DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir40a and GRID1

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	734	Identity:	141/734 - (19%)
Similarity:	245/734 - (33%)	Gaps:	188/734 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FIGNDESDTAIALTQIVRGLQQSSLAILALPSL-----------ALSDGVCQKERNVYLDDFLQR 77
            |:..:.||..| |..:...|.:.::.....||.           .:|..:|..:     :.:||.
Human   257 FVNEEISDPEI-LDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQ-----EGYLQM 315

  Fly    78 LHRSN---YKSVVFSQTELFFQHIEE---NLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFI 136
            |..||   |.||:. ....|.:.:|:   :...:..||.......|...:.|.....||...|
Human   316 LQISNLYLYDSVLM-LANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGL-- 377

  Fly   137 FYWGARWPPSSRVIRFREP-----LRVVVVTRPRKKAFRIYYNQARPCSDSQLQLVNW--YDGDN 194
                      :.|:.|||.     ::..::.....:.|          .....:|..|  ..|.|
Human   378 ----------TGVMEFREDSSNPYVQFEILGTTYSETF----------GKDMRKLATWDSEKGLN 422

  Fly   195 LGLQRIPLLPTALSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTG 259
            ..||..|:       .:..:|.|.:|......|  :|....|...:.:.:... ||:
Human   423 GSLQERPM-------GSRLQGLTLKVVTVLEEP--FVMVAENILGQPKRYKGF-SID-------- 469

  Fly   260 GRDHRLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGKDS----NDSFTGGIGLLQSGQADFFLGD 320
                 :|..|:|.:.|:::..:||          ||:..    |.|:.|.||.|.|.:||..:..
Human   470 -----VLDALAKALGFKYEIYQAP----------DGRYGHQLHNTSWNGMIGELISKRADLAISA 519

  Fly   321 VGLSWERRKAIEFSFFTLADSGAFATHAPRRLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGII 385
            :.::.||...::||...:..|.......|.......::..||...:|..:...|...|.:.:.:.
Human   520 ITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLN 584

  Fly   386 ALPYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLF 450
            .:..:..:..|                           :||...||      .....||.....|
Human   585 RIQAVRAQSAA---------------------------QPRPSASA------TLHSAIWIVYGAF 616

  Fly   451 LKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRL--QAAM--- 510
            ::|......|....:.:...:|: .|.::...|:|.|.:.......:.||.|.|.|  |..|
Human   617 VQQGGESSVNSMAMRIVMGSWWL-FTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYG 680

  Fly   511 -IHDG--YRLYVEKESSSLEMLENGTELFRQLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGE- 571
             :.|.  |..:..|.::.||......||:|.:..       |......:.|...||:...:|..
Human   681 TVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISK-------NGGADNCVSSPSEGIRKAKKGNYA 738

  Fly   572 ---DKAVLGGRETLFFNVQQYGS-----------NNFQLSQKLYTRYSAVAVQIGCPFLGSLNNV 622
               |.||:           :|.:           .| .:|.|.|    .:|:|.|.|:....:..
Human   739 FLWDVAVV-----------EYAALTDDDCSVTVIGN-SISSKGY----GIALQHGSPYRDLFSQR 787

  Fly   623 LMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGA 687
            :::|.::|.||.:      ||.......|....|..:..::..|            |.|....|.
Human   788 ILELQDTGDLDVL------KQKWWPHMGRCDLTSHASAQADGKS------------LKLHSFAGV 834

  Fly   688 FIALGVGSLAAGVILLLEI 706
            |..|.:|.|.|.::..||:
Human   835 FCILAIGLLLACLVAALEL 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	28/125 (22%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	20/97 (21%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	36/163 (22%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		39/214 (18%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	35/194 (18%)
		ANF_receptor	41..400	CDD:279440	31/161 (19%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	89/458 (19%)
		Lig_chan	564..841	CDD:278489	64/351 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155863
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840