Protein Alignment Ir40a and Gria4

DIOPT Version :9

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001106655.1
• Gene: Gria4 / 29629
• RGDID: 61863
• Length: 902
• Species: Rattus norvegicus
• Alignment Length: 585
• Identity: 124/585 - (21%)
• Similarity: 213/585 - (36%)
• Gaps: 152/585 - (25%)

  Fly   162 TRPRKKAFRIYYNQARPCSDSQLQLVNWYDGDNLGLQRIPLLPTALSVYANFKGRTFRVPVFHSP 226
            |.|||..:                   |.|.|.|.|  |..:||..:..|..:.||..|......
  Rat   382 TGPRKVGY-------------------WNDMDKLVL--IQDMPTLGNDTAAIENRTVVVTTIMES 425

  Fly   227 PWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTGGRDHRLLMLLSKHMNFRFKYIEAPGRTQGSMR 291
            |  :|.|..|    .|.|...|..|        |....|...::||:..::|....|....|: |
  Rat   426 P--YVMYKKN----HEMFEGNDKYE--------GYCVDLASEIAKHIGIKYKIAIVPDGKYGA-R 475

  Fly   292 SEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNE 354
            ..|.|..|    |.:|.|..|:|:..:..:.::..|.:.|:||  |.:|..|  .....|::...
  Rat   476 DADTKIWN----GMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGIS--IMIKKPQKSKP 534

  Fly   355 AL-AIMRPFKQDIWPHLILTIIFSGPIFYGIIAL--------PYIWRRRWANSDVEHLGELYIHM 410
            .: :.:.|...:||    :.|:|:   :.|:..:        ||.|          |..|
  Rat   535 GVFSFLDPLAYEIW----MCIVFA---YIGVSVVLFLVSRFSPYEW----------HTEE----- 577

  Fly   411 TYLKEITPRLLKLKPRTVLSAHQMPHQ--LFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWI 473
                   |...|..|     :.|.|::  :|.. :||:|..|::|.|:........:.:..|:|.
  Rat   578 -------PEDGKEGP-----SDQPPNEFGIFNS-LWFSLGAFMQQGCDISPRSLSGRIVGGVWWF 629

  Fly   474 AATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGT--ELF 536
             .|.::...|:|.|.:.........||.:.:.|            .::...:...|::|:  |.|
  Rat   630 -FTLIIISSYTANLAAFLTVERMVSPIESAEDL------------AKQTEIAYGTLDSGSTKEFF 681

  Fly   537 R--------QLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNN 593
            |        :::..||..   :|..|...:.|...::....|:...:|......:.. |:...:.
  Rat   682 RRSKIAVYEKMWTYMRSA---EPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIE-QRKPCDT 742

  Fly   594 FQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQ 658
            .::...|.::...||...|.....::|..:::|.|.|:|||:
  Rat   743 MKVGGNLDSKGYGVATPKGSSLRNAVNLAVLKLNEQGLLDKL----------------------- 784

  Fly   659 AKNSEAYSRTE-------SYDSTVISPLNLRMLQGAFIALGVGSLA-AGVILLLEIVFIKLDQAR 715
             ||...|.:.|       |.|.|  |.|:|..:.|.|..| ||.|. |.::.|:|..:....:|:
  Rat   785 -KNKWWYDKGECGSGGGDSKDKT--SALSLSNVAGVFYIL-VGGLGLAMLVALIEFCYKSRAEAK 845

  Fly   716  715
              Rat   846  845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	32/123 (26%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	22/104 (21%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	27/150 (18%)
Gria4	NP_001106655.1	PBP1_iGluR_AMPA_GluR4	28..398	CDD:107383	8/34 (24%)
		ANF_receptor	39..380	CDD:279440
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	94/477 (20%)
		Lig_chan	546..825	CDD:278489	70/357 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350089
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840