Protein Alignment Ir40a and gria1a

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_991161.1
• Gene: gria1a / 798689
• ZFINID: ZDB-GENE-020125-1
• Length: 914
• Species: Danio rerio
• Alignment Length: 635
• Identity: 122/635 - (19%)
• Similarity: 228/635 - (35%)
• Gaps: 142/635 - (22%)

  Fly   141 ARWPPSSRVIRFREPLRVVVVT-------RPRKKAFRIYYNQARPCSDSQLQLVNWYDGDNLGLQ 198
            |.|.....:.|..:.:|:..:|       :.|:..:.|...:.||....:   |.:::.|...:.
Zfish   327 APWGQGIDIQRALQQVRIEGLTGHIQFNEKGRRTNYSISVMELRPTGPKK---VGYWNEDEKFVS 388

  Fly   199 RIPLLPTALSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTGGRDH 263
            ....:|.:...| ..:.||:.|......|:..:.      :..|.|...|..|        |...
Zfish   389 TAAYMPGSNETY-GLQNRTYIVTTILESPYVMLK------KNHEHFTGNDKYE--------GYCV 438

  Fly   264 RLLMLLSKHMNFRF--KYIEAPGRTQGSMRSEDGK-DSNDSFT----GGIGLLQSGQADFFLGDV 321
            .|...::||:.:.:  |.:            .||| .:.|:.|    |.:|.|..|:||..:..:
Zfish   439 ELAAEIAKHVGYHYILKIV------------ADGKYGARDAETMMWNGMVGELVYGKADVAVAPL 491

  Fly   322 GLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEAL-AIMRPFKQDIWPHLILTIIFSGPIFYG 383
            .::..|.:.|:||  |.:|..|  .....|.:....: :.:.|...:||    :.|:|:   :.|
Zfish   492 TITLVREEVIDFSKPFMSLGIS--IMIKKPTKSKPGVFSFLDPLAYEIW----MCIVFA---YIG 547

  Fly   384 IIALPYIWRR----RWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQ---- 440
            :..:.::..|    .|...|.|...|                 ..|....|:...|.|..|
Zfish   548 VSVVLFLVSRFSPYEWHADDCEDGAE-----------------ENPNQPSSSSAQPGQNQQNQNQ 595

  Fly   441 ------------KCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFAR 493
                        ..:||:|..|::|.|:........:.:..|:|. .|.::...|:|.|.:....
Zfish   596 QSQEQTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWF-FTLIIISSYTANLAAFLTV 659

  Fly   494 PAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALMRQQVINDPQGFFIDS 558
            .....||.:.:.| |......|.. ::..|:......:...:|.::::.|:..   || ..|:.:
Zfish   660 ERMVSPIESAEDL-AKQTEIAYGT-LDAGSTKEFFRRSKIAVFEKMWSYMKSA---DP-SVFVKT 718

  Fly   559 VEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVL 623
            .:.|:..:.:.....|.|.......:..|:...:..::...|.::...:|...|.|....:|..:
Zfish   719 TDEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSPLRNPVNLAV 783

  Fly   624 MQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTE-------SYDSTVISPLNL 681
            ::|.|.|:|||:                        ||...|.:.|       |.|.|  |.|:|
Zfish   784 LKLNEQGLLDKL------------------------KNKWWYDKGECGSGGGDSKDKT--SALSL 822

  Fly   682 RMLQGAFIALGVGSLA-AGVILLLEIVFIKLDQARLW-------MLCSRL 723
            ..:.|.|..| :|.|. |.::.|:|..:....::|..       |.||.|
Zfish   823 SNVAGVFYIL-IGGLGLAMLVALVEFCYKSRTESRRMKQSINDAMHCSTL 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	19/79 (24%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	22/100 (22%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	26/140 (19%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_type1	26..390	CDD:471960	11/65 (17%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	89/484 (18%)
		Lig_chan	536..835	CDD:459656	66/356 (19%)