DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir40a and grin2ab

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_009304490.1	Gene:	grin2ab / 570493	ZFINID:	ZDB-GENE-070424-223	Length:	1445	Species:	Danio rerio

Alignment Length:	885	Identity:	161/885 - (18%)
Similarity:	276/885 - (31%)	Gaps:	331/885 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLGLLNSTRLTFIGNDESDTAIALTQIVRGLQQSSLAILA------------------------- 52
            :||:...:.:|..   |.|::.:..|....|||.:|.:||
Zfish   113 ILGIHGGSAMTMA---EKDSSSSFFQFGASLQQEALLMLAIMEEYDWHVFSVVTTKFPGFQEFIA 174

  Fly    53 --------------LPSLALSDGVCQKERNVYLDDFLQRLHRSNYKSVVFSQTELFFQHIEENLQ 103
                          |.|:...|||.:.|...::.  |:|:.         |...|.:...:|
Zfish   175 TVRVTVDHSFVRWDLQSVVTLDGVGEPEDRAHVQ--LKRIQ---------SPVILLYCSKDE--- 225

  Fly   104 GANECISLILDEPNQL----------LNSLHDRHLGH--------RLSLFIFYWGARWPPSSRV- 149
                 .:|:::|...|          :.||...:|.|        .:|:....|.  :|..:|:
Zfish   226 -----AALVMEEARSLGLTGAGFVWIVPSLTTGNLEHIPEAFPAGMISVTYDEWD--YPLETRLQ 283

  Fly   150 -----------IRFREPLRVVVVTRPRKKAFRIYYNQARPCSDSQLQLVNWYDGDNLGLQRIPLL 203
                       ..|||..|:...|..       .|.|:.........|..:..|.|||.:....:
Zfish   284 DAVGIISSAAAAMFREEGRIPDGTAS-------CYGQSEKPEVPPSALRRYMMGVNLGGKDHSFM 341

  Fly   204 -------PTALSVYANFK------GR------TFRVPVFHSPPWFWVTYCNNSF---EEDEEFNS 246
                   |..:.:..|.:      ||      ..:.||       |..|  |||   :.||...|
Zfish   342 DDGYQVNPKLVVIVLNTEREWEKMGRWENHSLRLKFPV-------WPRY--NSFGDMDADENHLS 397

  Fly   247 LDSIEKRKVRV-------TGG--------RDH--------------------RLLMLLSKHMNFR 276
            :.::|:|...:       ||.        |.|                    .:|..:::::.|.
Zfish   398 IVTLEERPFVIVDDVDILTGTCMRNSVPCRKHIKDNTTEGSYVKKCCKGFCIDILKKIARNVKFT 462

  Fly   277 FK-YIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFSF----- 335
            :. |:...|:        .||..|:.:.|.:|.:...:|...:|.:.::.||.:||:||.
Zfish   463 YDLYLVTNGK--------HGKKINNVWNGMVGEVVYKKAVMAVGSLTINEERSEAIDFSVPFVET 519

  Fly   336 -FTLADSGAFATHAPRRLNEALAIMRPFKQDIW--PHLILTIIFSGPIFYGIIALPYIWRRRWAN 397
             .::..|.:..|.:|.      |.:.||...:|  ..::|.|:.:..:|......|..:.|..|.
Zfish   520 GISVMVSRSNGTVSPS------AFLEPFSASVWVMMFVMLLIVTAIAVFLFEFISPLGFNRNLAQ 578

  Fly   398 SDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHN-- 460
            ....|                               .|.....|.:|....|....|. .:.|
Zfish   579 GKDPH-------------------------------GPSFTIGKAVWLLWGLVFNNSV-PVQNPR 611

  Fly   461 GYRAKFLTIVYWIAATYVLADVYSAQLTS-----------------QFARP-AREPPINTLQRLQ 507
            |..:||:..|:...|...||. |:|.|.:                 :|..| :..||..
Zfish   612 GTTSKFIVSVWAFFAVIFLAS-YTANLAAFMIQEEFVDQVTGLSDRKFQSPYSYSPPFR------ 669

  Fly   508 AAMIHDGYRLYVEKESSSLEMLENG-TEL-FRQLYALMRQQVINDPQGFFIDSV----------- 559
                              ...:.|| ||. .|:.|..|.|.::...|...:|::
Zfish   670 ------------------FGTVPNGSTERNIRKNYPAMHQYMVKYHQTGVVDALVSLKTGKLDAF 716

  Fly   560 --EAGIKLIAEGGED--KAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLN 620
              :|.:.....|.:|  |.|..|...:|... .||                :|:|.|..:...::
Zfish   717 IYDAAVLNYMAGRDDGCKLVTIGSGYIFATT-GYG----------------IAMQKGSYWKRLVD 764

  Fly   621 NVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQ 685
            ..::.:...|            :.:|:||..: .|....:.:|..|          |.|::..:.
Zfish   765 LAILGIIGDG------------EMEELEAQWL-TGICHNEKNEVMS----------SQLDVDNMA 806

  Fly   686 GAFIALGVGSLAAGVILLLEIVFIKLDQARLWM----LCS 721
            |.|..|.    ||..:.|:..|:..|...||..    |||
Zfish   807 GVFYMLA----AAMALSLITFVWEHLFYWRLRYCFTGLCS 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	34/172 (20%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	22/101 (22%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	25/157 (16%)
grin2ab	XP_009304490.1	PBP1_iGluR_NMDA_NR2	25..382	CDD:107373	53/306 (17%)
		ANF_receptor	48..358	CDD:279440	47/275 (17%)
		PBP2_iGluR_NMDA_Nr2	393..790	CDD:270436	86/497 (17%)
		Lig_chan	544..816	CDD:278489	63/372 (17%)
		NMDAR2_C	827..1445	CDD:287527	6/16 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591448
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930