DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tif-IA and Rrn3

DIOPT Version :9

Sequence 1:	NP_788084.1	Gene:	Tif-IA / 35454	FlyBaseID:	FBgn0032988	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001034610.1	Gene:	Rrn3 / 106298	MGIID:	1925255	Length:	656	Species:	Mus musculus

Alignment Length:	665	Identity:	208/665 - (31%)
Similarity:	332/665 - (49%)	Gaps:	99/665 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DVTSILK-TFSGVKRNQANAVAINKVRFSTPKEK-----GLAESVRVAL---EERNFHLVKEFTY 64
            |||:... |.|..:...::.:|:....|::|.:|     |....|.:..   |..:..|:|.
Mouse    13 DVTAAASATLSASRTGLSDMLALESDFFNSPPKKTVRFGGTVTEVLLKYKKGETNDLELLKN--- 74

  Fly    65 FLREAELSDDEVVIIIKDAKRIVHNLTPEFVTVVEALLSLNWKKRSSEIIEAYTEFCIELMVTHN 129
            .|.:.::.||:::..:.:.:..|..||.:|..::..:|.|.|..||..::|.|..|...|:....
Mouse    75 QLSDPDIKDDQIINWLLEFRSSVMYLTKDFEQLINIILRLPWLNRSQRVVEEYLAFLGNLVSAQT 139

  Fly   130 RYLPIGVSKLIVHWIP-------GDMDESDWVHGCPSEHVRNELKPI----HKVLDRILTAVPMA 183
            .:|...:|.:..|::|       |.:|.||      |:...:.|..|    |:.|..|...||..
Mouse   140 VFLRPCLSMIASHFVPPRVIVKEGGIDVSD------SDDEDDNLPAIFDTCHRALQIITRYVPST 198

  Fly   184 FDIIIDAISAKFPYFKKPYHVTAGYLYNVLWLLEYKPIFEELVFQLVLQKLLLLDVNAPKDEIEL 248
            ...::..:..|||:.:|.......|::|:|.:..|.|.....:.:||::|||.|||:..:.:||
Mouse   199 PWFLMPILVEKFPFVRKSERTLECYVHNLLRISLYFPTLRREILELVIEKLLKLDVSVSRQDIE- 262

  Fly   249 EMNDEEEKVE-----ADT---LFEID---DVCAENVPKSEK--SVSHPVGKTLDVCLFLLYKFFD 300
               |.|||..     .||   ||.:|   |...|.....|:  .::||..:.|||.|.||..:.:
Mouse   263 ---DAEEKAAQTCGGTDTTEGLFNMDEDEDTDPEKKADQEQPNQMAHPTAERLDVLLCLLLSYIE 324

  Fly   301 GKCR----LNENSSEEQRRTANRLFKMLLYLFDEVLLPSHNTHHVQFILFYATSLRSVYSEAFLD 361
            ..||    ::.|.:::       |::.|:.:||::|||:|.:.||||.:|:..|.:..::||||:
Mouse   325 DVCRVHGKIDNNKTKD-------LYRDLISIFDKLLLPTHASCHVQFFMFFLCSFKLGFAEAFLE 382

  Fly   362 SLWTKVQNPNVSAVIRHAAVGYMASFLSRARFLPLSTVTFYLKELTRWAHTYIDDSDA-YKQNCS 425
            .||.|:|:||..|:||.||..|:.|||:||:|:||.||...|..|..|.|.|:.:.|: .|..|.
Mouse   383 HLWKKLQDPNNPAIIRQAAANYIGSFLARAKFIPLITVKTCLDLLVNWLHMYLTNQDSGTKAFCD 447

  Fly   426 LKANLVFYSVCQAVFYLIAFRAKDLTASS--KDLLFLQSLQLSRLAMCHLNPLRYCLAPVATAFA 488
            :..:..|||.||||||.:.||.|.|.:.:  :.|.:||||...|:.:..||||:.||..|...||
Mouse   448 VALHGPFYSACQAVFYTVVFRHKQLLSGNLKQGLQYLQSLNFERIVLSQLNPLKICLPQVVNFFA 512

  Fly   489 GVTRTYQLAYCHTVLERNARRKL----ATVYGHEKCMPDETLESFFPFDPYVLKLSKKYIETNYM 549
            .:|..|||.:|:|::|||:|:.|    :|..|.........|::||||||.|||.|||:|:..|.
Mouse   513 AITNKYQLVFCYTIMERNSRQMLPVIRSTAGGDSVQTCTNPLDTFFPFDPCVLKRSKKFIDPIYQ 577

  Fly   550 VYQSNDTDEYVYGSNKYGHSRKRGDSEML--EEDEFL---------IVDKRPKNFDLSKSQEFDK 603
            :::....:|.    .::..|.|:   |::  |:|:||         :....|.:||.
Mouse   578 IWEDGSAEEL----QEFKKSTKK---EVVEDEDDDFLKGEVPQSDTVTGLTPSSFDT-------- 627

  Fly   604 QFHF-------GSSP 611
              ||       ||.|
Mouse   628 --HFQSPSSSVGSPP 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tif-IA	NP_788084.1	RRN3	40..553	CDD:283082	184/555 (33%)
Rrn3	NP_001034610.1	RRN3	58..581	CDD:283082	181/542 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..304		11/38 (29%)
		Interaction with POLR1F. /evidence=ECO:0000250	498..650		52/160 (33%)
		Interaction with EIF3L. /evidence=ECO:0000250	555..650		30/103 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	608..641		8/43 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842671
Domainoid	1	1.000	286	1.000	Domainoid score	I1598
eggNOG	1	0.900	-	-		E1_KOG2434
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39531
Inparanoid	1	1.050	293	1.000	Inparanoid score	I2749
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55528
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002748
OrthoInspector	1	1.000	-	-		oto94619
orthoMCL	1	0.900	-	-		OOG6_102817
Panther	1	1.100	-	-	LDO	PTHR12790
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1213
SonicParanoid	1	1.000	-	-		X2132
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790