Protein Alignment Ir40a and GRID2

DIOPT Version :9

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_011530195.2
• Gene: GRID2 / 2895
• HGNCID: 4576
• Length: 1035
• Species: Homo sapiens
• Alignment Length: 931
• Identity: 158/931 - (16%)
• Similarity: 286/931 - (30%)
• Gaps: 344/931 - (36%)

  Fly    17 LNSTRLTFIGNDESDTAIALTQIVRGLQQSSLAILALPS----------LALSD----------- 60
            |..||.|   |..:..|.||.|  :..:..:..||||.|          .:|:|
Human    74 LRETRGT---NTTASPATALPQ--KTCELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQR 133

  Fly    61 ----------GVCQKERN----------VYLDDFLQRLHRSNY---KSVVFSQTELFFQHIEENL 102
                      |:.:..||          |||.|.:.|: .:.|   |.::|..:|...:.|:|.|
Human   134 STAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRV-VTEYAWQKFIIFYDSEYDIRGIQEFL 197

  Fly   103 -----QGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPPSSRVIRFREPLR--VVV 160
                 ||.:..:..:.:..|:::.:|.|......|:                 |:|:.||  ::|
Human   198 DKVSQQGMDVALQKVENNINKMITTLFDTMRIEELN-----------------RYRDTLRRAILV 245

  Fly   161 VTRPRKKAF---------------RIYYNQARPCSDSQLQLVNWYDGDNL---GLQRIPLLPTAL 207
            :.....|:|               .|..|:.          :|..|...|   .:.|:.::....
Human   246 MNPATAKSFITEVVETNLVAFDCHWIIINEE----------INDVDVQELVRRSIGRLTIIRQTF 300

  Fly   208 SVYANFKGRTFR----------------------------------VPVFH-------------- 224
            .|..|...|.||                                  ...||
Human   301 PVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASL 365

  Fly   225 ------SPPW------------------------------------------------------- 228
                  |.||
Human   366 SCIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKNER 430

  Fly   229 ---------FW--------VTYCNNSFEEDEEFNSLDSIEKRKVRVTG-----------GRDHR- 264
                     .|        ||..|.|..:.:..|::..:..|.|.|..           |:..:
Human   431 IRPQGSTGKIWPQLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKY 495

  Fly   265 ------LLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGL 323
                  :|..||.::.|.::...||....||.: |||     ::.|.:|.|...:||..:..:.:
Human   496 QGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQ-EDG-----TWNGLVGELVFKRADIGISALTI 554

  Fly   324 SWERRKAIEFSFFTLADSGAFATHAPRRLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGIIALP 388
            :.:|...::|:...:..|.........:..:..|.:.||...:|..:..|::..|.:.|.:
Human   555 TPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLL---- 615

  Fly   389 YIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQ 453
                 .|.|                          .||  |....|........:||....|::|
Human   616 -----NWLN--------------------------PPR--LQMGSMTSTTLYNSMWFVYGSFVQQ 647

  Fly   454 SCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQA------AMIH 512
            .....:.....:.:...:|:.|..|::. |:|.|.:.......|..|.:||.|..      ..:.
Human   648 GGEVPYTTLATRMMMGAWWLFALIVISS-YTANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVL 711

  Fly   513 DGYRLYVEKESSSLEMLENGTELFRQLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGE----DK 573
            |. .:|.......|...|..: ::.|::.::.:.  |..:...::| :|||:.:..|..    |.
Human   712 DS-AVYEHVRMKGLNPFERDS-MYSQMWRMINRS--NGSENNVLES-QAGIQKVKYGNYAFVWDA 771

  Fly   574 AVLGGRETLFFNVQQYGSNN------FQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGIL 632
            |||           :|.:.|      :.:...:..|...:|:|.|.|:....:..:::|.::|.:
Human   772 AVL-----------EYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDM 825

  Fly   633 DKMTAAEYAKQYQEVEATRIYKGSVQAKNSEA--YSRTESYDSTVISPLNLRMLQGAFIALGVGS 695
            |                  |.|.....||.:.  ||..::....  ..|:::...|.|..|..|.
Human   826 D------------------ILKHKWWPKNGQCDLYSSVDTKQKG--GALDIKSFAGVFCILAAGI 870

  Fly   696 LAAGVILLLEIVFIKLDQARL 716
            :.:..|.:||..:.|...:|:
Human   871 VLSCFIAMLETWWNKRKGSRV 891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	36/265 (14%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	15/93 (16%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	30/156 (19%)
GRID2	XP_011530195.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156071
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840