Protein Alignment Tif-IA and rrn3

DIOPT Version :9

• Sequence 1: NP_788084.1
• Gene: Tif-IA / 35454
• FlyBaseID: FBgn0032988
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_001342810.1
• Gene: rrn3 / 2542511
• PomBaseID: SPAC18G6.11c
• Length: 599
• Species: Schizosaccharomyces pombe
• Alignment Length: 654
• Identity: 158/654 - (24%)
• Similarity: 271/654 - (41%)
• Gaps: 147/654 - (22%)

  Fly     1 MSFYTSKTDVTSILKTF-SGVKRNQANAVAINKVRFSTPKEKGLAESVRVALEER---NF----H 57
            |:..|:..|.|...|:| |.|.:|....:           ::.|...|..||:::   ||    .
pombe    22 MASSTNVPDRTVGSKSFASSVSKNDGRLM-----------QQMLRAFVNKALDDKAEGNFAGYED 75

  Fly    58 LVKEFTYFLREAELSDDEVVIIIKDAKRI--VHNLTPEFVTVVEALLSLN-----------WKKR 109
            |.::|      |..||      .|||...  :.||.......|..|.|.|           |..|
pombe    76 LRRQF------AAKSD------TKDAPSSLQLQNLLSALTCNVSRLDSSNSSLVMSVLDSVWVSR 128

  Fly   110 SSEIIEAYTEFCIELMVTHNRYLPIGVSKLIVHWI--PGDMDESDWVHGCPSEHVRNELKPIHKV 172
            ....:..||.|...|:...:.|||:.::.||.|.:  |    :|..:|   .||.       |..
pombe   129 DESFVRCYTRFLGNLISAQSNYLPLVMTMLIQHMLYRP----DSLAIH---YEHA-------HMA 179

  Fly   173 LDRILTAVPMAFDIIIDAISAKFPYFKKPYHVTAGYLYNVLWLLEYKPIFEELVFQLVLQKLLLL 237
            |..:|..||.|...:..:|..:|||..:.......|:.|||.:.||.|..:..|...::.|::.:
pombe   180 LKYVLELVPRAHSFLYSSILEEFPYKDESLLAQMTYISNVLSICEYVPSIKGPVLHAIIDKIIQI 244

  Fly   238 DVNAPKDEIELEMNDEEEK------------------VEADTLFEIDDVCAENVPKSEKSVSHPV 284
            ||     ||::|::|::|:                  :.|.||:|.....:..:..|  ::..|.
pombe   245 DV-----EIQVEVDDDDEEEDEVVTDDDGTSNADSEVITASTLYERHTAISSEMTSS--TILTPP 302

  Fly   285 GKT--------LDVCLFLLYKFFDGKCRLNENSSEEQRRTANRLFKMLLYLFDEVLLPSHNTHHV 341
            ..|        ||..|:.|:.:.|...:   ::|.::....|.|.|.    |...:|.:....:.
pombe   303 SLTDTRQLMQQLDQLLYTLFSYLDSNLK---STSRDRYLVYNSLIKS----FVNTVLKTFRCRYT 360

  Fly   342 QFILFYATSLRSVYSEAFLDSLWTKVQNPNVSAVIRHAAVGYMASFLSRARFLPLSTVTFYLKEL 406
            ||::|:|:.|...:::.||..|.....:|:....:|.:...|:.|:::||:.|..:|:...:..:
pombe   361 QFLIFWASQLDPEFTDIFLGVLTEVCLDPSQPYTLRLSGAMYIGSYVARAKALEKNTIQIIVNMM 425

  Fly   407 TRWAHTYIDDSDAYKQNCSLKANLVFYSVCQAVFYLIAFRAKDLTASSKDLLFLQSLQ------- 464
            |||...|:|..:....:..|..:.|||::.|::||:..||.::|..|.:.    :|::
pombe   426 TRWVEAYLDQCENELSDDLLSKHSVFYAINQSIFYIFCFRWRELCVSDES----ESMEPRPNEWI 486

  Fly   465 -----LSRLAMCHLNPLRYCLAPVATAFAGVTRTYQLAYCHTVLERNARRKLATVYGHEKCMPDE 524
                 |.|..:..|||||||...:...||.|.......|.::::|:|.:......:        :
pombe   487 PGLEILHRSVLSRLNPLRYCSPNIVLQFAKVANHLNFMYVYSIIEQNRKGIFREGF--------D 543

  Fly   525 TLESFFPFDPYVLKLSKKYIETNYMVYQ----------SNDTDEYVYGSNKYGHSRKRGDSEMLE 579
            |::::||||||.|..|...::..|..:|          ..|||   |.|:          :.||.
pombe   544 TMDAYFPFDPYRLTKSSIIVQPFYNEWQQIPGLDDDEEEEDTD---YESS----------TVMLG 595

  Fly   580 EDEF 583
            |..|
pombe   596 ESPF 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tif-IA	NP_788084.1	RRN3	40..553	CDD:283082	140/582 (24%)
rrn3	NP_001342810.1	RRN3	51..575	CDD:310142	140/575 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	162	1.000	Domainoid score	I966
eggNOG	1	0.900	-	-		E1_KOG2434
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39531
Inparanoid	1	1.050	162	1.000	Inparanoid score	I1235
OMA	1	1.010	-	-		QHG55528
OrthoFinder	1	1.000	-	-		FOG0002748
OrthoInspector	1	1.000	-	-		oto101794
orthoMCL	1	0.900	-	-		OOG6_102817
Panther	1	1.100	-	-	LDO	PTHR12790
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1213
SonicParanoid	1	1.000	-	-		X2132
TreeFam	1	0.960	-	-
	14	13.860