Protein Alignment Ir40a and Grin3b

DIOPT Version :9

• Sequence 1: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_579842.2
• Gene: Grin3b / 170796
• RGDID: 621705
• Length: 1002
• Species: Rattus norvegicus
• Alignment Length: 766
• Identity: 148/766 - (19%)
• Similarity: 258/766 - (33%)
• Gaps: 239/766 - (31%)

  Fly    52 ALPSLALSDGVCQKERNVYLDDFLQRLHRSNYKSVVFSQTELFFQ--------HIEENL------ 102
            |||:..|..||..          |....:.:.::||....||..|        |.|..|
  Rat   268 ALPTTGLPPGVLA----------LGETEQHSLEAVVHDMVELVAQALSSMALVHPERALLPAVVN 322

  Fly   103 -----QGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPPSSRVIRFREPLRVVVVT 162
                 .|.:|.....|           .|.||:  :.|....||.|...|..:..
  Rat   323 CDDLKTGGSEATGRTL-----------ARFLGN--TSFQGRTGAVWVTGSSQVHV---------- 364

  Fly   163 RPRKKAFRIYYNQARPCSDSQLQLV-NWYDGDNLGLQRIPLLPTALSVYANFKGRT-----FRVP 221
               .:.|:::..:..|........| :|.||      ::...|.|.::.......|     .||.
  Rat   365 ---SRHFKVWSLRRDPLGAPAWATVGSWQDG------QLDFQPGAAALRVPSPSGTQARPKLRVV 420

  Fly   222 VFHSPPWFWV------------TYC-----NNSFEEDEEFNSL--DSIEKRKVRVTGGRDHRLLM 267
            .....|:.:.            ..|     |:|...|..|.:|  .|:.:...|...|....||.
  Rat   421 TLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRRCCYGYCIDLLE 485

  Fly   268 LLSKHMNFRFK-YIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAI 331
            .|::.:.|.|: ||...|: .|::|  ||:     :||.:|.|.:|:|...:....::..|.:.:
  Rat   486 RLAEDLAFDFELYIVGDGK-YGALR--DGR-----WTGLVGDLLAGRAHMAVTSFSINSARSQVV 542

  Fly   332 EFSFFTLADSGAFATHAPRRLNEALAIM-------RPFKQDIWP-HLILTI-IFSGPIFYGIIAL 387
            :|:      |..|:|        :|.||       .|....:|| |..:.: :|:......:...
  Rat   543 DFT------SPFFST--------SLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFLT 593

  Fly   388 PYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLK 452
            .|.||..:.                   :|||   .:.|..:.::.....|   |...   ||.:
  Rat   594 LYEWRSPYG-------------------LTPR---GRNRGTVFSYSSALNL---CYAI---LFGR 630

  Fly   453 QSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHD---- 513
            ...::.......:||..::.|....||:. |:|.|.:.....      .|.:.|..  |||
  Rat   631 TVSSKTPKCPTGRFLMNLWAIFCLLVLSS-YTANLAAVMVGD------KTFEELSG--IHDPKLH 686

  Fly   514 ----GYRLYVEKESSSLEMLENGTELFRQLYALMRQ-----------QVINDP---QGFFID--- 557
                |:|.....|||:...::..   |.:::|.||:           .:.:||   ..|.:|
  Rat   687 HPSQGFRFGTVWESSAEAYIKAS---FPEMHAHMRRHSAPTTPHGVAMLTSDPPKLNAFIMDKSL 748

  Fly   558 -----SVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLG 617
                 |::|..||:..|..            |.::.||                :.:....|...
  Rat   749 LDYEVSIDADCKLLTVGKP------------FAIEGYG----------------IGLPQNSPLTS 785

  Fly   618 SLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLR 682
            :|:..:.:...||.:|.:    :.|.|:.|..           ....::.||:..      :.:.
  Rat   786 NLSEFISRYKSSGFIDLL----HDKWYKMVPC-----------GKRVFAVTETLQ------MGVY 829

  Fly   683 MLQGAFIALGVGSLAAGVILLLEIVFIKLDQARLWMLCSRLQ-WIRYDRKV 732
            ...|.|:.|.:|..:|.:..|.|.||.:|...|: ...::|| |:...:|:
  Rat   830 HFSGLFVLLCLGLGSALLTSLGEHVFYRLVLPRI-RRGNKLQYWLHTSQKI 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	33/146 (23%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	20/102 (20%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	31/170 (18%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372	34/178 (19%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	94/487 (19%)
		Lig_chan	576..842	CDD:278489	59/354 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	882..910
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350093
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930