Protein Alignment Ir40a and Grin3a

DIOPT Version :9

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_612555.1
• Gene: Grin3a / 191573
• RGDID: 621704
• Length: 1135
• Species: Rattus norvegicus
• Alignment Length: 505
• Identity: 100/505 - (19%)
• Similarity: 178/505 - (35%)
• Gaps: 157/505 - (31%)

  Fly   235 NNSFEEDEEFNSL----DSIEKRKVRVTGGRDHRLLMLLSKHMNFRFK-YIEAPGRTQGSMRSED 294
            |:|...|..|:||    |::..:..:...|....||..|::.|||.|. ||...|:.
  Rat   549 NDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKY-------- 605

  Fly   295 GKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FF------------TLADSGAFA 345
            |...|..:||.:|.|.||.|:..:....::..|.:.|:|:  ||            |.|..|||
  Rat   606 GAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAF- 669

  Fly   346 THAPRRLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGIIALPYIWRRRWANSDVEHLGELYIHM 410
                         |.|....:|..:.:.:..:. ||..:    |.|:..:.
  Rat   670 -------------MWPLHWTMWLGIFVALHITA-IFLTL----YEWKSPFG-------------- 702

  Fly   411 TYLKEITPR-LLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIA 474
                 :||: ..:.|..:..||..:.:.|          ||.:.:..:....:..:||..::.|.
  Rat   703 -----MTPKGRNRNKVFSFSSALNVCYAL----------LFGRTAAIKPPKCWTGRFLMNLWAIF 752

  Fly   475 ATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIH---DGYRLYVEKESSSLEMLENGTELF 536
            ..:.|: .|:|.|.   |....|.....|..:....:|   .|:|....:|||:.:.:.   :.|
  Rat   753 CMFCLS-TYTANLA---AVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVR---QSF 810

  Fly   537 RQLYALMR-----------QQVINDPQ---GFFID--------SVEAGIKLIAEGGEDKAVLGGR 579
            .:::..||           |.:.|||:   .|.:|        |::|..||:..|..
  Rat   811 PEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKP-------- 867

  Fly   580 ETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQY 644
                |.::.||                :.:....|...:::.::.|....|.:|.:    :.|.|
  Rat   868 ----FAIEGYG----------------IGLPPNSPLTSNISELISQYKSHGFMDVL----HDKWY 908

  Fly   645 QEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVG 694
            :.|..         .|.|.|.:.|        ..:.::...|.|:.|.:|
  Rat   909 KVVPC---------GKRSFAVTET--------LQMGIKHFSGLFVLLCIG 941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	32/121 (26%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	24/107 (22%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	29/165 (18%)
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..117
		ANF_receptor	127..469	CDD:279440
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	90/453 (20%)
		Lig_chan	676..942	CDD:278489	61/356 (17%)
		PPP2CB binding site	951..987
		GIT1-binding. /evidence=ECO:0000269|PubMed:24297929	1082..1115

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350009
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930