Protein Alignment Tif-IA and RRN3

DIOPT Version :10

• Sequence 1: NP_788084.1
• Gene: Tif-IA / 35454
• FlyBaseID: FBgn0032988
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_060897.3
• Gene: RRN3 / 54700
• HGNCID: 30346
• Length: 651
• Species: Homo sapiens
• Alignment Length: 656
• Identity: 200/656 - (30%)
• Similarity: 323/656 - (49%)
• Gaps: 94/656 - (14%)

  Fly    18 SGVKRNQANAVAINKVR------FSTPKEK-----GLAESVRVAL---EERNFHLVKEFTYFLRE 68
            |.||:..|:...|:.:|      |::|..|     |....|.:..   |..:|.|:|.   .|.:
Human    19 SAVKKLGASRTGISNMRALENDFFNSPPRKTVRFGGTVTEVLLKYKKGETNDFELLKN---QLLD 80

  Fly    69 AELSDDEVVIIIKDAKRIVHNLTPEFVTVVEALLSLNWKKRSSEIIEAYTEFCIELMVTHNRYLP 133
            .::.||:::..:.:.:..:..||.:|..::..:|.|.|..||..::|.|..|...|:.....:|.
Human    81 PDIKDDQIINWLLEFRSSIMYLTKDFEQLISIILRLPWLNRSQTVVEEYLAFLGNLVSAQTVFLR 145

  Fly   134 IGVSKLIVHWIP-------GDMDESDWVHGCPSEHVRNELKPIHKVLDRILTAVPMAFDIIIDAI 191
            ..:|.:..|::|       ||:|.||  .....:::.......|:.|..|...||.....::..:
Human   146 PCLSMIASHFVPPRVIIKEGDVDVSD--SDDEDDNLPANFDTCHRALQIIARYVPSTPWFLMPIL 208

  Fly   192 SAKFPYFKKPYHVTAGYLYNVLWLLEYKPIFEELVFQLVLQKLLLLDVNAPKDEIE--------- 247
            ..|||:.:|.......|::|:|.:..|.|.....:.:|:::|||.|||||.:..||
Human   209 VEKFPFVRKSERTLECYVHNLLRISVYFPTLRHEILELIIEKLLKLDVNASRQGIEDAEETATQT 273

  Fly   248 ---------LEMNDEEEKVEADTLFEIDDVCAENVPKSEKSVSHPVGKTLDVCLFLLYKFFDGKC 303
                     |...||:|:.|.:|         :..|:....:.|||.:.||:.:.|:..:....|
Human   274 CGGTDSTEGLFNMDEDEETEHET---------KAGPERLDQMVHPVAERLDILMSLVLSYMKDVC 329

  Fly   304 RLNENSSEEQRRTANRLFKMLLYLFDEVLLPSHNTHHVQFILFYATSLRSVYSEAFLDSLWTKVQ 368
            .:  :...:..:|.: |::.|:.:||::|||:|.:.||||.:||..|.:..::||||:.||.|:|
Human   330 YV--DGKVDNGKTKD-LYRDLINIFDKLLLPTHASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQ 391

  Fly   369 NPNVSAVIRHAAVGYMASFLSRARFLPLSTVTFYLKELTRWAHTYIDDSDA-YKQNCSLKANLVF 432
            :|:..|:||.||..|:.|||:||:|:||.||...|..|..|.|.|:::.|: .|..|.:..:..|
Human   392 DPSNPAIIRQAAGNYIGSFLARAKFIPLITVKSCLDLLVNWLHIYLNNQDSGTKAFCDVALHGPF 456

  Fly   433 YSVCQAVFYLIAFRAKDLTASS--KDLLFLQSLQLSRLAMCHLNPLRYCLAPVATAFAGVTRTYQ 495
            ||.||||||...||.|.|.:.:  :.|.:||||...|:.|..||||:.||..|...||.:|..||
Human   457 YSACQAVFYTFVFRHKQLLSGNLKEGLQYLQSLNFERIVMSQLNPLKICLPSVVNFFAAITNKYQ 521

  Fly   496 LAYCHTVLERNARRKL----ATVYGHEKCMPDETLESFFPFDPYVLKLSKKYIETNYMVYQSNDT 556
            |.:|:|::|||.|:.|    :|..|....:....|::||||||.|||.|||:|:..|.|::....
Human   522 LVFCYTIIERNNRQMLPVIRSTAGGDSVQICTNPLDTFFPFDPCVLKRSKKFIDPIYQVWEDMSA 586

  Fly   557 DEYVYGSNKYGHSRKRGDSEMLEEDEFL---------IVDKRPKNFDLSKSQEFDKQFHF----- 607
            :|.    .::....|: |....|:|:||         ::...|.:||.          ||
Human   587 EEL----QEFKKPMKK-DIVEDEDDDFLKGEVPQNDTVIGITPSSFDT----------HFRSPSS 636

  Fly   608 --GSSP 611
              ||.|
Human   637 SVGSPP 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tif-IA	NP_788084.1	RRN3	39..556	CDD:461623	177/556 (32%)
RRN3	NP_060897.3	RRN3	60..585	CDD:461623	174/541 (32%)
		Interaction with POLR1F. /evidence=ECO:0000269|PubMed:12393749	500..651		52/158 (33%)
		Interaction with EIF3L. /evidence=ECO:0000269|PubMed:12393749	557..651		30/101 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	624..651		8/29 (28%)