DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir40a and GRIK2

DIOPT Version :9

Sequence 1:NP_610140.4 Gene:Ir40a / 35449 FlyBaseID:FBgn0259683 Length:732 Species:Drosophila melanogaster
Sequence 2:NP_068775.1 Gene:GRIK2 / 2898 HGNCID:4580 Length:908 Species:Homo sapiens


Alignment Length:758 Identity:142/758 - (18%)
Similarity:263/758 - (34%) Gaps:215/758 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ALGLLPYLLGLLNSTRLTFIGNDESDTAIALTQIVRGLQQSSLAILALPSLALSDGVCQKERNVY 70
            ||.:.||....:|.|....:..:.       ||:...:::.|:..|..|         .|..:..
Human   263 ALDVEPYRYSGVNMTGFRILNTEN-------TQVSSIIEKWSMERLQAP---------PKPDSGL 311

  Fly    71 LDDFLQRLHRSNYKSVVFSQTELFFQHIEENLQGANECISLILDE-PNQLLNSLH-DRHLGHRLS 133
            ||.|:.......|.:|          |:          :|:.:.: |...::||. :||...|  
Human   312 LDGFMTTDAALMYDAV----------HV----------VSVAVQQFPQMTVSSLQCNRHKPWR-- 354

  Fly   134 LFIFYWGARWPPSSRVIRFREPLRVVVVTRPRKKAFRIYYNQARPC-SDSQLQLVNWYDGDNLGL 197
                 :|.|:            :.::..........||.:|:.... :|..|.:::..:.   ||
Human   355 -----FGTRF------------MSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEE---GL 399

  Fly   198 QRIPLLPTA--LSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTG- 259
            ::|.....|  |::..:.||:    |.                      |..||:..|.:.||. 
Human   400 EKIGTWDPASGLNMTESQKGK----PA----------------------NITDSLSNRSLIVTTI 438

  Fly   260 ----------------GRDH------RLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGK-----D 297
                            |.|.      .||..||..:.|.::.          ...||||     |
Human   439 LEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI----------RLVEDGKYGAQDD 493

  Fly   298 SNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEAL-AIM 359
            :|..:.|.:..|...:||..:..:.:::.|.|.|:||  |.||..|..:  ..|...|..: :.:
Human   494 ANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILY--RKPNGTNPGVFSFL 556

  Fly   360 RPFKQDIWPHLILTIIFSGPIFYGIIAL-PYIW-RRRWANSDVEHLGELYIHMTYLKEITPRLLK 422
            .|...|||.:::|..:....:.:.|... ||.| .....|.|.:.:...:               
Human   557 NPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNF--------------- 606

  Fly   423 LKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQL 487
                |:|::           .||.:...::|....:......:.:..::|. .|.::...|:|.|
Human   607 ----TLLNS-----------FWFGVGALMQQGSELMPKALSTRIVGGIWWF-FTLIIISSYTANL 655

  Fly   488 TSQFARPAREPPINTLQ------RLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALM--- 543
            .:.......|.||::..      :::...:.||..:...|:|.        ...:.:::|.|   
Human   656 AAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSK--------ISTYDKMWAFMSSR 712

  Fly   544 RQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVA 608
            ||.|:       :.|.|.||:.:..  .|.|.|....|:.| |.|...|..|:...:.::...|.
Human   713 RQSVL-------VKSNEEGIQRVLT--SDYAFLMESTTIEF-VTQRNCNLTQIGGLIDSKGYGVG 767

  Fly   609 VQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDS 673
            ..:|.|:...:...::||.|.|.|..|....:..           .|..:.::.||         
Human   768 TPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRG-----------NGCPEEESKEA--------- 812

  Fly   674 TVISPLNLRMLQGAFIALGVGSLAAGVILLLEIVFIKLDQARL 716
               |.|.::.:.|.||.|..|.:.:..:.:.|.::.....|:|
Human   813 ---SALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQL 852

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir40aNP_610140.4 PBP2_LTTR_substrate 216..338 CDD:330233 30/151 (20%)
Periplasmic_Binding_Protein_Type_2 297..>391 CDD:328725 25/97 (26%)
Periplasmic_Binding_Protein_Type_2 <496..637 CDD:328725 34/149 (23%)
GRIK2NP_068775.1 PBP1_iGluR_Kainate 37..414 CDD:380605 37/208 (18%)
Periplasmic_Binding_Protein_Type_2 430..800 CDD:419667 86/430 (20%)
Glutamate binding. /evidence=ECO:0000250|UniProtKB:P42260 516..518 0/1 (0%)