DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir40a and grik4

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	699	Identity:	135/699 - (19%)
Similarity:	247/699 - (35%)	Gaps:	172/699 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 LDDFL-QRLHRSNYKSVVFSQTELFFQHI--------EEN-----LQGANECISLILDEPNQLLN 121
            |||.. ||::...:.  ||::|..|||..        :||     ..|.....:|:.|..:.::.
Zfish   255 LDDLADQRVNIVGFS--VFNRTHPFFQDFVLSLNRSWQENCDHAPFAGTPLSSALLFDAVHTVVA 317

  Fly   122 SLHDRHLGHRLSLFIFYWGAR---------WPPSSRVIRFREPLRVVVVT------------RPR 165
            ::.:.:....:       ||.         |...:.::.:   ||:|.:.            :..
Zfish   318 AVQELNRSQNV-------GATQLSCKSSKIWEHGTSLMNY---LRMVELEGLTGHIEFNSKGQRS 372

  Fly   166 KKAFRIYYNQARPCSDSQLQLVNWYDGDNLGLQRIPLLPTALSVYANFKGRTFRVPVFHSPPWFW 230
            ..|.||..|.    .|...|:..|:....|.::|  .|| :|:|.......|..:......|:..
Zfish   373 NYALRIMQNS----RDGLRQIGQWHSEQGLSMER--KLP-SLNVTDTLFNTTLTITTILENPYVM 430

  Fly   231 VTYCNNSFEEDEEFNS--LDSIEKRKVRVTGGRDHRLLMLLSKHMNFRFKYIEAPGRTQGSMRSE 293
            :...:...|.::.:..  :|.:::                |:..:.|:::.     |..|
Zfish   431 LRANHQELEGNDRYEGFCVDMLKE----------------LADILKFKYRI-----RLVG----- 469

  Fly   294 DG----KDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRL 352
            ||    ..:|.::||.:|.|.|.:||..:..:.::.||.|.|:||  |.||..|..:..|..||.
Zfish   470 DGVYGVPGANGTWTGMVGELISRKADLAVAALTITAEREKVIDFSKPFMTLGISIMYRVHIGRRP 534

  Fly   353 NEALAIMRPFKQDIWPHLILTIIFSGPIFYGIIAL-PYIWRRRWANSDVEHLGELYIHMTYLKEI 416
            . ..:.:.||...:|..::|..:....:.:.:..| ||.|                        .
Zfish   535 G-YFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEW------------------------Y 574

  Fly   417 TPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLAD 481
            .|... ||.|..|..:|..   .....||.:..|::|...........:.::.|:| |.|.::..
Zfish   575 NPHPC-LKGRCSLLINQYS---LGNSFWFPVGGFMQQGSTIAPRALSTRCVSGVWW-AFTLIIIS 634

  Fly   482 VYSAQLTSQFARPAREPPINTLQRL--QAAM----IHDGYRLYVEKESSSLEMLENGTELFRQLY 540
            .|:|.|.:.......|.||.::..|  |.|:    :|.|         |::...:|..   .|.|
Zfish   635 SYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTMHGG---------STMTFFQNSR---YQTY 687

  Fly   541 ALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYS 605
            ..|...:.:.....|:.|.|.||..:........:   ..|:....:|...|..|:...|.|:..
Zfish   688 QRMWNFMYSKQPSVFVKSTEEGIARVLNSNYAYLL---ESTMNEYYRQRNCNLTQIGGLLDTKGY 749

  Fly   606 AVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTES 670
            .:.:.:|..:....:..:::|.|...|             |:...:.:.|....|..:..::
Zfish   750 GIGMPLGSVYRDEFDLAILRLQEENRL-------------EILKRKWWDGGKCPKEEDHRAK--- 798

  Fly   671 YDSTVISPLNLRMLQGAFIALGVGSLAAGVILLLEIVFIKLDQARLWML 719
                   .|.:..:.|.|:.|..|.|.|..:.:||.|         |||
Zfish   799 -------GLGMENIGGIFVVLVCGLLVAIFMAVLEFV---------WML 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	25/129 (19%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	28/96 (29%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	28/146 (19%)
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	30/160 (19%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	84/443 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590971
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840