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Protein Alignment Ir40a and GRIA3

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_000819.4	Gene:	GRIA3 / 2892	HGNCID:	4573	Length:	894	Species:	Homo sapiens

Alignment Length:	594	Identity:	117/594 - (19%)
Similarity:	213/594 - (35%)	Gaps:	149/594 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 VTRPRKKAFRIYYNQARPCSDSQLQLVNWYDGDNLGLQRIPLLPTALSVYANFKGRTFRV-PVFH 224
            |:..||..:...|.:..|.||.|:      ..|:                |:.:.||..| .:..
Human   390 VSGSRKAGYWNEYERFVPFSDQQI------SNDS----------------ASSENRTIVVTTILE 432

  Fly   225 SPPWFWVTYCNN--SFEEDEEFNSLDSIEKRKVRVTGGRDHRLLMLLSKHMNFRFKYIEAPGRTQ 287
            ||   :|.|..|  ..|.:|.:.              |....|...::||:..::| :...|..:
Human   433 SP---YVMYKKNHEQLEGNERYE--------------GYCVDLAYEIAKHVRIKYK-LSIVGDGK 479

  Fly   288 GSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPR 350
            ...|..:.|..|    |.:|.|..|:||..:..:.::..|.:.|:||  |.:|..|  .....|:
Human   480 YGARDPETKIWN----GMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGIS--IMIKKPQ 538

  Fly   351 RLNEAL-AIMRPFKQDIWPHLILTIIFSGPIFYGIIAL--------PYIWRRRWANSDVEHLGEL 406
            :....: :.:.|...:||    :.|:|:   :.|:..:        ||.|.....|.:
Human   539 KSKPGVFSFLDPLAYEIW----MCIVFA---YIGVSVVLFLVSRFSPYEWHLEDNNEE------- 589

  Fly   407 YIHMTYLKEITPRLLKLKPRTVLSAHQMPHQ--LFQKCIWFTLRLFLKQSCNELHNGYRAKFLTI 469
                              ||...|....|::  :|.. :||:|..|::|.|:........:.:..
Human   590 ------------------PRDPQSPPDPPNEFGIFNS-LWFSLGAFMQQGCDISPRSLSGRIVGG 635

  Fly   470 VYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGT- 533
            |:|. .|.::...|:|.|.:.........||.:.:.|            .::...:...|::|:
Human   636 VWWF-FTLIIISSYTANLAAFLTVERMVSPIESAEDL------------AKQTEIAYGTLDSGST 687

  Fly   534 -ELFRQ----LYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNN 593
             |.||:    :|..|...:.:.....|..:...|:..:.:.....|.|.......:..|:...:.
Human   688 KEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDT 752

  Fly   594 FQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQ 658
            .::...|.::...||...|.....::|..:::|.|.|:|||:
Human   753 MKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKL----------------------- 794

  Fly   659 AKNSEAYSRTE-------SYDSTVISPLNLRMLQGAFIALGVGSLA-AGVILLLEIVFIKLDQAR 715
             ||...|.:.|       |.|.|  |.|:|..:.|.|..| ||.|. |.::.|:|..:....:::
Human   795 -KNKWWYDKGECGSGGGDSKDKT--SALSLSNVAGVFYIL-VGGLGLAMMVALIEFCYKSRAESK 855

  Fly   716 LWMLCSRLQ 724
            ...|....|
Human   856 RMKLTKNTQ 864

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.