DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir40a and grid1a

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_021323097.1	Gene:	grid1a / 793756	ZFINID:	ZDB-GENE-120411-28	Length:	1044	Species:	Danio rerio

Alignment Length:	834	Identity:	161/834 - (19%)
Similarity:	259/834 - (31%)	Gaps:	272/834 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LNSTRLTFIG-----------NDESDTAIALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVY 70
            ||...:|.:.           :.|.|        ||||:                |...:...:.
Zfish   149 LNDVMITLVSELRWHKFIVFYDSEYD--------VRGLR----------------GFLDQASRMG 189

  Fly    71 LDDFLQRLHRSNYK--SVVFS-----------------------QTELFFQH--IEENLQG---- 104
            ||..||::.|:..|  |.:||                       :|...|.|  :|.||..
Zfish   190 LDVSLQQVDRNVTKVFSTLFSTMRMEELNRYRDTLRRAILLLSPRTAQVFIHQAVETNLASKDSH 254

  Fly   105 ---ANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPPSSRVIRFREPLRVVVVTRPRK 166
               |||.:|     ..:::..:|.. || |::               |||...||......|..:
Zfish   255 WVYANEEVS-----DTEIMELVHSA-LG-RMT---------------VIRQIFPLWRDTNIRCMR 297

  Fly   167 KAFRIY---------YNQARPCS-----DSQLQLVN----------WYDGDNLGLQRIPLLP--- 204
            ...||.         |.|:...|     ||.|.|.|          |:...:|...|....|
Zfish   298 NNHRISSLLCDPQEGYLQSLEVSSLYLYDSVLMLANAFYRKLEDRKWHSMASLNCMRKSTKPWNG 362

  Fly   205 -------------TALSVYANFK-----------------GRTFRVPVFHSPPWFWVTYCNNSFE 239
                         :.|:...:|:                 ..||...|.....|......|.|..
Zfish   363 GWSMLDTIQKGRISGLTGLMDFRSNGANSHVQFEILGTSYSETFGKDVKRLATWDSDRGLNGSLR 427

  Fly   240 EDEEFNSLDSIEKRKVRVTG-----------GRDHR-------LLMLLSKHMNFRFKYIEAPGRT 286
            |:...:.:..|..:.|.:..           |:..|       :|..|:|.:.|:::..:.....
Zfish   428 ENRADHGMQGITLKVVTLLEEPFVMVAENILGQPKRYKGFSIDVLDALAKILGFKYEMYQVADAK 492

  Fly   287 QGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFSFFTLADS-GAFATHAPR 350
            .||      ..:|.|:.|.||.|...:||..:..:.::.||...::||...|..| |...|....
Zfish   493 YGS------PQTNGSWNGMIGELIGKRADVAISAITITPERENVVDFSKRYLDYSVGILMTKTEE 551

  Fly   351 RLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGIIALPYIWRR----RWANSDVEHLGELYIHMT 411
            ||| ..:::.||...:|..:...|...|       .:.::.||    |..|....|
Zfish   552 RLN-IFSLLAPFDLAVWACIAAAIPVVG-------VMVFLLRRVQSVRSQNPPGPH--------- 599

  Fly   412 YLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAAT 476
                        :|.:|.::       ||..||.....|::|......:....:.....:|: .|
Zfish   600 ------------QPASVTTS-------FQSAIWIVYGAFVQQGGESFMSSMALRIAMGSWWL-FT 644

  Fly   477 YVLADVYSAQLTSQFARPAREPPINTLQRL-QAAMIHDG-------YRLYVEKESSSLEMLENGT 533
            .::...|:|.|.:.......:..|.|.|.| :.:.|:.|       :..:..|.::.||......
Zfish   645 LIVCSSYTANLAAYLTVSRMDNAIRTFQDLSKQSEINYGTVRESAVFEYFRVKGTNPLEQDSTFA 709

  Fly   534 ELFRQLYALMRQ------------QVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNV 586
            ||:|.:.....|            :|..||..|..|........:.:......|.|.
Zfish   710 ELWRTINKNQGQDNSVTSPAEGIRKVKRDPYAFLWDMAVLEYAALTDDDCTLVVTGN-------- 766

  Fly   587 QQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATR 651
                    .:|.|.|    .:|:|.|.|:....:..::.|.|.|.||.:....:.:
Zfish   767 --------GMSSKGY----GLALQHGSPYRDLFSQKILDLQEKGDLDILKQKWWPR--------- 810

  Fly   652 IYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLAAGVILLLE 705
              ||.... :..|..:||.      ..|.|....|.|..|..|.|.|.::..||
Zfish   811 --KGRCDL-DKHAEPQTEG------RALRLHSFAGVFCILAAGLLLACLVAALE 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	29/139 (21%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	24/94 (26%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	32/160 (20%)
grid1a	XP_021323097.1	Periplasmic_Binding_Protein_Type_1	25..424	CDD:324556	59/320 (18%)
		PBP2_iGluR_delta_1	437..809	CDD:270448	84/434 (19%)
		DNA_pol3_gamma3	<915..1044	CDD:331207
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591129
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840