DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir40a and gria4a

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_999971.1	Gene:	gria4a / 407735	ZFINID:	ZDB-GENE-020125-7	Length:	898	Species:	Danio rerio

Alignment Length:	822	Identity:	161/822 - (19%)
Similarity:	292/822 - (35%)	Gaps:	239/822 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LGLLPYLLGLLNS-------TRLTFIGNDESDTAIALTQIV------RGLQQSSLAILALPSLAL 58
            |.|.|.:.|.|.|       :|..|:  .::|...|:.|.:      .|.|.|::.:
Zfish   127 LQLRPSIRGALLSLLDHYDWSRFVFL--YDTDRGYAVLQAIMEKAGQNGWQVSAICV-------- 181

  Fly    59 SDGVCQKERNVYLDDFLQRLHRSNYKSVVFSQTELFFQHIE-ENLQGANECISLILDEPNQLLNS 122
                         ::|....:|...:.:...|.:.|...:| |.||...|.|..:    .:.:..
Zfish   182 -------------ENFNDASYRRLLEDLDRRQEKKFVIDLEAERLQNILEQIVSV----GKHVKG 229

  Fly   123 LH--DRHLGHR-LSLFIFYWGARWPPSSRVIRFREPLRVVVVTRPRKKAFRIYYNQARPCSDSQL 184
            .|  ..:||.: :||..|..|.......:::.|.:|:.:.::.|..|...|.|     |.|:|..
Zfish   230 YHYIVANLGFKDISLERFMHGGANVTGFQLVDFSKPMVIKLMQRWNKLDQREY-----PGSESPP 289

  Fly   185 QLVN--WYDG--------DNLGLQRI--------------PLLPTALSV-------YANFKGRTF 218
            :..:  .|||        .||..|:|              |..|....:       ....:|.|.
Zfish   290 RYTSSLTYDGVLVMAEAFRNLRRQKIDISRRGNAGDCLANPAAPWNQGIDMERTLKQVRIQGLTG 354

  Fly   219 RVPVFHSPPWFWVTYCNNSFEEDEE-------FNSLD---------------SIEKRKVRVTGGR 261
            .:...|...  .|.|..:.||....       :|.||               ::|.|.|.||...
Zfish   355 NIQFDHYGR--RVNYTMDVFELKSNGPRKIGYWNDLDKLVLVQNELSMGNDSAMENRTVIVTTIM 417

  Fly   262 DHRLLML-----------------------LSKHMNFRFKY-IEAPGRTQGSMRSEDGKDSNDSF 302
            :...:||                       ::||:..::|. |...|:.  ..|..:.|..|
Zfish   418 EGPYVMLKKNWEMYEGNEQFEGYCVDLASEVAKHIGIKYKISIVLDGKY--GARDPETKIWN--- 477

  Fly   303 TGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEAL-AIMRPFKQ 364
             |.:|.|..|:|:..:..:.::..|.:.|:||  |.:|..|  .....|::....: :.:.|...
Zfish   478 -GMVGELVYGKAEIAVAPLAITLVREEVIDFSKPFMSLGIS--IMIKKPQKSKPGVFSFLDPLAY 539

  Fly   365 DIWPHLILTIIFSGPIFYGIIALPYIWRR----RWANSDVEHLGELYIHMTYLKEITPRLLKLKP 425
            :||    :.|:|:   :.|:..:.::..|    .|...:.|...:                  .|
Zfish   540 EIW----MCIVFA---YIGVSVVLFLVSRFSPYEWHTEEPEEGSD------------------GP 579

  Fly   426 RTVLSAHQMPHQ--LFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLT 488
                .:.|.|::  :|.. :||:|..|::|.|:........:.:..|:|. .|.::...|:|.|.
Zfish   580 ----PSDQPPNEFGIFNS-LWFSLGAFMQQGCDFTPRSLSGRIVGGVWWF-FTLIIISSYTANLA 638

  Fly   489 SQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGT--ELFRQ----LYALMRQQV 547
            :.........||.:.:.|            .::...:...|::|:  |.||:    :|..|...:
Zfish   639 AFLTVERMVSPIESAEDL------------AKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYM 691

  Fly   548 INDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQY------------GSNNFQLSQKL 600
            .:.....|..:...|:..:.:.....|.|     |...:.:|            |.|   |..|.
Zfish   692 KSAEPTVFTKTTAEGVARVRKSKGKYAFL-----LESTMNEYTEQRKPCDTMKVGGN---LDSKG 748

  Fly   601 YTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAY 665
            |...:....|:|.|    :|..:::|.|:|:|||:....:   |.:.|......|| :.|:|:|
Zfish   749 YGVATPKGSQLGTP----VNLAVLKLSEAGVLDKLKNKWW---YDKGECGPKDSGS-KDKSSQA- 804

  Fly   666 SRTESYDSTVISPLNLRMLQGAFIALGVGSLAAGVILLLEIV 707
                         |:|..:.|.|..| ||.|  |:.:|:.:|
Zfish   805 -------------LSLSNVAGVFYIL-VGGL--GLAMLVALV 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	34/169 (20%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	20/96 (21%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	31/158 (20%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..393	CDD:107383	59/299 (20%)
		ANF_receptor	34..375	CDD:279440	56/281 (20%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	84/447 (19%)
		Lig_chan	540..821	CDD:278489	69/354 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591624
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840