DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir40a and gria1a

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_991161.1	Gene:	gria1a / 798689	ZFINID:	ZDB-GENE-020125-1	Length:	914	Species:	Danio rerio

Alignment Length:	635	Identity:	122/635 - (19%)
Similarity:	228/635 - (35%)	Gaps:	142/635 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 ARWPPSSRVIRFREPLRVVVVT-------RPRKKAFRIYYNQARPCSDSQLQLVNWYDGDNLGLQ 198
            |.|.....:.|..:.:|:..:|       :.|:..:.|...:.||....:   |.:::.|...:.
Zfish   327 APWGQGIDIQRALQQVRIEGLTGHIQFNEKGRRTNYSISVMELRPTGPKK---VGYWNEDEKFVS 388

  Fly   199 RIPLLPTALSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTGGRDH 263
            ....:|.:...| ..:.||:.|......|:..:.      :..|.|...|..|        |...
Zfish   389 TAAYMPGSNETY-GLQNRTYIVTTILESPYVMLK------KNHEHFTGNDKYE--------GYCV 438

  Fly   264 RLLMLLSKHMNFRF--KYIEAPGRTQGSMRSEDGK-DSNDSFT----GGIGLLQSGQADFFLGDV 321
            .|...::||:.:.:  |.:            .||| .:.|:.|    |.:|.|..|:||..:..:
Zfish   439 ELAAEIAKHVGYHYILKIV------------ADGKYGARDAETMMWNGMVGELVYGKADVAVAPL 491

  Fly   322 GLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEAL-AIMRPFKQDIWPHLILTIIFSGPIFYG 383
            .::..|.:.|:||  |.:|..|  .....|.:....: :.:.|...:||    :.|:|:   :.|
Zfish   492 TITLVREEVIDFSKPFMSLGIS--IMIKKPTKSKPGVFSFLDPLAYEIW----MCIVFA---YIG 547

  Fly   384 IIALPYIWRR----RWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQ---- 440
            :..:.::..|    .|...|.|...|                 ..|....|:...|.|..|
Zfish   548 VSVVLFLVSRFSPYEWHADDCEDGAE-----------------ENPNQPSSSSAQPGQNQQNQNQ 595

  Fly   441 ------------KCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFAR 493
                        ..:||:|..|::|.|:........:.:..|:|. .|.::...|:|.|.:....
Zfish   596 QSQEQTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWF-FTLIIISSYTANLAAFLTV 659

  Fly   494 PAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALMRQQVINDPQGFFIDS 558
            .....||.:.:.| |......|.. ::..|:......:...:|.::::.|:..   || ..|:.:
Zfish   660 ERMVSPIESAEDL-AKQTEIAYGT-LDAGSTKEFFRRSKIAVFEKMWSYMKSA---DP-SVFVKT 718

  Fly   559 VEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVL 623
            .:.|:..:.:.....|.|.......:..|:...:..::...|.::...:|...|.|....:|..:
Zfish   719 TDEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSPLRNPVNLAV 783

  Fly   624 MQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTE-------SYDSTVISPLNL 681
            ::|.|.|:|||:                        ||...|.:.|       |.|.|  |.|:|
Zfish   784 LKLNEQGLLDKL------------------------KNKWWYDKGECGSGGGDSKDKT--SALSL 822

  Fly   682 RMLQGAFIALGVGSLA-AGVILLLEIVFIKLDQARLW-------MLCSRL 723
            ..:.|.|..| :|.|. |.::.|:|..:....::|..       |.||.|
Zfish   823 SNVAGVFYIL-IGGLGLAMLVALVEFCYKSRTESRRMKQSINDAMHCSTL 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	29/130 (22%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	22/100 (22%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	26/140 (19%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_Type_1	26..387	CDD:299141	11/62 (18%)
		ANF_receptor	36..369	CDD:279440	7/41 (17%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	89/484 (18%)
		Lig_chan	536..836	CDD:278489	67/357 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591478
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840