DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TpnC41C and CAPS

DIOPT Version :9

Sequence 1:	NP_001246139.1	Gene:	TpnC41C / 35473	FlyBaseID:	FBgn0013348	Length:	154	Species:	Drosophila melanogaster
Sequence 2:	NP_004049.3	Gene:	CAPS / 828	HGNCID:	1487	Length:	189	Species:	Homo sapiens

Alignment Length:	139	Identity:	37/139 - (26%)
Similarity:	60/139 - (43%)	Gaps:	29/139 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LSMLGHQLDDATLADIIAEVDEDGSGQIEFEEFTTLAARFLVEEDAEAMMAELKEAFRLYDKEGN 101
            |:.||..||.|....:..:.|.:|||.::.|||    .|.|....::|..|.:..||...|:.|:
Human    50 LAKLGLVLDQAEAEGVCRKWDRNGSGTLDLEEF----LRALRPPMSQAREAVIAAAFAKLDRSGD 110

  Fly   102 GYITTGVLR-------------------EILRELDDKLTNDDLDMMI-----EEIDSDGSGTVDF 142
            |.:|...||                   |:||...|...:.:.|..:     ::..|..|.:::.
Human   111 GVVTVDDLRGVYSGRAHPKVRSGEWTEDEVLRRFLDNFDSSEKDGQVTLAEFQDYYSGVSASMNT 175

  Fly   143 D-EFMEVMT 150
            | ||:.:||
Human   176 DEEFVAMMT 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TpnC41C	NP_001246139.1	PTZ00184	1..150	CDD:185504	35/137 (26%)
CAPS	NP_004049.3	EFh_PI-PLC	26..165	CDD:333715	30/118 (25%)
		EFh	26..87	CDD:238008	14/40 (35%)
		EF-hand motif	26..54	CDD:320029	1/3 (33%)
		EF-hand motif	61..89	CDD:320029	9/31 (29%)
		EF-hand motif	94..131	CDD:320029	9/36 (25%)
		EF-hand motif	139..165	CDD:320029	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148551
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930