DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir40a and Grin2c

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_036707.3	Gene:	Grin2c / 24411	RGDID:	2739	Length:	1250	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	96/487 - (19%)
Similarity:	171/487 - (35%)	Gaps:	144/487 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 LLMLLSKHMNFRFK-YIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERR 328
            :|..|:|.:.|.:. |:...|:        .||.....:.|.||.:...:||..:|.:.::.||.
  Rat   474 ILKKLAKVVKFSYDLYLVTNGK--------HGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERS 530

  Fly   329 KAIEFSF------FTLADSGAFATHAPRRLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGIIAL 387
            :.|:||.      .::..|.:..|.:|.      |.:.|:...:|..:.:..:       .::|:
  Rat   531 EIIDFSVPFVETGISVMVSRSNGTVSPS------AFLEPYSPAVWVMMFVMCL-------TVVAI 582

  Fly   388 PYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLK 452
            ...            :.|.:..::|.:.:|.   ..||..       |.....|.:|....|...
  Rat   583 TVF------------MFEYFSPVSYNQNLTK---GKKPGG-------PSFTIGKSVWLLWALVFN 625

  Fly   453 QSCN-ELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMI---HD 513
            .|.. |...|..:|.:.:|:...|...||. |:|.|.   |...:|..|:|:..|.....   .|
  Rat   626 NSVPIENPRGTTSKIMVLVWAFFAVIFLAS-YTANLA---AFMIQEQYIDTVSGLSDKKFQRPQD 686

  Fly   514 GYRLY----VEKESSSLEMLENGTELFRQLYALM---RQQVINDP---------QGFFIDSV--- 559
            .|..:    |...|:...:..|    :|.::..|   .|:.:.|.         ..|..|:.
  Rat   687 QYPPFRFGTVPNGSTERNIRSN----YRDMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLN 747

  Fly   560 -----EAGIKLIAEG-GEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGS 618
                 :.|.||:..| |:..|..|           ||                :|:|....:..:
  Rat   748 YMAGKDEGCKLVTIGSGKVFATTG-----------YG----------------IAMQKDSHWKRA 785

  Fly   619 LNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRM 683
            ::..|:||...|            :.|::|...: .|..|.:.:|..|          |.|::..
  Rat   786 IDLALLQLLGDG------------ETQKLETVWL-SGICQNEKNEVMS----------SKLDIDN 827

  Fly   684 LQGAFIALGVGSLAAGVILLL----EIVFIKL 711
            :.|.|..|.|   |.|:.||:    .:|:.||
  Rat   828 MAGVFYMLLV---AMGLALLVFAWEHLVYWKL 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	19/79 (24%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	18/99 (18%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	30/168 (18%)
Grin2c	NP_036707.3	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	80/429 (19%)
		NMDAR2_C	850..>925	CDD:402274	3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350095
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930