DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir40a and gria1b

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	820	Identity:	163/820 - (19%)
Similarity:	274/820 - (33%)	Gaps:	273/820 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DTAIALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVYLDDFLQRLH---------RSNYKSV 86
            |||...|..|..:...:|...|... |:.|...:||..:.||..|:||:         :.|.|:.
Zfish   162 DTAAEKTWQVTSINFDTLTEAAFLK-AIQDLDNKKEFKIILDCELERLNSILNLIAAQKKNLKNY 225

  Fly    87 VFSQTELFFQHIEENLQ-----GANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPPS 146
            .:....|.|  ::.||.     |||.       ...||:|..:                   |..
Zfish   226 HYILANLGF--LDLNLTEFRKGGANV-------TGFQLMNYTN-------------------PTV 262

  Fly   147 SRVIR---------FREPLRVVVVTRPRKKAFRIYYNQARPCSDSQLQLVNWYDG--------DN 194
            ||.|:         .:.|.|            |:.|..|..           |||        .|
Zfish   263 SRTIQDWLEFDSKDLKSPKR------------RLKYTGALT-----------YDGVTVMATAFQN 304

  Fly   195 LGLQRIPL----------------------LPTALS----------VYANFKG-RT-FRVPVFHS 225
            |..|||.:                      :..||.          |..|.|| || |.|.|...
Zfish   305 LRKQRIDISRRGNAGECLANPPAPWGQGIDIQRALQQVQFEGLTGHVQFNDKGHRTNFTVSVMEF 369

  Fly   226 PP------WFW---------VTYCNNSFEEDEEFNSLDSIEKRKVRVTGGRDHRLLML------- 268
            .|      .:|         .||.|       ..|....::.|...||...:...:||
Zfish   370 GPSGPKKVGYWNQREKYVSTATYSN-------MLNETFGLQNRTYVVTTILEAPYVMLKKNHEQL 427

  Fly   269 ----------------LSKHMNFRFKYIEAPGRTQGSMRSEDGK-DSNDSFT----GGIGLLQSG 312
                            ::||:.:.:: :|..|         ||| .:.|:.|    |.:|.|..|
Zfish   428 VGNDKYEGYCVELAAEIAKHVGYSYR-LELVG---------DGKYGARDAETMMWNGMVGELVYG 482

  Fly   313 QADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEAL-AIMRPFKQDIWPHLILTI 374
            :||..:..:.::..|.:.|:||  |.:|..|  .....|.:....: :.:.|...:||    :.|
Zfish   483 KADVAVAPLTITLVREEVIDFSKPFMSLGIS--IMIKKPTKSKPGVFSFLDPLAYEIW----MCI 541

  Fly   375 IFSGPIFYGIIALPYIWRR----RWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMP 435
            :|:   :.|:..:.::..|    .|...|.|...:      ...:..|.    .|....|.:|..
Zfish   542 VFA---YIGVSVVLFLVSRFSPYEWHADDEEETAD------QQNQNQPP----SPEPNQSPNQSQ 593

  Fly   436 HQLFQK---------------CIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSA 485
            :|..:|               .:||:|..|::|.|:........:.:..|:|. .|.::...|:|
Zfish   594 NQREEKQEKQPEHTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWF-FTLIIISSYTA 657

  Fly   486 QLTSQFARPAREPPINTLQRL--QAAMIH---DGYRLYVEKESSSLEMLENG-TELFRQLYALMR 544
            .|.:.........||.:.:.|  |..:.:   ||        .|:.|..... ..:|.::::.|:
Zfish   658 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDG--------GSTKEFFRRSKIAVFEKMWSYMK 714

  Fly   545 QQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAV 609
            ..   :|. .|:.:.:.|:..:.:.....|.|.......:..|:...:..::...|.::...||.
Zfish   715 SA---EPT-VFVKTTDEGVVRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVAT 775

  Fly   610 QIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTE----- 669
            ..|......:|..:::|.|.|:|||:                        ||...|.:.|
Zfish   776 PKGSALRNPVNLAVLKLNEQGLLDKL------------------------KNKWWYDKGECGSGG 816

  Fly   670 --SYDSTVISPLNLRMLQGAFIALGVGSLAAGVILLLEIV 707
              |.|.|  |.|:|..:.|.|..| :|.|  |:.:|:.:|
Zfish   817 GDSKDKT--SALSLSNVAGVFYIL-IGGL--GLAMLVALV 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	36/167 (22%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	22/100 (22%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	27/146 (18%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385	58/276 (21%)
		ANF_receptor	41..368	CDD:279440	56/257 (22%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	86/473 (18%)
		Lig_chan	536..842	CDD:278489	68/362 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591480
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840