DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir40a and GluRIID

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	151/762 - (19%)
Similarity:	266/762 - (34%)	Gaps:	217/762 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TRLTFIGNDESDTAIALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVYLDDFLQRLHRSNYK 84
            :|:..:|   |.|.:|  :::|..||..:               ..|...|:...| .||
  Fly   211 SRIVVVG---STTGVA--ELLRQAQQVGI---------------MNEDYTYIIGNL-NLH----- 249

  Fly    85 SVVFSQTELFFQHIEENLQGANECISLILDEPNQLLNSLHDRHLG-----HRLSLFIFYWGARWP 144
              .|...|  :::.|.|:.|. ...|...:|...|:..|| :.||     :..|.||....|...
  Fly   250 --TFDLEE--YKYSEANITGI-RMFSPDQEEVRDLMEKLH-QELGESEPVNSGSTFITMEMALTY 308

  Fly   145 PSSRVI----------------------------RFREPLRVVVVTRPRKKAF--RIYY--NQAR 177
            .:.|||                            .||..:|.:.:   ::|..  |||:  |..:
  Fly   309 DAVRVIAETTKHLPYQPQMLNCSERHDNVQPDGSTFRNYMRSLEI---KEKTITGRIYFEGNVRK 370

  Fly   178 PCSDSQLQLV--------NWYDGDNLGLQRIPLLPTALSVYANFK--------GRTFRVPV-FHS 225
            ..:...::|.        .|.:|.:...||.|..       .||.        .:||.|.: ..:
  Fly   371 GFTFDVIELQTSGLVKVGTWEEGKDFEFQRPPQA-------VNFNDIDDGSLVNKTFIVLISVAT 428

  Fly   226 PPWFWVTYC------NNSFEEDEEFNSLDSIEKRKVRVTGGRDHRLLMLLSKHMNFRFKYIEAPG 284
            .|:..:...      ||.|:                    |....|:..|:..:.|.|.:.:. |
  Fly   429 KPYASLVESIDTLIGNNQFQ--------------------GYGVDLIKELADKLGFNFTFRDG-G 472

  Fly   285 RTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATH 347
            ...||...     :.:|.:|.:..:..|:||..:.|:.::.||.:.|:||  |..|..:..:.
  Fly   473 NDYGSFNK-----TTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYV-- 530

  Fly   348 APRRLNEAL-AIMRPFKQDIWPHLILTIIFSGPIFYGIIALPYIWRR----RWAN--SDVEHLGE 405
            .|::...|| :.|.||..::|       ::.|..:.|:....:|..|    .|.|  ..:|...|
  Fly   531 KPQKAPPALFSFMDPFSSEVW-------LYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEE 588

  Fly   406 LYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIV 470
            |....|                           ....:|||....|:|...........:.::.:
  Fly   589 LENQFT---------------------------INNSLWFTTGALLQQGSEIAPKALSTRTISAI 626

  Fly   471 YWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGTEL 535
            :|. .|.::...|:|.|.:.........|||:::.|  |...|..:...::..|:........|
  Fly   627 WWF-FTLIMVSSYTANLAAFLTIENPTSPINSVKDL--ADNKDDVQYGAKRTGSTRNFFSTSEE- 687

  Fly   536 FRQLYALMRQQ--------VINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSN 592
              .:|..|.:.        :.|:.||  :|.|::|.|.        |.|....::.||..: ..|
  Fly   688 --PIYIKMNEYLNAHPEMLMENNQQG--VDKVKSGTKY--------AFLMESTSIEFNTVR-ECN 739

  Fly   593 NFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSV 657
            ..::...|..:...:|:....|:....|..|::|.|.|:|.::.    .|.:.||.|     |..
  Fly   740 LTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLK----NKWWNEVGA-----GVC 795

  Fly   658 QAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLAAGVILLL 704
            .||:          |....|.|.:..|.|.::.|.:||:.:.:|.:|
  Fly   796 SAKS----------DDDGPSELGVDNLSGIYVVLVIGSIISIIISIL 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	27/130 (21%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	22/96 (23%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	31/148 (21%)
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	43/220 (20%)
		ANF_receptor	46..380	CDD:279440	40/203 (20%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	87/453 (19%)
		Lig_chan	549..819	CDD:278489	64/339 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462831
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840