTFGKTQTS 836
            .:|..........|..|||.|...|...||||.::|.|....|.|....|.||..:....|.:.|
Frog   741 MIKRIAEMPEMGPILRKLSRIRKYVLLSDNMRCSVNATPQQMPVASKEIEHFLAGISRSKKERKS 805

  Fly   837 RNIHYLDPS--------------------------CQ---QYVMNIPVNYCAKALFTVPYLHQDH 872
            ...|.::.|                          ||   .:.::.||||..:.:.||||.|.|:
Frog   806 IRPHVVEKSSSPSSSGSEISRRATRKLVGDPTFKPCQMKTHFSLSFPVNYIGECVRTVPYTHPDY 870

  Fly   873 PTLRVLAKLLSAKYLLPVIREKNGAYGAGAKISSDGIFSFYSYRDPNSTKTLNAFDETYKWLRAN 937
            .:||:||::::||:|...||||.||||.|||:|.||||.|||||||||..||:.|.:...|.::.
Frog   871 ASLRILARIMTAKFLHGEIREKGGAYGGGAKLSFDGIFGFYSYRDPNSLSTLSTFQKAADWAKSG 935

  Fly   938 QNVIDQQSLFESKLGVLQQLDTPIAPGNIGIDYFLYEVSQEDFESYRSRMLSVTIDDLQCAIENY 1002
            |  ..||.:.|:||.|...:|:||||.:.|:::||:.:|.|..:.:|.::.:||..||..|...|
Frog   936 Q--FTQQDVDEAKLSVFSAVDSPIAPSDKGMNHFLHGISDEMKQKHREQLFAVTHSDLTNASNKY 998

  Fly  1003 FGKESMHYGKCILGPVNANLELETSHKWII 1032
            ........|..||||.|.|:..:.|  |||
Frog   999 LTAGQCTRGTAILGPENRNIAKDPS--WII 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3107	NP_001036470.1	Cym1	68..1003	CDD:223957	401/965 (42%)
		Peptidase_M16	120..>177	CDD:279066	44/56 (79%)
		Peptidase_M16_C	268..457	CDD:282978	67/188 (36%)
		M16C_assoc	531..773	CDD:285556	88/243 (36%)
pitrm1	NP_001039262.1	Cym1	41..1000	CDD:223957	402/963 (42%)
		Peptidase_M16	90..>171	CDD:279066	57/80 (71%)
		Peptidase_M16_C	238..426	CDD:282978	67/188 (36%)
		M16C_assoc	500..742	CDD:285556	88/243 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	800..829		4/28 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I4043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5742
Inparanoid	1	1.050	779	1.000	Inparanoid score	I521
OMA	1	1.010	-	-		QHG63001
OrthoDB	1	1.010	-	-		D107079at2759
OrthoFinder	1	1.000	-	-		FOG0004106
OrthoInspector	1	1.000	-	-		otm47658
Panther	1	1.100	-	-	LDO	PTHR43016
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R283
SonicParanoid	1	1.000	-	-		X2847
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110