DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3107 and PITRM1

DIOPT Version :9

Sequence 1:	NP_001036470.1	Gene:	CG3107 / 35475	FlyBaseID:	FBgn0033005	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_001229236.1	Gene:	PITRM1 / 10531	HGNCID:	17663	Length:	1038	Species:	Homo sapiens

Alignment Length:	1016	Identity:	395/1016 - (38%)
Similarity:	587/1016 - (57%)	Gaps:	55/1016 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 KRKYKYEEGKTYHGFQCERVEHISEFELTSYTFRYERTGTELWHIDRNDSNNVFSINFRTTPFDS 123
            :|..:|:.|...|||...:|..:.|..||:....::.||....|:.|.|:||:||:.|||||.||
Human    35 ERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDS 99

  Fly   124 TGLPHILEHLSLCGSQKYPVRDPFFKMLNRSVATFMNAMTGPDYTIYPFSTMNEIDFRNLQHIYL 188
            ||:||||||..||||||||.|||||||||||::|||||.|..|||:|||||.|..||:||..:||
Human   100 TGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYL 164

  Fly   189 DAVFRPNLAYFDFLQEGWRLENKDIFDKQSKLVIKGVVYNEMKGAFSENAQVFSQNLLNNIFPDH 253
            ||.|.|.|...||.|||||||:::..|.|:.||.||||:|||||||::|.::|||:|.|.:.|||
Human   165 DATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDH 229

  Fly   254 TYRHVSGGNPLEIPKLAYNDLVEFHKKYYHPSNARIYSYGLFDASKTLALLDEEYLSDQSWVDNS 318
            ||..||||:||.||:|.:..|.:||..:|||||||.::||.|...:.|..:.||.||....::.|
Human   230 TYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPS 294

  Fly   319 YSLIRQQERWTQPRLVHISSRLDNMGTTIDRQNQIAIALLMCDATNIQESFELHVLSEVLIRGPN 383
             :::..|..|.:||...|:...|:..|...:|..|:::.|:.|.|:..|:|.|.:||.:|..|||
Human   295 -TVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPN 358

  Fly   384 SPFYKNLIEPNFSGGYNQTTGYSSDTKDTTFVVGLQDLRVEDFKKCIEIFDKTIINSMNDGFDSQ 448
            |||||.|||......::...||:..|::..|.||||.:..:|.:....:.|:||...:..||:..
Human   359 SPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDD 423

  Fly   449 HVESVLHNLELSLKHQNPNFGNTLLFNSTALWNHDGDVVSNLRVSDMISGLRESISQNKKYFQEK 513
            .:|::||.:|:.:|||:.:||..|.....:.||||||.|..|::.:.::..|:.:.:|.|:.|||
Human   424 RIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEK 488

  Fly   514 IEKYFANNNHRLTLTMSPDEAYEDKFKQAELELVEQKVKLLDEVKIEKIYERGLILDSYQKAESN 578
            :::||.||.|:|||:|.||:.|.:|..|.|...::|||:.|.....::|||:||.|.|.|....:
Human   489 VKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQD 553

  Fly   579 TDLLPCLTMNDVRDPPKWPKLFIQNVQNVRT------QICKVPTNEITYFKCMFNITGLSHEETQ 637
            ...||.|.::|:.     |.:.:..:..|.|      |.|..|||.:.||:...::..|..|...
Human   554 ASCLPALKVSDIE-----PTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRP 613

  Fly   638 LMPLFCNVISAMGTTNYNYREFDKHILLKTGGFDFKLHLIEDVRDSKSY-SLSVMINTHALNNNV 701
            .:||||:|::.:|....:|||..:.|.|||||.....|::.|.....:| .:.|:.::..|:.|:
Human   614 YVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQVGVLFSSLCLDRNL 678

  Fly   702 PEMFALCQELIKNVRFDDSERLKMLIENYISYISVGVASSGHLYAMLGATSQVCDAGKLKSLLYG 766
            |:|..|..|:..|..|::.|..|:|::.....::.|:..||||||.:.|...:..||.|:....|
Human   679 PDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSG 743

  Fly   767 VDHIDFMKNFVHSTSTVDICDKLSTIASKVFNKDNMRGAINTTQSYEPSAISNYEKFLESLPTFG 831
            :|.:..||.....|....|..||..|...:.|.||||.::|.|....|......|.||.|:   |
Human   744 MDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSI---G 805

  Fly   832 KTQTSR------------------NIH-----------YLDPSCQ------QYVMNIPVNYCAKA 861
            :::..|                  :.|           .::|:.:      .::|..||||..:.
Human   806 RSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGEC 870

  Fly   862 LFTVPYLHQDHPTLRVLAKLLSAKYLLPVIREKNGAYGAGAKISSDGIFSFYSYRDPNSTKTLNA 926
            :.||||...||.:|::||:|::||:|...||||.||||.|||:|.:|||:.|||||||:.:||.:
Human   871 IRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQS 935

  Fly   927 FDETYKWLRANQNVIDQQSLFESKLGVLQQLDTPIAPGNIGIDYFLYEVSQEDFESYRSRMLSVT 991
            |.:...|.::.:  ..||.:.|:||.|...:|.|:||.:.|:|:|||.:|.|..:::|.::.:|:
Human   936 FGKAVDWAKSGK--FTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVS 998

  Fly   992 IDDLQCAIENYFGKESMHYGKCILGPVNANLELETSHKWII 1032
            .|.|....:.|.|.....:|..||||.|..:..:.|  |||
Human   999 HDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPS--WII 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3107	NP_001036470.1	Cym1	68..1003	CDD:223957	380/976 (39%)
		Peptidase_M16	120..>177	CDD:279066	44/56 (79%)
		Peptidase_M16_C	268..457	CDD:282978	66/188 (35%)
		M16C_assoc	531..773	CDD:285556	77/248 (31%)
PITRM1	NP_001229236.1	Cym1	44..1010	CDD:223957	380/976 (39%)
		Peptidase_M16	71..>177	CDD:279066	69/105 (66%)
		Peptidase_M16_C	245..432	CDD:282978	66/187 (35%)
		M16C_assoc	506..750	CDD:285556	77/248 (31%)
		Peptidase_M16_C	769..957	CDD:282978	64/192 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	805..835		3/29 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157022
Domainoid	1	1.000	141	1.000	Domainoid score	I4737
eggNOG	1	0.900	-	-		E1_COG1026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5742
Inparanoid	1	1.050	745	1.000	Inparanoid score	I589
Isobase	1	0.950	-	0	Normalized mean entropy	S1786
OMA	1	1.010	-	-		QHG63001
OrthoDB	1	1.010	-	-		D107079at2759
OrthoFinder	1	1.000	-	-		FOG0004106
OrthoInspector	1	1.000	-	-		oto88637
orthoMCL	1	0.900	-	-		OOG6_101809
Panther	1	1.100	-	-	LDO	PTHR43016
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R283
SonicParanoid	1	1.000	-	-		X2847
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750