DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir40a and grin2da

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_009292354.1	Gene:	grin2da / 449864	ZFINID:	ZDB-GENE-041008-124	Length:	1916	Species:	Danio rerio

Alignment Length:	620	Identity:	124/620 - (20%)
Similarity:	201/620 - (32%)	Gaps:	210/620 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 RWPPSSRVIRFREP------LRVV-------VVTRPRKKAFRIYYNQARPCSDSQLQLVNWYDGD 193
            |:||.||...|.:|      ||||       |:..|...........:.||
Zfish   435 RYPPWSRYGPFLKPLDDSQHLRVVTLEERPFVIVEPADPGTGSCIRDSVPC-------------- 485

  Fly   194 NLGLQRIPLLPTALSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVT 258
                 |:||                                |||.       .::.|:..| ...
Zfish   486 -----RLPL--------------------------------NNSM-------VVEGIQSMK-HCC 505

  Fly   259 GGRDHRLLMLLSKHMNFRFK-YIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVG 322
            .|....:|..|:|.:.|.:. |:...||        .||:.:..:.|.:|.:.|.:||..:|.:.
Zfish   506 KGFCIDVLKRLAKIVGFTYDLYLVTNGR--------HGKNIDGQWNGMVGEVVSKRADMAIGSLT 562

  Fly   323 LSWERRKAIEFSF------FTLADSGAFATHAPRRLNEALAIMRPFKQDIWPHLI---LTII--- 375
            ::.||.:.:|||.      .::..|.:..|.:|.      |.:.|:...:|..:.   |:::
Zfish   563 INEERSEVVEFSVPFVETGISVMVSRSNGTVSPS------AFLEPYSPAVWVMMFVMCLSVVAVT 621

  Fly   376 -----FSGPIFYGIIALPYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMP 435
                 |..|:.|.                                          |::.|.....
Zfish   622 VFIFEFFSPVGYN------------------------------------------RSLQSGKTAG 644

  Fly   436 HQLFQ--KCIWFTLRLFLKQSCN-ELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPARE 497
            ...|.  |.||....|....|.. |...|..:|.:.:|:...|...||. |:|.|.   |...:|
Zfish   645 GSKFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLAS-YTANLA---AFMIQE 705

  Fly   498 PPINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGT--ELFRQLYALMRQQVI-NDPQGFFIDSV 559
            ..|:|:..|...........|......:   :.||:  |..|..|..|.|.:: |:.:|     |
Zfish   706 EYIDTVSGLSDKKFQHPTEQYPPLRFGT---VPNGSTEENIRSNYPNMHQYMVRNNQRG-----V 762

  Fly   560 EAGIKLIAEGG-----EDKAVLG--GRETLFFNVQQYGSNNFQLSQKLY--TRYSAVAVQIGCPF 615
            |..|:.:..|.     .|.|||.  .|:.....|...||.      |::  |.| .||:.....:
Zfish   763 EDAIENLKTGKLDAFIYDAAVLNYMARKDEGCKVMTIGSG------KVFATTGY-GVALHKNSRW 820

  Fly   616 LGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLN 680
            ...|:..|:||.....:|.:              .|::...: ..|.:.        ..:.|.|:
Zfish   821 KRPLDLALLQLVGDDEIDML--------------ERLWLSGI-CHNDKI--------EVMSSKLD 862

  Fly   681 LRMLQGAFIALGVGSLAAGVILLL----EIVFIKL 711
            :..:.|.|..|.|   |.|:.||:    .:|:.||
Zfish   863 IDNMAGVFYMLLV---AMGLSLLVFAWEHLVYWKL 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	26/128 (20%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	21/110 (19%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	36/152 (24%)
grin2da	XP_009292354.1	PBP1_iGluR_NMDA_NR2	42..441	CDD:107373	3/5 (60%)
		PBP2_iGluR_NMDA_Nr2	452..851	CDD:270436	103/547 (19%)
		HisJ	<507..>590	CDD:223904	22/90 (24%)
		Lig_chan	605..877	CDD:278489	68/358 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591619
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930