DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir40a and Grik3

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	782	Identity:	148/782 - (18%)
Similarity:	265/782 - (33%)	Gaps:	238/782 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ALGLLPYLLGLLNSTRLTFIGNDESDTAIALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVY 70
            ||.|.||....:|.|....:..|...    ::.||.......|.........|.|||...:..:.
  Rat   266 ALDLEPYRYSGVNLTGFRILNVDNPH----VSAIVEKWSMERLQAAPRAESGLLDGVMMTDAALL 326

  Fly    71 LDDFLQRLHRSNYKSVVFSQTELFFQHIEENLQGANECISLILDEPNQLLNSLH-DRH----LGH 130
            .|    .:|   ..||.:.:.                        |...:|||. .||    .|.
  Rat   327 YD----AVH---IVSVCYQRA------------------------PQMTVNSLQCHRHKAWRFGG 360

  Fly   131 RLSLFIFYWGARWPPSSRVIRFREPLRVVVVTRPRKKAFRIYYNQARPC-SDSQLQLVNWYDGDN 194
            |...||  ..|:|          |.|           ..||.:|:.... :|..|.:::..:.
  Rat   361 RFMNFI--KEAQW----------EGL-----------TGRIVFNKTSGLRTDFDLDIISLKED-- 400

  Fly   195 LGLQRIPLLPTA--LSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRV 257
             ||:::.:...|  |::....|||        .|                  |..||:..|.:.|
  Rat   401 -GLEKVGVWSPADGLNITEVAKGR--------GP------------------NVTDSLTNRSLIV 438

  Fly   258 TG-----------------GRDH------RLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGK--- 296
            |.                 |.|.      .||..|:..:.|.::.          ...||||
  Rat   439 TTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEI----------RLVEDGKYGA 493

  Fly   297 -DSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEAL-A 357
             |....:.|.:..|...:||..:..:.::..|.|||:||  |.||..|..:  ..|...|.:: :
  Rat   494 QDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILY--RKPNGTNPSVFS 556

  Fly   358 IMRPFKQDIWPHLILTIIFSGPIFYGIIAL-PYIWRRRWANSDVEHLGELYIHMTYLKEITPRLL 421
            .:.|...|||.:::|..:....:.:.|... ||    .|.::...:.|...:...:
  Rat   557 FLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPY----EWYDAHPCNPGSEVVENNF--------- 608

  Fly   422 KLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQ 486
                 |:|::           .||.:...::|....:......:.:..::|. .|.::...|:|.
  Rat   609 -----TLLNS-----------FWFGMGSLMQQGSELMPKALSTRIIGGIWWF-FTLIIISSYTAN 656

  Fly   487 LTSQFARPAREPPINTLQ------RLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALMRQ 545
            |.:.......|.||::..      :::...:.||..:...|:|.        ...|.:::|.|..
  Rat   657 LAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSK--------ISTFEKMWAFMSS 713

  Fly   546 QVINDPQGFFIDSVEAGIK--LIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVA 608
            :    |.. .:.:.|.||:  |.|    |.|:|....|:.: :.|...|..|:...:.::...:.
  Rat   714 K----PSA-LVKNNEEGIQRTLTA----DYALLMESTTIEY-ITQRNCNLTQIGGLIDSKGYGIG 768

  Fly   609 VQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGS--VQAKNSEAYSRTESY 671
            ..:|.|:...:...::||.|.   ||:          .:...:.::||  .:.:|.||
  Rat   769 TPMGSPYRDKITIAILQLQEE---DKL----------HIMKEKWWRGSGCPEEENKEA------- 813

  Fly   672 DSTVISPLNLRMLQGAFIALGVGSLAAGVILLLEIVFIKL----------------DQARLWMLC 720
                 |.|.::.:.|.||.|..|.:.:.::.:.|.:: ||                |:.|..:.|
  Rat   814 -----SALGIQKIGGIFIVLAAGLVLSVLVAVGEFIY-KLRKTAEREQRSFCSTVADEIRFSLTC 872

  Fly   721 SR 722
            .|
  Rat   873 QR 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	30/150 (20%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	25/97 (26%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	30/148 (20%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	42/211 (20%)
		ANF_receptor	55..398	CDD:279440	38/189 (20%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	80/440 (18%)
		Lig_chan	564..832	CDD:278489	60/340 (18%)
		Glutamate binding	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350091
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840