DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3107 and pitrm1

DIOPT Version :9

Sequence 1:	NP_001036470.1	Gene:	CG3107 / 35475	FlyBaseID:	FBgn0033005	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_998652.1	Gene:	pitrm1 / 406808	ZFINID:	ZDB-GENE-040426-2876	Length:	1023	Species:	Danio rerio

Alignment Length:	1002	Identity:	393/1002 - (39%)
Similarity:	588/1002 - (58%)	Gaps:	37/1002 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 KRKYKYEEGKTYHGFQCERVEHISEFELTSYTFRYERTGTELWHIDRNDSNNVFSINFRTTPFDS 123
            ::..||..|:..|.|..:.|..:.:..||:....::.||.:..|..|:||||:||:.|||||.||
Zfish    30 EKALKYTVGQKIHNFTVKEVTAVPDLFLTAVKLSHDATGAQYLHAARDDSNNLFSVLFRTTPMDS 94

  Fly   124 TGLPHILEHLSLCGSQKYPVRDPFFKMLNRSVATFMNAMTGPDYTIYPFSTMNEIDFRNLQHIYL 188
            ||:||||||..|||||::|.|||||||||||::|||||.|..|||:|||||.|..||:||..:||
Zfish    95 TGVPHILEHTVLCGSQRFPCRDPFFKMLNRSLSTFMNAFTASDYTMYPFSTQNAKDFQNLLSVYL 159

  Fly   189 DAVFRPNLAYFDFLQEGWRLENKDIFDKQSKLVIKGVVYNEMKGAFSENAQVFSQNLLNNIFPDH 253
            ||||.|.|...||.|||||||:::..|..|.||.||||:|||||.||:|.::::|:|.|.:.|||
Zfish   160 DAVFFPCLRELDFWQEGWRLEHENPTDPSSPLVFKGVVFNEMKGVFSDNERLYAQHLQNKLLPDH 224

  Fly   254 TYRHVSGGNPLEIPKLAYNDLVEFHKKYYHPSNARIYSYGLFDASKTLALLDEEYLSDQSWVDNS 318
            ||..||||.||.||:|.:..|..||..:|||||||.::||.....:.|..::||.:|.....:.:
Zfish   225 TYSVVSGGEPLAIPELTWEQLKHFHATHYHPSNARFFTYGDLPLEQHLQQIEEEAMSKFERTEPN 289

  Fly   319 YSLIRQQERWTQPRLVHISSRLDNMGTTIDRQNQIAIALLMCDATNIQESFELHVLSEVLIRGPN 383
             :.:..|..|.:||:.|:|.|.|.:.....:||.:.::.|:.|.|:..|.|.|.:||.:::.|||
Zfish   290 -TAVPPQTPWDKPRMDHVSCRPDALAPDPVKQNTLCMSFLLGDITDTFEMFTLSLLSSLMMSGPN 353

  Fly   384 SPFYKNLIEPNFSGGYNQTTGYSSDTKDTTFVVGLQDLRVEDFKKCIEIFDKTIINSMNDGFDSQ 448
            |||||.||||.....::.:.|:...|:..:|.:|||.:..:|.:....|..:||.:.:..||:.:
Zfish   354 SPFYKALIEPKIGSDFSSSAGFDGSTRQASFTIGLQGMAEDDTETVKHIIAQTIDDIIASGFEEE 418

  Fly   449 HVESVLHNLELSLKHQNPNFGNTLLFNSTALWNHDGDVVSNLRVSDMISGLRESISQNKKYFQEK 513
            .:|::||.:|:.:|||:.:||..|.....:|||||||.|..|::|:.:|..|:.:.:|.:|.|||
Zfish   419 QIEALLHKIEIQMKHQSTSFGLALASYIASLWNHDGDPVQLLKISESVSRFRQCLKENPRYLQEK 483

  Fly   514 IEKYFANNNHRLTLTMSPDEAYEDKFKQAELELVEQKVKLLDEVKIEKIYERGLILDSYQKAESN 578
            ::.||.||.|:|||:|||||.:.:|..:||.:.::||:::|.....:.|||:||.|.:.|....:
Zfish   484 VQHYFKNNTHQLTLSMSPDERFLEKQAEAEEQKLQQKIQILSSEDRKDIYEKGLQLLAVQSTTQD 548

  Fly   579 TDLLPCLTMNDVRDPPKWPKLFIQ--NVQNVRTQICKVPTNEITYFKCMFNITGLSHEETQLMPL 641
            ...||.|.::|:.  |..|...:|  ....|..|.|:.|||.:.||:.|.||..|..:....:||
Zfish   549 ASCLPALKVSDIE--PIIPYTPVQPGAAGGVPVQYCEQPTNGMVYFRAMSNINSLPEDLKIYVPL 611

  Fly   642 FCNVISAMGTTNYNYREFDKHILLKTGGFDFKLHLIEDVRDSKSYSLSVMINTHALNNNVPEMFA 706
            ||:||:.||:...:||:..:.|.|||||......:|.|..|...|...:::::..|..|:|:||.
Zfish   612 FCSVITKMGSGMLDYRQQAQRIELKTGGLSVSPQIIPDTEDLDLYEQGIILSSSCLERNLPDMFQ 676

  Fly   707 LCQELIKNVRFDDSERLKMLIENYISYISVGVASSGHLYAMLGATSQVCDAGKLKSLLYGVDHID 771
            |..:|..:.||||.|||::|:......:|.|::.|||:|||..|...:.....|:....|:|.:.
Zfish   677 LWSDLFNSPRFDDEERLRVLVMMSAQELSNGISYSGHMYAMTRAARSLTPTADLQESFSGMDQVK 741

  Fly   772 FMKNFVHSTSTVDICDKLSTIASKVFNKDNMRGAINTTQSYEPSAISNYEKFLESL--------- 827
            |||.....|....|..||..|...:||.:|||.|:|.|....|...:..|:|:.::
Zfish   742 FMKRIAEMTDLTSILRKLPRIKRHLFNPENMRCALNATPQKMPDVAAEVERFIGNIAGNRKERKP 806

  Fly   828 -----------PTFGKTQTSRNI---HYLDPSCQQ---YVMNIPVNYCAKALFTVPYLHQDHPTL 875
                       |..|...|.:.|   |:  ..||.   :.:...||:.::.:.|||:.|.|:.:|
Zfish   807 VRPSVVERALGPEAGAAATRKLISEAHF--KPCQMKTYFQLPFNVNFVSECVRTVPFTHADYASL 869

  Fly   876 RVLAKLLSAKYLLPVIREKNGAYGAGAKISSDGIFSFYSYRDPNSTKTLNAFDETYKWLRANQNV 940
            .:|.::::||:|...||||.||||.||::...|:||||||||||||:||:||....:|.||.:
Zfish   870 CILGRMMTAKFLHGEIREKGGAYGGGARMGGGGLFSFYSYRDPNSTQTLSAFRGGVEWARAGK-- 932

  Fly   941 IDQQSLFESKLGVLQQLDTPIAPGNIGIDYFLYEVSQEDFESYRSRMLSVTIDDLQCAIENYFGK 1005
            ..||.:.|:||.|...:|.|:||.:.|:..||..::.|..:::|.|:.:||..:|......|.|.
Zfish   933 FTQQDIDEAKLSVFSAVDAPVAPSDKGLGRFLNGITDEMKQAHRERLFAVTERNLIDVAGRYLGI 997

  Fly  1006 ESMHYGKCILGPVNANLELETSHKWII 1032
            .....|..||||.|.::..:.|  |::
Zfish   998 GQQTCGVAILGPENESIRKDPS--WVV 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3107	NP_001036470.1	Cym1	68..1003	CDD:223957	380/962 (40%)
		Peptidase_M16	120..>177	CDD:279066	42/56 (75%)
		Peptidase_M16_C	268..457	CDD:282978	62/188 (33%)
		M16C_assoc	531..773	CDD:285556	82/243 (34%)
pitrm1	NP_998652.1	Cym1	40..1018	CDD:223957	388/984 (39%)
		Peptidase_M16	91..>172	CDD:279066	55/80 (69%)
		Peptidase_M16_C	240..427	CDD:282978	62/187 (33%)
		M16C_assoc	501..743	CDD:285556	82/243 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592687
Domainoid	1	1.000	158	1.000	Domainoid score	I4095
eggNOG	1	0.900	-	-		E1_COG1026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5742
Inparanoid	1	1.050	749	1.000	Inparanoid score	I553
OMA	1	1.010	-	-		QHG63001
OrthoDB	1	1.010	-	-		D107079at2759
OrthoFinder	1	1.000	-	-		FOG0004106
OrthoInspector	1	1.000	-	-		oto38808
orthoMCL	1	0.900	-	-		OOG6_101809
Panther	1	1.100	-	-	LDO	PTHR43016
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R283
SonicParanoid	1	1.000	-	-		X2847
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800