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Protein Alignment Ir40a and GRIN2B

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_000825.2	Gene:	GRIN2B / 2904	HGNCID:	4586	Length:	1484	Species:	Homo sapiens

Alignment Length:	810	Identity:	140/810 - (17%)
Similarity:	253/810 - (31%)	Gaps:	306/810 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DESDTAIALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVYLDDFLQRLHRSNY------KSV 86
            |:.|:.|          |:.|..|..|.:.|   .|.||...|:.:....:..:.|      .|:
Human   210 DDGDSKI----------QNQLKKLQSPIILL---YCTKEEATYIFEVANSVGLTGYGYTWIVPSL 261

  Fly    87 VFSQTELFFQHIEENLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPPSSRVIR 151
            |...|:                 ::..:.|..|::..:|.            |....|     .|
Human   262 VAGDTD-----------------TVPAEFPTGLISVSYDE------------WDYGLP-----AR 292

  Fly   152 FREPLRVVV------------VTRPRKKAF-----RIYYNQARPCSDSQLQLVNWY------DGD 193
            .|:.:.::.            :..|:...:     |||          |..::|.|      :|.
Human   293 VRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIY----------QSNMLNRYLINVTFEGR 347

  Fly   194 NL-----GLQRIPLLPTAL-------SVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNS 246
            ||     |.|..|.|...|       .....:|.::.::..:     .|...|..:.|::::..|
Human   348 NLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYY-----VWPRMCPETEEQEDDHLS 407

  Fly   247 LDSIEK-----------------------RKVRVTGGRDHR---------------LLMLLSKHM 273
            :.::|:                       :|..||..:...               :|..:||.:
Human   408 IVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSV 472

  Fly   274 NFRFK-YIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFSF-- 335
            .|.:. |:...|:        .||..|.::.|.||.:...:|...:|.:.::.||.:.::||.
Human   473 KFTYDLYLVTNGK--------HGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPF 529

  Fly   336 ----FTLADSGAFATHAPRRLNEALAIMRPFKQDIW--PHLILTIIFSGPIFYGIIALPYIWRRR 394
                .::..|.:..|.:|.      |.:.||..|:|  ..::|.|:.:..:|......|..:.|.
Human   530 IETGISVMVSRSNGTVSPS------AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRC 588

  Fly   395 WANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELH 459
            .|  |....|.                             |.....|.||....|....|. .:.
Human   589 LA--DGREPGG-----------------------------PSFTIGKAIWLLWGLVFNNSV-PVQ 621

  Fly   460 N--GYRAKFLTIVYWIAATYVLADVYSAQLTS-----------------QFARPAR-EPPINTLQ 504
            |  |..:|.:..|:...|...||. |:|.|.:                 :|.||.. .||
Human   622 NPKGTTSKIMVSVWAFFAVIFLAS-YTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPP----- 680

  Fly   505 RLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALM---RQQVINDP---------QGFFID 557
                      :|.......|:...:.|.   :.:::|.|   .|:.::|.         ..|..|
Human   681 ----------FRFGTVPNGSTERNIRNN---YAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYD 732

  Fly   558 SV--------EAGIKLIAEG-GEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGC 613
            :.        :.|.||:..| |:..|..|           ||                :|:|...
Human   733 AAVLNYMAGRDEGCKLVTIGSGKVFASTG-----------YG----------------IAIQKDS 770

  Fly   614 PFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISP 678
            .:...::..::|||..|            :.:|:||..: .|....:.:|..|          |.
Human   771 GWKRQVDLAILQLFGDG------------EMEELEALWL-TGICHNEKNEVMS----------SQ 812

  Fly   679 LNLRMLQGAFIALGVGSLAAGVILLLEIVF 708
            |::..:.|.|..||.....:.:..:.|.:|
Human   813 LDIDNMAGVFYMLGAAMALSLITFICEHLF 842

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.