DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir40a and Grik

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	696	Identity:	141/696 - (20%)
Similarity:	260/696 - (37%)	Gaps:	163/696 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 LQRLHRSNYKSVVFSQTELFFQHIEENLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYW 139
            :|.:.::.|:|      |..||::...|..:   ::|:.|.. |||...: :|:..|........
  Fly   277 VQEVAKALYES------EEPFQNVSCPLTNS---MALVYDGV-QLLAETY-KHVNFRPVALSCND 330

  Fly   140 GARWPPSSRVIRFREPLRVVVVTRPRKKAFRIYYNQARPCSDSQLQLV-----------NWYDGD 193
            .:.|.....::.:.:.|.:..:|.|    .|..|...|  :|.:|:::           .|...|
  Fly   331 DSAWDKGYTLVNYMKSLTLNGLTGP----IRFDYEGLR--TDFKLEVIELAVSGMQKIGQWSGED 389

  Fly   194 NLGLQRIPLLPTALSVYANFK---GRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKV 255
              |.|.....| |.|:..:.:   .::|.|....|.|:..:...:...|.:::|... .||
  Fly   390 --GFQENRPAP-AHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKLEGNDQFEGF-GIE---- 446

  Fly   256 RVTGGRDHRLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGKDSNDSFTGGI--------GLLQ-- 310
                     |:..|||.:.|.:.:     |.|     ||.|      .|||        |:|:
  Fly   447 ---------LIDELSKKLGFSYTW-----RLQ-----EDNK------YGGIDPKTGEWNGMLREI 486

  Fly   311 -SGQADFFLGDVGLSWERRKAIEFSF-FTLADSGAFATHAPRRLNEALAIMRPFKQDIWPHLILT 373
             ..:||..:.|:.::.||...::|:. |.....|.......:...:..:.|.||..::|
  Fly   487 IDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVW------ 545

  Fly   374 IIFSGPIFYGIIALPYIWRR----RWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQM 434
             ::.|..:.|:....::..|    .|.|.           ...::|.|               ::
  Fly   546 -LWLGLAYMGVSISMFVLGRLSPAEWDNP-----------YPCIEEPT---------------EL 583

  Fly   435 PHQL-FQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREP 498
            .:|. |..|:||::...|:|........|..:.:...:|. .|.:|...|:|.|.:.....:...
  Fly   584 ENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWF-FTLILVSSYTANLAAFLTVESLVT 647

  Fly   499 PINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALMRQ--QVINDPQGFFIDSVE- 560
            |||....|........|...:...:.:. ..|:....::::|..||.  |.:.:.....:|.||
  Fly   648 PINDADDLSKNKGGVNYGAKIGGATFNF-FKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVEN 711

  Fly   561 AGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQ 625
            :....:.|....:.:...|.||    .|.|:   .|.:|.|    .:|::...|:..:|:..:::
  Fly   712 SNYAFLMESTTIEYITERRCTL----TQVGA---LLDEKGY----GIAMRKNWPYRDTLSQAVLE 765

  Fly   626 LFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIA 690
            :.|.|:|.||.    .|.:||            .:...|.|..:. ||..:: |.:..|.|.|:.
  Fly   766 MQEQGLLTKMK----TKWWQE------------KRGGGACSDADE-DSGAVA-LEISNLGGVFLV 812

  Fly   691 LGVGSLAAGVILLLEIVF-IK--------------LDQARLWMLCS 721
            :||||.....:.|||:|. :|              ||:.|..:.||
  Fly   813 MGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCS 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	30/133 (23%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	19/105 (18%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	30/143 (21%)
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	25/132 (19%)
		ANF_receptor	53..374	CDD:279440	23/113 (20%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	87/449 (19%)
		Lig_chan	543..816	CDD:278489	64/336 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462829
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840