DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir40a and GRIA1

DIOPT Version :9

Sequence 1:NP_610140.4 Gene:Ir40a / 35449 FlyBaseID:FBgn0259683 Length:732 Species:Drosophila melanogaster
Sequence 2:NP_001244950.1 Gene:GRIA1 / 2890 HGNCID:4571 Length:916 Species:Homo sapiens


Alignment Length:540 Identity:101/540 - (18%)
Similarity:199/540 - (36%) Gaps:111/540 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   189 WYDGDNLGLQRIPLLPTALSVYA-----NFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLD 248
            |.:.|.       .:|.|....|     :.:.||:.|......|:..:....|.||.::.:.   
Human   392 WNEDDK-------FVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYE--- 446

  Fly   249 SIEKRKVRVTGGRDHRLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQ 313
                       |....|...::||:.:.:: :|.....:...|..|.|    ::.|.:|.|..|:
Human   447 -----------GYCVELAAEIAKHVGYSYR-LEIVSDGKYGARDPDTK----AWNGMVGELVYGR 495

  Fly   314 ADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEAL-AIMRPFKQDIWPHLILTII 375
            ||..:..:.::..|.:.|:||  |.:|..|  .....|::....: :.:.|...:||    :.|:
Human   496 ADVAVAPLTITLVREEVIDFSKPFMSLGIS--IMIKKPQKSKPGVFSFLDPLAYEIW----MCIV 554

  Fly   376 FSGPIFYGIIALPYIWRR----RWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPH 436
            |:   :.|:..:.::..|    .|.:.:.|                      :.|...::.|...
Human   555 FA---YIGVSVVLFLVSRFSPYEWHSEEFE----------------------EGRDQTTSDQSNE 594

  Fly   437 QLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPIN 501
            ......:||:|..|::|.|:........:.:..|:|. .|.::...|:|.|.:.........||.
Human   595 FGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWF-FTLIIISSYTANLAAFLTVERMVSPIE 658

  Fly   502 TLQRLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALMRQQVINDPQGFFIDSVEAGIKLI 566
            :.:.| |......|.. :|..|:......:...:|.:::..|:..   :|..|...:.|..|::.
Human   659 SAEDL-AKQTEIAYGT-LEAGSTKEFFRRSKIAVFEKMWTYMKSA---EPSVFVRTTEEGMIRVR 718

  Fly   567 AEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGI 631
            ...|:...:|......:.. |:...:..::...|.::...:|...|......:|..:::|.|.|:
Human   719 KSKGKYAYLLESTMNEYIE-QRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGL 782

  Fly   632 LDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTE-------SYDSTVISPLNLRMLQGAFI 689
            |||:                        ||...|.:.|       |.|.|  |.|:|..:.|.|.
Human   783 LDKL------------------------KNKWWYDKGECGSGGGDSKDKT--SALSLSNVAGVFY 821

  Fly   690 ALGVGSLA-AGVILLLEIVF 708
            .| :|.|. |.::.|:|..:
Human   822 IL-IGGLGLAMLVALIEFCY 840

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir40aNP_610140.4 PBP2_LTTR_substrate 216..338 CDD:330233 26/123 (21%)
Periplasmic_Binding_Protein_Type_2 297..>391 CDD:328725 20/96 (21%)
Periplasmic_Binding_Protein_Type_2 <496..637 CDD:328725 26/140 (19%)
GRIA1NP_001244950.1 PBP1_iGluR_AMPA_GluR1 36..399 CDD:107385 2/13 (15%)
ANF_receptor 47..382 CDD:279440
PBP2_iGluR_AMPA_GluR1 416..797 CDD:270447 81/461 (18%)
Lig_chan 548..827 CDD:278489 62/341 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156052
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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