Protein Alignment Ir40a and gria4b

DIOPT Version :10

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_997917.2
• Gene: gria4b / 336069
• ZFINID: ZDB-GENE-030131-8013
• Length: 904
• Species: Danio rerio
• Alignment Length: 820
• Identity: 162/820 - (19%)
• Similarity: 289/820 - (35%)
• Gaps: 215/820 - (26%)

  Fly     7 LGLLPYLLGLLNS-------TRLTFIGNDESDTAIALTQIV------RGLQQSSLAILALPSLA- 57
            |.|.|.:.|.|.|       .|..|:  .::|...::.|.:      .|.|.|::.:......:
Zfish   132 LQLRPSIRGALLSLLDHYDWNRFVFL--YDTDRGYSILQAIMEKAGQNGWQVSAICVENFNDASY 194

  Fly    58 ---LSDGVCQKERNVYLDDFLQRLHR---------SNYKSVVFSQTELFFQHIEENLQ-----GA 105
               |.|...::|:...:|...:||:.         .:.|...:....|.|:.|  ||:     ||
Zfish   195 RQLLEDLDRRQEKTFVIDLEAERLNNMLEQIVSVGKHVKGYHYIMANLGFKDI--NLERFMHGGA 257

  Fly   106 NECISLILDEPNQLL-------NSLHDRHLGHRLSLFIFYWGARWPP--SSRVI---------RF 152
            |.....::|..|.::       |.|..|.          |.|:..||  :|.:.         .|
Zfish   258 NVTGFQLVDFSNPMVIKLMQRWNKLDQRE----------YPGSDAPPKYTSALTYDGVMVMAEAF 312

  Fly   153 REPLRVVVVTRPRKKAFRIYYNQARPCSD--------SQLQL---------------VN------ 188
            |...|..|....|..|.....|.|.|.:.        .|:.|               ||
Zfish   313 RNLRRQKVDISRRGIAGDCLANPAAPWNQGIDMERTLKQVHLQGLTGNVQFDHYGRRVNYTMDVF 377

  Fly   189 ------------WYDGDNLGL-QRIPLLPTALSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEE 240
                        |.|.|.|.| |...|||...|   ..:.||..|......|:..:......:|.
Zfish   378 ELKSNGPRRIGYWNDADKLVLTQDHALLPNETS---GMENRTVIVTTIMEGPYVMLKKNWEMYEG 439

  Fly   241 DEEFNSLDSIEKRKVRVTGGRDHRLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGKDSNDSFTGG 305
            :|::.              |....|...::||:.|::|....|....|: |..:.|..|    |.
Zfish   440 NEQYE--------------GYCVDLASEIAKHIGFKYKISIVPDGKYGA-RDPETKIWN----GM 485

  Fly   306 IGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEAL-AIMRPFKQDIW 367
            :|.|..|:|:..:..:.::..|.:.|:||  |.:|..|  .....|::....: :.:.|...:||
Zfish   486 VGELVYGKAEIAVAPLTITLVREEVIDFSKPFMSLGIS--IMIKKPQKSKPGVFSFLDPLAYEIW 548

  Fly   368 PHLILTIIFSGPIFYGIIAL--------PYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLK 424
                :.|:|:   :.|:..:        ||.|                 |....:|.|..
Zfish   549 ----MCIVFA---YIGVSVVLFLVSRFSPYEW-----------------HTEEPEEGTDG----- 584

  Fly   425 PRTVLSAHQMPHQ--LFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQL 487
                |.:.|.|::  :|.. :||:|..|::|.|:........:.:..|:|. .|.::...|:|.|
Zfish   585 ----LPSDQPPNEFGIFNS-LWFSLGAFMQQGCDISPRSLSGRIVGGVWWF-FTLIIISSYTANL 643

  Fly   488 TSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGT--ELFRQ----LYALMRQQ 546
            .:.........||.:.:.|            .::...:...|::|:  |.||:    :|..|...
Zfish   644 AAFLTVERMVSPIESAEDL------------AKQTDIAYGTLDSGSTKEFFRRSKIAVYEKMWSY 696

  Fly   547 VINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQI 611
            :.:.....|..:...|:..:.:.....|.|.......:..|:...:..::...|.::...||...
Zfish   697 MKSAEPTVFTKTTAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPK 761

  Fly   612 GCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVI 676
            |.....::|..:::|.|.|:|||:.    .|.:.:........|..:.|:|:|
Zfish   762 GSQLRSAVNLAVLKLNEQGLLDKLK----NKWWYDKGECGSGGGGEKDKSSQA------------ 810

  Fly   677 SPLNLRMLQGAFIALGVGSLA-AGVILLLEIVFIKLDQAR 715
              |:|..:.|.|..| ||.|. |.::.|:|..:...::|:
Zfish   811 --LSLSNVAGVFYIL-VGGLGLAMLVALIEFCYKSRNEAK 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	19/72 (26%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	22/104 (21%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	26/146 (18%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_type1	28..400	CDD:471960	56/281 (20%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	85/450 (19%)
		Lig_chan	546..826	CDD:459656	64/345 (19%)