DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3107 and Pitrm1

DIOPT Version :9

Sequence 1:	NP_001036470.1	Gene:	CG3107 / 35475	FlyBaseID:	FBgn0033005	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	XP_006254248.1	Gene:	Pitrm1 / 307081	RGDID:	1310998	Length:	1035	Species:	Rattus norvegicus

Alignment Length:	1029	Identity:	417/1029 - (40%)
Similarity:	593/1029 - (57%)	Gaps:	45/1029 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SGVNTKQPKSPRQFGCMPHVTKKRKYKYEEGKTYHGFQCERVEHISEFELTSYTFRYERTGTELW 101
            |||:.|..:......|      .|..:|:.|:..|||...:|..:.|..||:....::.||....
  Rat    18 SGVHHKVWREKSDQAC------DRALQYKVGEKIHGFTVNQVTPVPELFLTAVKLSHDNTGARYL 76

  Fly   102 HIDRNDSNNVFSINFRTTPFDSTGLPHILEHLSLCGSQKYPVRDPFFKMLNRSVATFMNAMTGPD 166
            |:.|.|:||:||:.|||||.||||:||:|||..||||||||.|||||||||||::|||||.|..|
  Rat    77 HLAREDNNNLFSVQFRTTPMDSTGVPHVLEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASD 141

  Fly   167 YTIYPFSTMNEIDFRNLQHIYLDAVFRPNLAYFDFLQEGWRLENKDIFDKQSKLVIKGVVYNEMK 231
            ||:|||||.|..||:||..:||||.|.|.|...||.|||||||::|..|.|:.|:.||||:||||
  Rat   142 YTMYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHEDPSDPQTPLIFKGVVFNEMK 206

  Fly   232 GAFSENAQVFSQNLLNNIFPDHTYRHVSGGNPLEIPKLAYNDLVEFHKKYYHPSNARIYSYGLFD 296
            |||::|.::|||:|.|.:.|||||..||||:||.||:|.:..|.:||..:|||||||.::||.|.
  Rat   207 GAFTDNERIFSQHLQNKLLPDHTYSVVSGGDPLCIPELTWEQLKQFHTTHYHPSNARFFTYGNFP 271

  Fly   297 ASKTLALLDEEYLSDQSWVDNSYSLIRQQERWTQPRLVHISSRLDNMGTTIDRQNQIAIALLMCD 361
            ....|..:.||.||....::.| :.:..|:.|.:||..||:...|::.|...:|..::::.|:.|
  Rat   272 LEDHLKQIHEEALSKFQKMEES-TAVPAQKYWDKPREFHITCGPDSLATDATKQTTVSVSFLLPD 335

  Fly   362 ATNIQESFELHVLSEVLIRGPNSPFYKNLIEPNFSGGYNQTTGYSSDTKDTTFVVGLQDLRVEDF 426
            .||..|:|.|::||.:||.||||||||.|||......::...||:..|::..|.||||.:...|.
  Rat   336 ITNTFEAFTLNLLSSLLISGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAENDV 400

  Fly   427 KKCIEIFDKTIINSMNDGFDSQHVESVLHNLELSLKHQNPNFGNTLLFNSTALWNHDGDVVSNLR 491
            |...|:.|:||...:..||:...:|::||.:|:.:|||:.:||..|.....:.||||||.|..|:
  Rat   401 KTVRELVDRTIEEVIEKGFEDDQIEALLHKIEIQMKHQSASFGMALTSYIASCWNHDGDPVELLQ 465

  Fly   492 VSDMISGLRESISQNKKYFQEKIEKYFANNNHRLTLTMSPDEAYEDKFKQAELELVEQKVKLLDE 556
            :...::..|:.:.:|.|:.|||:|:||.||.|||||:|.||:.|.:|..|.|.|.:||||..|.:
  Rat   466 MGSQLTKFRKCLKENPKFLQEKVEQYFKNNPHRLTLSMKPDDRYYEKQTQMETEKLEQKVNSLSQ 530

  Fly   557 VKIEKIYERGLILDSYQKAESNTDLLPCLTMNDVRDPPKWPKLFIQ-NVQNVRTQICKVPTNEIT 620
            ...::|||:||.|...|....:...||.|.::|:.....:.|..|. :..:|..|.|..|||.|.
  Rat   531 ADKKQIYEKGLELQKQQSKHQDASCLPALKVSDIEPTMPFTKFDIALSAGDVPVQYCPQPTNGIV 595

  Fly   621 YFKCMFNITGLSHEETQLMPLFCNVISAMGTTNYNYREFDKHILLKTGGFDFKLHLIEDVRDSKS 685
            ||:...::..|..|....:||||.|::.:|....||||..:.|.|||||.....|::.|.....:
  Rat   596 YFRAFSSLNTLPEELRPFVPLFCTVLTKLGCGILNYREQAQQIELKTGGMTVTPHVLPDDSQLDT 660

  Fly   686 YSLSVMINTHALNNNVPEMFALCQELIKNVRFDDSERLKMLIENYISYISVGVASSGHLYAMLGA 750
            |...|:.::..|..|:|:|..|..|:..|..|::.|..|:|:......:|.|:..||||||.|.|
  Rat   661 YEQGVLFSSLCLERNLPDMMHLWSEIFNNPCFEEEEHFKVLVRMSAQELSNGIPDSGHLYAALRA 725

  Fly   751 TSQVCDAGKLKSLLYGVDHIDFMKNFVHSTSTVDICDKLSTIASKVFNKDNMRGAINTTQSYEPS 815
            ...:..||.|:....|:|.:..||.....|....|..||..|...:.|.||||.::|.|....|.
  Rat   726 GKTLTPAGDLQETFSGMDQVKVMKRIAEMTDIKPILRKLPRIKKYLLNCDNMRCSVNATPQQMPQ 790

  Fly   816 AISNYEKFLESL----------------------PTFGK----TQTSRNIHYLDPS---CQ---Q 848
            |....|.||.::                      |:.|.    :|..|.: ..||:   ||   .
  Rat   791 AEKEVENFLRNVGRSKKERKPVRPHIVEKPTPSGPSGGAHADGSQIIRKL-ITDPTFKPCQMKTH 854

  Fly   849 YVMNIPVNYCAKALFTVPYLHQDHPTLRVLAKLLSAKYLLPVIREKNGAYGAGAKISSDGIFSFY 913
            :|:..||||..:.:.||||...||.:|::||:|::||:|...||||.||||.|||::..|||:.|
  Rat   855 FVLPFPVNYVGECVRTVPYADPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKVTHTGIFTLY 919

  Fly   914 SYRDPNSTKTLNAFDETYKWLRANQNVIDQQSLFESKLGVLQQLDTPIAPGNIGIDYFLYEVSQE 978
            |||||||.:||.:|.:...|.::.:  ..||.:.|:||.|...:|:|:||.:.|:|:|||.:|.|
  Rat   920 SYRDPNSIETLQSFGKAIDWAKSGK--FTQQDIDEAKLSVFSAVDSPVAPSDKGMDHFLYGLSDE 982

  Fly   979 DFESYRSRMLSVTIDDLQCAIENYFGKESMHYGKCILGPVNANLELETSHKWII 1032
            ..::||.::.:||.|.|......|.|.....:|..||||.|:.|..:.|  |||
  Rat   983 MKQTYREQLFAVTHDKLTSVSHKYLGIGKSTHGLAILGPENSKLAKDPS--WII 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3107	NP_001036470.1	Cym1	68..1003	CDD:223957	396/967 (41%)
		Peptidase_M16	120..>177	CDD:279066	43/56 (77%)
		Peptidase_M16_C	268..457	CDD:282978	70/188 (37%)
		M16C_assoc	531..773	CDD:285556	82/242 (34%)
Pitrm1	XP_006254248.1	Cym1	43..1007	CDD:223957	396/967 (41%)
		Peptidase_M16	95..>176	CDD:279066	55/80 (69%)
		Peptidase_M16_C	244..431	CDD:282978	70/187 (37%)
		M16C_assoc	505..748	CDD:285556	82/242 (34%)
		Peptidase_M16_C	775..954	CDD:282978	66/181 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350978
Domainoid	1	1.000	152	1.000	Domainoid score	I4230
eggNOG	1	0.900	-	-		E1_COG1026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5742
Inparanoid	1	1.050	774	1.000	Inparanoid score	I507
OMA	1	1.010	-	-		QHG63001
OrthoDB	1	1.010	-	-		D107079at2759
OrthoFinder	1	1.000	-	-		FOG0004106
OrthoInspector	1	1.000	-	-		oto95769
orthoMCL	1	0.900	-	-		OOG6_101809
Panther	1	1.100	-	-	LDO	PTHR43016
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2847
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810