DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir40a and gria2a

DIOPT Version :9

Sequence 1:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_005170953.1	Gene:	gria2a / 170450	ZFINID:	ZDB-GENE-020125-3	Length:	893	Species:	Danio rerio

Alignment Length:	733	Identity:	143/733 - (19%)
Similarity:	272/733 - (37%)	Gaps:	193/733 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 QKERNVYLD-------DFLQRL-----HRSNYKSVVFSQTELFFQHIEENLQ-----GANECISL 111
            :.||.|.||       |.::::     |...|..::.:     |..::.:|.     |||.....
Zfish   197 KNERRVILDCEQDKVKDIMEQVITIGRHVKGYHYIIAN-----FGFVDGDLSKIQYGGANVSGFQ 256

  Fly   112 ILDEPNQLLNSLHDRHLGHRLSLFIFYWGA----RWPPSSRVIRFREPL---RVVVVTRPRKKAF 169
            |:|..:.|:.....|            |.|    .:|.:...||:...|   .|.|:|    :||
Zfish   257 IVDFDDPLVAKFDQR------------WEALEEKEYPGADSRIRYTSALTYDAVQVMT----EAF 305

  Fly   170 RIYYNQ--------------ARPCSDSQLQLVNWYDGDNL--GLQRIPLLPTALSVYANFKGR-- 216
            |..:.|              |.|.       |.|..|..:  .|:::.:.....::..:..||
Zfish   306 RFLHKQRIDISRRGNNGDCLANPA-------VPWAQGVEIERALKQVRVDGLTGNIQFDQYGRRV 363

  Fly   217 TFRVPVF---HSPP---WFWVTYCNNSFEEDEEF-NSLDSIEKRKVRVTGGRDHRLLML------ 268
            .:.|.|.   :|.|   .:|......:..:.:.| |....:|.:.|.||...:...:||
Zfish   364 NYTVNVMELKNSGPVKIGYWNEMDKMAVTKSDLFPNDTMGMENKTVIVTTILEAPYVMLKKNAEL 428

  Fly   269 -----------------LSKHMNFRFKY-IEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQAD 315
                             ::||..|:::. |.|.|: .|:..:|     ...:.|.:|.|..|:||
Zfish   429 FTDNERYEGYCVDLAAEIAKHCGFKYQLRIVADGK-YGARDAE-----TKIWNGMVGELVYGKAD 487

  Fly   316 FFLGDVGLSWERRKAIEFS--FFTLADSGAFATHAPRRLNEAL-AIMRPFKQDIWPHLILTIIFS 377
            ..:..:.::..|.:.|:||  |.:|..|  .....|::....: :.:.|...:||    :.|:|:
Zfish   488 IAVAPLTITLVREEVIDFSKPFMSLGIS--IMIKKPQKSKPGVFSFLDPLAYEIW----MCIVFA 546

  Fly   378 GPIFYGIIALPYIWRR----RWANSDVE--HLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPH 436
               :.|:..:.::..|    .|...:.|  .||.                        |......
Zfish   547 ---YIGVSVVLFLVSRFSPYEWHTEEFEDGQLGP------------------------SESTNEF 584

  Fly   437 QLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPIN 501
            .:|.. :||:|..|::|.|:........:.:..|:|. .|.::...|:|.|.:.........||.
Zfish   585 GIFNS-LWFSLGAFMQQGCDISPRSLSGRIVGGVWWF-FTLIIISSYTANLAAFLTVERMVSPIE 647

  Fly   502 TLQRLQAAMIHDGYRLYVEKESSSLEMLENGT--ELFRQ----LYALMRQQVIN-DPQGFFIDSV 559
            :.:.|            .::...:...|:.|:  |.||:    |:..|.|.:.: :|..|..::|
Zfish   648 SAEDL------------AKQTEIAYGTLDAGSTKEFFRRSKIALFDKMWQYMKSAEPSVFVKNTV 700

  Fly   560 EAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLM 624
            |..:::....|:...:|......:.. |:...:..::...|.::...:|...|.....::|..::
Zfish   701 EGVLRVRKSKGKYAYLLESTMNEYIE-QRKPCDTMKVGGNLDSKGYGIATPKGSALRNAVNLAVL 764

  Fly   625 QLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFI 689
            :|.|.|:|||:.    .|.:.:       ||...:...|:..:|        |.|:|..:.|.|.
Zfish   765 KLNEQGLLDKLK----NKWWYD-------KGECGSGGGESKEKT--------SALSLSNVAGVFY 810

  Fly   690 ALGVGSLAAGVILLLEIV 707
            .| ||.|  |:.:|:.:|
Zfish   811 IL-VGGL--GLAMLVALV 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	33/156 (21%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	20/96 (21%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	28/147 (19%)
gria2a	XP_005170953.1	Periplasmic_Binding_Protein_Type_1	23..391	CDD:299141	43/221 (19%)
		ANF_receptor	51..373	CDD:279440	40/203 (20%)
		PBP2_iGluR_AMPA	406..783	CDD:270433	81/441 (18%)
		Lig_chan	538..816	CDD:278489	65/343 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591641
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840