DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir40a and Nmdar2

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster

Alignment Length:	471	Identity:	98/471 - (20%)
Similarity:	171/471 - (36%)	Gaps:	119/471 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 KYIEAPGRTQGSMRSEDGK---DSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFSFFTLA 339
            |:.|..|.|...:|.||||   ..|..:.|.|..|.:.:.|..|..:.::.||...::|| ....
  Fly   573 KFAEELGFTYELVRVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFS-EPFM 636

  Fly   340 DSGAFATHAPRR-LNEALAIMRPFKQDIWPHLILTIIFSGPIFYGIIALP----YIWRRRWANSD 399
            ::|.....|.|. :....|.:.||....|            :..||:|:.    .|:...|.:..
  Fly   637 ETGIAIVVAKRTGIISPTAFLEPFDTASW------------MLVGIVAIQAATFMIFLFEWLSPS 689

  Fly   400 VEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCN-ELHNGYR 463
            ...: :||:..|   .:||....|                .:..|....:..:.:.: :...|:.
  Fly   690 GYDM-KLYLQNT---NVTPYRFSL----------------FRTYWLVWAVLFQAAVHVDSPRGFT 734

  Fly   464 AKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEM 528
            ::|:|.|:.:.|...|| :|:|.|.:...........:.|.  .:.::|.    :..|.|
  Fly   735 SRFMTNVWALFAVVFLA-IYTANLAAFMITREEFHEFSGLN--DSRLVHP----FSHKPS----- 787

  Fly   529 LENGT-----------ELFRQLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETL 582
            .:.||           :.|..::..|||        :...||..|:..:..|..|..:..| ..|
  Fly   788 FKFGTIPYSHTDSTIHKYFNVMHNYMRQ--------YNKTSVADGVAAVLNGNLDSFIYDG-TVL 843

  Fly   583 FFNVQQ------------YGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKM 635
            .:.|.|            |....:.|:....::|    ||:       .|..|::...:|.|:::
  Fly   844 DYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKY----VQM-------FNKRLLEFRANGDLERL 897

  Fly   636 TAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLAAGV 700
                  ::|......|  .|..:.|:|:              ||.|.....||:.|..|.|.|.:
  Fly   898 ------RRYWMTGTCR--PGKQEHKSSD--------------PLALEQFLSAFLLLMAGILLAAL 940

  Fly   701 ILLLEIVFIKLDQARL 716
            :||||.|:.|..:.||
  Fly   941 LLLLEHVYFKYIRKRL 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	19/62 (31%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	20/98 (20%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	28/163 (17%)
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	78/407 (19%)
		Lig_chan	665..928	CDD:278489	59/348 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463001
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840