DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir40a and Grik2

DIOPT Version :9

Sequence 1:NP_610140.4 Gene:Ir40a / 35449 FlyBaseID:FBgn0259683 Length:732 Species:Drosophila melanogaster
Sequence 2:NP_062182.1 Gene:Grik2 / 54257 RGDID:2733 Length:908 Species:Rattus norvegicus


Alignment Length:758 Identity:142/758 - (18%)
Similarity:262/758 - (34%) Gaps:215/758 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ALGLLPYLLGLLNSTRLTFIGNDESDTAIALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVY 70
            ||.:.||....:|.|....:..:.       ||:...:::.|:..|..|         .|..:..
  Rat   263 ALDVEPYRYSGVNMTGFRILNTEN-------TQVSSIIEKWSMERLQAP---------PKPDSGL 311

  Fly    71 LDDFLQRLHRSNYKSVVFSQTELFFQHIEENLQGANECISLILDE-PNQLLNSLH-DRHLGHRLS 133
            ||.|:.......|.:|          |:          :|:.:.: |...::||. :||...|  
  Rat   312 LDGFMTTDAALMYDAV----------HV----------VSVAVQQFPQMTVSSLQCNRHKPWR-- 354

  Fly   134 LFIFYWGARWPPSSRVIRFREPLRVVVVTRPRKKAFRIYYNQARPC-SDSQLQLVNWYDGDNLGL 197
                 :|.|:            :.::..........||.:|:.... :|..|.:::..:.   ||
  Rat   355 -----FGTRF------------MSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEE---GL 399

  Fly   198 QRIPLLPTA--LSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTG- 259
            ::|.....|  |::..:.||:    |.                      |..||:..|.:.||. 
  Rat   400 EKIGTWDPASGLNMTESQKGK----PA----------------------NITDSLSNRSLIVTTI 438

  Fly   260 ----------------GRDH------RLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGK-----D 297
                            |.|.      .||..||..:.|.::.          ...||||     |
  Rat   439 LEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI----------RLVEDGKYGAQDD 493

  Fly   298 SNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEAL-AIM 359
            .|..:.|.:..|...:||..:..:.:::.|.|.|:||  |.||..|..:  ..|...|..: :.:
  Rat   494 VNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILY--RKPNGTNPGVFSFL 556

  Fly   360 RPFKQDIWPHLILTIIFSGPIFYGIIAL-PYIW-RRRWANSDVEHLGELYIHMTYLKEITPRLLK 422
            .|...|||.:::|..:....:.:.|... ||.| .....|.|.:.:...:               
  Rat   557 NPLSPDIWMYVLLACLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNF--------------- 606

  Fly   423 LKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQL 487
                |:|::           .||.:...::|....:......:.:..::|. .|.::...|:|.|
  Rat   607 ----TLLNS-----------FWFGVGALMRQGSELMPKALSTRIVGGIWWF-FTLIIISSYTANL 655

  Fly   488 TSQFARPAREPPINTLQ------RLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALM--- 543
            .:.......|.||::..      :::...:.||..:...|:|.        ...:.:::|.|   
  Rat   656 AAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSK--------ISTYDKMWAFMSSR 712

  Fly   544 RQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVA 608
            ||.|:       :.|.|.||:.:..  .|.|.|....|:.| |.|...|..|:...:.::...|.
  Rat   713 RQSVL-------VKSNEEGIQRVLT--SDYAFLMESTTIEF-VTQRNCNLTQIGGLIDSKGYGVG 767

  Fly   609 VQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDS 673
            ..:|.|:...:...::||.|.|.|..|....:..           .|..:.::.||         
  Rat   768 TPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRG-----------NGCPEEESKEA--------- 812

  Fly   674 TVISPLNLRMLQGAFIALGVGSLAAGVILLLEIVFIKLDQARL 716
               |.|.::.:.|.||.|..|.:.:..:.:.|.::.....|:|
  Rat   813 ---SALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQL 852

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir40aNP_610140.4 PBP2_LTTR_substrate 216..338 CDD:330233 30/151 (20%)
Periplasmic_Binding_Protein_Type_2 297..>391 CDD:328725 25/97 (26%)
Periplasmic_Binding_Protein_Type_2 <496..637 CDD:328725 34/149 (23%)
Grik2NP_062182.1 Periplasmic_Binding_Protein_Type_1 34..414 CDD:299141 37/208 (18%)
ANF_receptor 52..395 CDD:279440 32/186 (17%)
Periplasmic_Binding_Protein_Type_2 430..800 CDD:304360 86/430 (20%)
Glutamate binding. /evidence=ECO:0000269|PubMed:15721240, ECO:0000269|PubMed:17115050, ECO:0007744|PDB:1S50, ECO:0007744|PDB:1S7Y, ECO:0007744|PDB:2I0B, ECO:0007744|PDB:2I0C 516..518 0/1 (0%)
Lig_chan 562..831 CDD:278489 63/340 (19%)