DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir40a and GluRIA

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster

Alignment Length:	445	Identity:	91/445 - (20%)
Similarity:	167/445 - (37%)	Gaps:	120/445 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 GGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADS-----------GAFATHAPRRLNEA 355
            |.:|.|...:||..:..:.::.||.:.|:||  |.||..|           |.|
  Fly   550 GMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVF----------- 603

  Fly   356 LAIMRPFKQDIWPHLILTIIFSGPIFYGIIAL-PYIW---RRRWANSDVEH---------LGELY 407
             :.:.|..|:||..:||:.:....:.|.:... ||.|   ||..|:|..:.         |.|..
  Fly   604 -SFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQ 667

  Fly   408 IHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYW 472
            .|   :..:.|...     |:|::           .|::|..|::|.|:........:....|:|
  Fly   668 AH---VPPVPPNEF-----TMLNS-----------FWYSLAAFMQQGCDITPPSIAGRIAAAVWW 713

  Fly   473 IAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEM---LENGTE 534
            . .|.:|...|:|.|.:          ..|::|:.|.:          |....|.|   :..||.
  Fly   714 F-FTIILISSYTANLAA----------FLTVERMVAPI----------KTPEDLTMQTDVNYGTL 757

  Fly   535 LFRQLYALMRQ----------QVINDPQGFFIDSVEAGIKLIAEG-GEDKAVLGGRETLFFNVQQ 588
            |:...:...|:          :.:|..|...:.:.:.||:.:.:. |:...::...:..:.|.:.
  Fly   758 LYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARP 822

  Fly   589 YGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIY 653
             ..:..::.:.:.|:...||..||.|....||..::.|.|:|                 |..||
  Fly   823 -PCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENG-----------------ELLRI- 868

  Fly   654 KGSVQAKNSEAYSRTE-SYDSTVISP--LNLRMLQGAFIALGVGSLAAGVILLLE 705
                  :|...:.:|| :.|....:|  |:|..:.|.:..|..|.|.|.::.::|
  Fly   869 ------RNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIME 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	11/35 (31%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	25/100 (25%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	27/154 (18%)
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375
		ANF_receptor	53..434	CDD:279440
		PBP2_iGluR_AMPA	477..879	CDD:270433	80/405 (20%)
		Lig_chan	612..907	CDD:278489	69/359 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462543
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840