DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir40a and Grid2

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_077355.2	Gene:	Grid2 / 79220	RGDID:	68368	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	907	Identity:	154/907 - (16%)
Similarity:	286/907 - (31%)	Gaps:	328/907 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLNSTRLTFI-----GNDE-----------SDTAIALTQIVRGLQQSSLAILA----LPSLALSD 60
            :|.:.::||.     ||:.           :...:||...:......||..||    :|.|.:..
  Rat    57 ILQTEKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQR 121

  Fly    61 ----------GVCQKERN----------VYLDDFLQRLHRSNY---KSVVFSQTELFFQHIEENL 102
                      |:.:..||          |||::.:.|: .:.|   |.::|..:|...:.|:|.|
  Rat   122 STAGTPRSGCGLTRSNRNDDYTLSVRPPVYLNEVILRV-VTEYAWQKFIIFYDSEYDIRGIQEFL 185

  Fly   103 -----QGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPPSSRVIRFREPLR--VVV 160
                 ||.:..:..:.:..|:::.:|.|......|:                 |:|:.||  ::|
  Rat   186 DKVSQQGMDVALQKVENNINKMITTLFDTMRIEELN-----------------RYRDTLRRAILV 233

  Fly   161 VTRPRKKAF---------------RIYYNQARPCSDSQLQLVNWYDGDNL---GLQRIPLLPTAL 207
            :.....|:|               .|..|:.          :|..|...|   .:.|:.::....
  Rat   234 MNPATAKSFISEVVETNLVAFDCHWIIINEE----------INDVDVQELVRRSIGRLTIIRQTF 288

  Fly   208 SVYANFKGRTFR----------------------------------VPVFH-------------- 224
            .|..|...|.||                                  ...||
  Rat   289 PVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASL 353

  Fly   225 ------SPPW------------------------------------------------------F 229
                  |.||                                                      .
  Rat   354 SCIRKNSKPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGC 418

  Fly   230 W--VTYCNNSFEEDEEFNSLDSIEKRKVRVTG-----------GRDHR-------LLMLLSKHMN 274
            |  ||..|.|..:.:..|::..:..|.|.|..           |:..:       :|..||.::.
  Rat   419 WNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLG 483

  Fly   275 FRFKYIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFSFFTLA 339
            |.::...||....||.: |||     ::.|.:|.|...:||..:..:.::.:|...::|:...:.
  Rat   484 FNYEIYVAPDHKYGSPQ-EDG-----TWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMD 542

  Fly   340 DSGAFATHAPRRLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGIIALPYIWRRRWANSDVEHLG 404
            .|.........:..:..|.:.||...:|..:..|::..|.:.|.:         .|.|
  Rat   543 YSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLL---------NWLN------- 591

  Fly   405 ELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTI 469
                               .||  |....|........:||....|::|.....:.....:.:..
  Rat   592 -------------------PPR--LQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMG 635

  Fly   470 VYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQA------AMIHDGYRLYVEKESSSLEM 528
            .:|:.|..|::. |:|.|.:.......|..|.:||.|..      ..:.|. .:|.......|..
  Rat   636 AWWLFALIVISS-YTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDS-AVYQHVRMKGLNP 698

  Fly   529 LENGTELFRQLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGE----DKAVLGGRETLFFNVQQY 589
            .|..: ::.|::.::.:.  |..:...::| :|||:.:..|..    |.|||           :|
  Rat   699 FERDS-MYSQMWRMINRS--NGSENNVLES-QAGIQKVKYGNYAFVWDAAVL-----------EY 748

  Fly   590 GSNN------FQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQ----- 643
            .:.|      :.:...:..|...:|:|.|.|:....:..:::|.:||.:|.:....:.|.
  Rat   749 VAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNGQCDL 813

  Fly   644 YQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLAAGVILLLE 705
            |..|:|.:  ||..                     |:::.|.|.|..|..|.:.:.:|.:||
  Rat   814 YSSVDAKQ--KGGA---------------------LDIKSLAGVFCILAAGIVLSCLIAVLE 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	36/249 (14%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	15/93 (16%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	31/156 (20%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		53/315 (17%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:415822	60/399 (15%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	77/425 (18%)
		Interaction with AP4M1. /evidence=ECO:0000269\|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349990
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930